Abstract: Methods for operating a medical imaging device for positionally correct representation of non-anatomical structures during an imaging examination may include providing a first 3D image containing at least one anatomical structure, extracting at least one anatomical model from the at least one anatomical structure, providing 2D update images recorded at different times, extracting non-anatomical and anatomical structures from subsets of the update images, calculating a non-anatomical 3D image from at least two partial reconstructions based on the extracted non-anatomical structures, reconstructing an anatomical 3D image based on the extracted anatomical structures, registering the anatomical 3D image with the first 3D image by determining a coordinate transformation, and creating a navigation volume from the anatomical model and the non-anatomical 3D image using the coordinate transformation.