Abstract: A method for isolating trace components selected from various groups and substances as set forth in the disclosure includes a) lysis of the cells and/or b) depletion of proteins by binding on mobile, magnetic silica gel beads and/or c) removal of peptides, amino acids, sugars, lipids, phospholipids and inorganic salts by binding on mobile, magnetic silica gel beads. The binding on the mobile, magnetic silica gel beads under b) and/or c) takes place non-selectively, selectively and/or reversibly, and the isolation of the trace components takes place timely offset after steps b) and/or c) with the aid of magnetic separation by binding on the surface of the mobile, magnetic silica gel beads, which differ from the mobile, magnetic silica gel beads under b) and/or c) in terms of different functional groups.