Abstract: Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.

Abstract: Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.

Abstract: Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.

Abstract: An image sensor comprising a substrate including a logic region and a pixel region, wherein the logic region is configured to form at least a portion of an active logic device therein, the pixel region is configured to form a pixel unit therein, the pixel unit including at least a photosensitive element, wherein an upper surface of the logic region is lower than an upper surface of the pixel region.

Abstract: Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.

Abstract: The present invention generally relates to libraries, kits, methods, applications and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other aspects related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas systems and components thereof. The present invention also relates to rules for making potent single guide RNAs (sgRNAs) for use in CRISPR-Cas systems. Provided are genomic libraries and genome wide libraries, kits, methods of knocking out in parallel every gene in the genome, methods of selecting individual cell knock outs that survive under a selective pressure, methods of identifying the genetic basis of one or more medical symptoms exhibited by a patient, and methods for designing a genome-scale sgRNA library.

Abstract: An animal-breeding mechanic enables the generation of an offspring virtual animal in an online game system by combining features of a male virtual animal and a female virtual animal. Relevant features may include a base color and optional pattern markings with a corresponding pattern color. Additional game aspects may include options for enhancing the likelihood of generating a successful offspring, decreasing the time for generating the offspring, and nurturing the offspring to maturity. Parameter representations for color features enable substituting color values for a specific virtual animal into source artwork to generate a variety of distinctive displays.

Abstract: An animal-breeding mechanic enables the generation of an offspring virtual animal in an online game system by combining features of a male virtual animal and a female virtual animal. Relevant features may include a base color and optional pattern markings with a corresponding pattern color. Additional game aspects may include options for enhancing the likelihood of generating a successful offspring, decreasing the time for generating the offspring, and nurturing the offspring to maturity. Parameter representations for color features enable substituting color values for a specific virtual animal into source artwork to generate a variety of distinctive displays.

Abstract: An animal-breeding mechanic enables the generation of an offspring virtual animal in an online game system by combining features of a male virtual animal and a female virtual animal. Multiple candidates for the offspring virtual animal may be generated, and a selection or identification can then be made from the multiple candidates. Relevant features may include a base color and optional pattern markings with a corresponding pattern color. Additional game aspects may include options for enhancing the likelihood of generating a successful offspring, decreasing the time for generating the offspring, and nurturing the offspring to maturity. Parameterized color values for a specific virtual animal may be substituted into source artwork to generate a variety of distinctive displays.

Abstract: In some aspects, compositions and methods useful for classifying tumor cells, tumor cell lines, or tumors according to predicted sensitivity to 3-bromopyruvate (3-BrPA) are provided. In some aspects, methods of identifying subjects with cancer who are candidates for treatment with 3-BrPA are provided. In some aspects, compositions useful for subjects with cancers that express increased levels of MCT1 are provided. In some aspects, methods of treating subjects with cancers that express increased levels of MCT1 are provided. In some aspects, methods of identifying anti-tumor agents the efficacy of which is at least in part dependent on transporter-mediated uptake are provided.

Abstract: The method and/or apparatus monitors and records the times when a user interacts with a network video player, e.g. a web video player, while watching an online video clip. Specifically, a data collection agent (DCA) is loaded to the player or to a web page that displays the video clip. The DCA collects detailed viewing information and periodically sends this information to a central server. The viewing information is processed by the central server to generate at least one of: a viewership attention span report, a viewership demographics report, and a viewership geographic report.

Abstract: An online game includes a mechanic for combining visual display parameters of virtual objects including virtual animals. In some embodiments features of a first virtual object and a second virtual object are combined to generate a third virtual object, where these features may include a base color and optional pattern markings with a corresponding pattern color. Additional game aspects may include generating multiple candidates for the third virtual object and selecting or identifying the third virtual object from the multiple candidates. Additional game aspects may also include options for enhancing the likelihood of successfully generating a third virtual object. Parameterized color values for a specific virtual object may be substituted into source artwork to generate a variety of distinctive displays.

Abstract: An online game includes a mechanic for combining visual display parameters of virtual objects including virtual animals. In some embodiments features of a first virtual object and a second virtual object are combined to generate a third virtual object, where these features may include a base color and optional pattern markings with a corresponding pattern color. Additional game aspects may include generating multiple candidates for the third virtual object and selecting or identifying the third virtual object from the multiple candidates. Additional game aspects may also include options for enhancing the likelihood of successfully generating a third virtual object. Parameterized color values for a specific virtual object may be substituted into source artwork to generate a variety of distinctive displays.

Abstract: An animal-breeding mechanic enables the generation of an offspring virtual animal in an online game system by combining features of a male virtual animal and a female virtual animal. Multiple candidates for the offspring virtual animal may be generated, and a selection or identification can then be made from the multiple candidates. Relevant features may include a base color and optional pattern markings with a corresponding pattern color. Additional game aspects may include options for enhancing the likelihood of generating a successful offspring, decreasing the time for generating the offspring, and nurturing the offspring to maturity. Parameterized color values for a specific virtual animal may be substituted into source artwork to generate a variety of distinctive displays.

Abstract: The method and/or apparatus monitors and records the times when a user interacts with a network video player, e.g. a web video player, while watching an online video clip. Specifically, a data collection agent (DCA) is loaded to the player or to a web page that displays the video clip. The DCA collects detailed viewing information and periodically sends this information to a central server. The viewing information is processed by the central server to generate at least one of: a viewership attention span report, a viewership demographics report, and a viewership geographic report.

Abstract: This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel everninomicin-related compounds based on everninomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A Micromonospora site-specific integrase gene is also provided, which can be incorporated in a vector for integration into any actinomycete, and, particularly into Monospora.

Abstract: A fiber optical circulator includes a first collimator and a second collimator sandwiching a circulator core therebetween. The first collimator and the second collimator respectively define Port 1 and Port 2 thereof, and the first collimator further defines Port 3 thereof. The circulator core includes a first crystal and a second crystal at two ends respectively confronting the first collimator and the second collimator aside. The circulator core further includes a first group of two half-wavelength waveplates and a first Faraday rotator, and second subassembly a second group of two half-wavelength waveplates and a second Faraday rotator. A third crystal is disposed between the first subassembly and the second subassembly wherein a backward light path from Port 2 to Port 3 passes the third crystal and is deflected by the third crystal toward the first collimator though total internal reflection.

Abstract: An antenna formed of a mounting base, an antenna terminal and a transmission box is described for use in an automobile. The antenna terminal is pivotally attached to the mounting base by a ball and socket joint. The mounting base has a bearing plate supported on a spring member and forced by the spring member to adjustably positively hold down the antenna terminal in position.

Abstract: An antenna formed of a mounting base, an antenna terminal and a transmission box is described for use in an automobile. The antenna terminal is pivotally attached to the mounting base by a ball and socket joint. The mounting base has a bearing plate supported on a spring member and forced by the spring member to adjustably positively hold down the antenna terminal in position.