Patents by Inventor Tim R. Blake

Tim R. Blake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immolative cell-penetrating complexes for nucleic acid delivery to the lung
    Patent number: 11931416
    Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim R. Blake, Paul Wender, Robert M. Waymouth, Ronald Levy, Ole Audun Werner Haabeth, Rebecca McClellan, Adrienne Sallets
  • IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY TO THE LUNG
    Publication number: 20220143199
    Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
    Type: Application
    Filed: January 31, 2020
    Publication date: May 12, 2022
    Inventors: Tim R. BLAKE, Paul WENDER, Robert M. WAYMOUTH, Ronald LEVY, Ole Audun Werner HAABETH, Rebecca MCCLELLAN, Adrienne SALLETS
  • HYBRID IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY
    Publication number: 20220088163
    Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.
    Type: Application
    Filed: November 11, 2019
    Publication date: March 24, 2022
    Inventors: Tim R. BLAKE, Robert M. WAYMOUTH, Paul WENDER, Ronald LEVY, Ole Audun Werner HAABETH, Matthew FRANK, Adrienne SALLETS
  • IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY
    Publication number: 20180028688
    Abstract: There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.
    Type: Application
    Filed: July 27, 2017
    Publication date: February 1, 2018
    Inventors: Robert M. Waymouth, Paul Wender, Jessica R. Vargas, Tim R. Blake, Colin McKinlay, Ronald Levy, Ole Audun Werner Haabeth, Nancy Benner, Katherine Near