Patents by Inventor Tim Townes

Tim Townes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR/CAS9 COMPLEX FOR GENOMIC EDITING
    Publication number: 20240117380
    Abstract: Provided herein are CRISPR/Cas9 complexes and method of using same.
    Type: Application
    Filed: April 4, 2023
    Publication date: April 11, 2024
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Tim Townes, Lei Ding, Chia-Wei Chang
  • CRISPR/Cas9 complex for genomic editing
    Patent number: 11643668
    Abstract: Provided herein are CRISPR/Cas9 complexes and method of using same.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: May 9, 2023
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Tim Townes, Lei Ding, Chia-Wei Chang
  • CRISPR/Cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
    Patent number: 11555207
    Abstract: Provided herein are CRIS-PR/Cas9 complexes and methods of using same.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: January 17, 2023
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Tim Townes, Lei Ding, Chia-Wei Chang
  • COMPOSITIONS AND METHODS FOR UPREGULATION OF HUMAN FETAL HEMOGLOBIN
    Publication number: 20220257629
    Abstract: Provided herein are compositions and methods for increasing fetal hemoglobin in a subject in need thereof. Also provided are compositions and methods for treating a hemoglobin disorder in a subject.
    Type: Application
    Filed: July 30, 2020
    Publication date: August 18, 2022
    Inventors: Tim Townes, Dewang Zhou
  • CRISPR/CAS9 COMPLEX FOR GENOMIC EDITING
    Publication number: 20190144888
    Abstract: Provided herein are CRISPR/Cas9 complexes and method of using same.
    Type: Application
    Filed: June 17, 2016
    Publication date: May 16, 2019
    Inventors: Tim Townes, Lei Ding, Chia-Wei Chang
  • CRISPR/CAS9 COMPLEX FOR INTRODUCING A FUNCTIONAL POLYPEPTIDE INTO CELLS OF BLOOD CELL LINEAGE
    Publication number: 20190032089
    Abstract: Provided herein are CRIS-PR/Cas9 complexes and methods of using same.
    Type: Application
    Filed: June 17, 2016
    Publication date: January 31, 2019
    Inventors: Tim Townes, Lei Ding, Chia-Wei Chang
  • Polycistronic Vector for Human Induced Pluripotent Stem Cell Production
    Publication number: 20160076000
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Application
    Filed: September 29, 2015
    Publication date: March 17, 2016
    Inventors: Tim Townes, Kevin M. Pawlik
  • Polycistronic vector for human induced pluripotent stem cell production
    Patent number: 9175311
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: November 3, 2015
    Assignee: The UAB Research Foundation
    Inventors: Tim Townes, Kevin M. Pawlik
  • Polycistronic Vector for Human Induced Pluripotent Stem Cell Production
    Publication number: 20130017596
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Application
    Filed: May 25, 2012
    Publication date: January 17, 2013
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: TIM TOWNES, KEVIN M. PAWLIK
  • Polycistronic Vector For Human Induced Pluripotent Stem Cell Production
    Publication number: 20100150889
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 17, 2010
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Tim Townes, Kevin M. Pawlik
  • Xanthine oxidase inhibition as a strategy to alleviate oxidative impairment of vascular function
    Publication number: 20030158213
    Abstract: Disclosed is a method for alleviating the oxidative impairment of vascular function by inhibiting the activity of xanthine oxidase, or active forms thereof. Xanthine oxidase levels have been shown to be increased by a variety of conditions, including sickle cell disease. In the present disclosure, allopurinol is used to inhibit xanthine oxidase activity. As a result of the inhibition of xanthine oxidase, .NO levels in a subject can be maintained. In addition to sickle cell disease, allopurinol inhibition of xanthine oxidase may be used to treat other conditions, including, but not limited to, respiratory distress, kidney disease, liver disease, ischemia-reperfusion injury, organ transplant, sepsis, burns, viral infections and hemorrhagic shock.
    Type: Application
    Filed: November 18, 2002
    Publication date: August 21, 2003
    Inventors: Bruce A. Freeman, Margaret Tarpey, Tom Ryan, Tim Townes, Mutay Aslan