Patents by Inventor Timo Korpela
Timo Korpela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10961136Abstract: A method and device is provided for combining various forms of flotation techniques to achieve a very high degree of purification of waste water while energy consumption is maintained low.Type: GrantFiled: January 25, 2019Date of Patent: March 30, 2021Assignee: OY ELFLOT LTDInventors: Timo Korpela, Alexander Lashkul, Choong-Kyang Kang
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Publication number: 20190322549Abstract: A method and device is provided for combining various forms of flotation techniques to achieve a very high degree of purification of waste water while energy consumption is maintained low.Type: ApplicationFiled: January 25, 2019Publication date: October 24, 2019Applicant: OY ELFLOT LTDInventors: Timo KORPELA, Alexander LASHKUL, Choong-Kyang KANG
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Patent number: 10294130Abstract: The invention provides a device to purify waste water by a two-step procedure containing an electroflotation unit and an electrical disinfection unit integrated into the same overall construction. Characteristic to the construction is that the said two units have a common anode and two individual cathodes which can be in different potentials in respect to the common anode.Type: GrantFiled: October 19, 2016Date of Patent: May 21, 2019Assignee: OY Elflot LtdInventors: Timo Korpela, Choong-Kyang Kang, Alexander Lashkul
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Publication number: 20180354818Abstract: The invention provides a device to purify waste water by a two-step procedure containing an electroflotation unit and an electrical dis-infection unit integrated into the same overall construction. Characteristic to the construction is that the said two units have a common anode and two individual cathodes which can be in different potentials in respect to the common anode.Type: ApplicationFiled: October 19, 2016Publication date: December 13, 2018Inventors: Timo Korpela, Choong-Kyang Kang, Alexander Lashkul
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Publication number: 20160367515Abstract: The invention discloses a novel significantly improved carrier protein for pharmaceutical applications: metal ion-stabilized alfa-fetoprotein, AFP. The stabilized AFP serves as a novel universal drug delivery vehicle in formulating drugs to be targeted to cancer cells. Various transition metal ions form non-covalent adducts with AFP and stabilize it against physical and chemical factors in physiological fluids while not affecting its ability to target to AFP receptor-expressing cells.Type: ApplicationFiled: November 18, 2014Publication date: December 22, 2016Applicant: Oy Safemed Ltd.Inventors: Elena Dudich, Igor Vyacheslavovich Dudich, Lidia Nikolaevna Semenkova, Eduard Tatulov, Timo Korpela
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Patent number: 7592509Abstract: The invention relates to isolated DNA sequences encoding MF3 polypeptides that induce multiple resistance in plants toward a variety of viral and microbial infections and against pests and a method of obtaining transgenic plants expressing MF3 polypeptides. The invention also relates to a method of isolating and purifying an MF3 polypeptide from bacterial cells expressing the polypeptide and its use as a plant protectant with or without carrier agent.Type: GrantFiled: December 17, 2004Date of Patent: September 22, 2009Inventors: Vitaly Dzhavakhia, Alexei Filippov, Konstantin Skryabin, Tatiana Voinova, Daria Shumilina, Ksenia Kromina, Maria Kouznetsova, Olga Shulga, Mikhail Pridanniko, Natalia Battchikova, Timo Korpela
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Patent number: 7513983Abstract: Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.Type: GrantFiled: December 5, 2005Date of Patent: April 7, 2009Assignee: Labmaster Ltd.Inventors: Timo Ala-Kleme, Philip Canty, Jarkko Eskola, Timo Korpela, Sakari Kulmala, Piia Vainio
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Publication number: 20070192898Abstract: The object of the invention is a protein, termed MF3, or a functional derivative thereof with a novel structure that surprisingly can induce multiple resistance in plants toward a variety of viral and microbial infections and against pests. The invention also concerns an isolated DNA sequence encoding MF3 protein, as such, or as a part of any DNA sequence, or a fragment thereof, or DNA sequences which have degenerate codons with respect to the DNA sequence defined above. The invention also concerns a method of isolating and purifying the protein MF3 from bacterial cells expressing the said protein and its use as a plant protectant with or without carrier agent. Furthermore, the invention concerns a method of obtaining transgenic plants expressing said protein. A further object of the invention is the use of the protein, or of compositions containing the same, as a plant protectant, biopesticide for inducing resistance of plants to viral, microbial phytopathogens and pests.Type: ApplicationFiled: December 17, 2004Publication date: August 16, 2007Inventors: Vitaly Dzhavakhia, Alexei Filippov, Konstantin Skryabin, Tatiana Voinova, Maria Kouznetsova, Olga Shulga, Daria Shumilina, Ksenia Kromina, Mikhail Pridanniko, Natalia Battchikova, Timo Korpela
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Publication number: 20070092873Abstract: The present invention relates to methods using HIPK1 sequences for use in diagnosis and treatment of lymphoma and leukemia. In, addition, the present invention describes the use of these compositions for use in screening methods.Type: ApplicationFiled: July 2, 2003Publication date: April 26, 2007Inventors: Alexey Khanifovich Baymiev, Alexey Chemeris, Dmitry Chemeris, Timo Korpela, Nikolai Usanov, Vener Vakhitov
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Publication number: 20060280732Abstract: The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of mammalian alpha-fetoprotein (AFP) and albumin. Peptides mimicking the active site contain two sequences, Arg-Gly-Asp and Asp-X-X-Asp, wherein X means any amino acid. These sequences are needed in the same molecule for causing a wide range of biological activities. The peptides can be utilized to suppress apoptotic pathways by inhibiting the cytochrome c-mediated caspase activation. Thus, the peptides can be used to inhibit effects of apoptosis induced by oxidative stress, drugs, cytokines, Fas-ligand, alpha-fetoprotein, used to prevent apoptosis in culturing cells, in organ transplantation, in immunological autoimmune disorders and immunodeficiency syndrome induced by viral infection, or to diminish side cytotoxic effects after chemotherapy and radiation therapy.Type: ApplicationFiled: October 7, 2003Publication date: December 14, 2006Inventors: Elena Dudich, Lidia Semenkova, Igor Dudich, Edvward Tatulov, Dimitry Zubov, Timo Korpela
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Publication number: 20060165654Abstract: The present invention provides peptide and recombinant protein mimetics specifically representing the antiviral and antiproliferative activities of interferons with avoiding interferons' undesirable side effects during treatment of a variety of diseases. The basic embodiment of the present invention was to link together, through a short artificial spacer, two primary protein sequences locating distant to each other in the interferon's native structure.Type: ApplicationFiled: October 7, 2003Publication date: July 27, 2006Inventors: Vladimir Zavyalov, Dmitrity Dolgikh, Timo Korpela, Mikhail Kirpichinikov, Rita Cherkova, Ziedulla Abdullaev
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Publication number: 20060106198Abstract: The present invention provides antimicrobials for efficient therapy of infections caused by bacterial pathogens. The antimicrobials include peptides corresponding to the active site of N-terminal extension of subunits composing specific adhesive organelles of virulence of pathogenic bacteria. These antimicrobial peptides inhibit surface expression of adhesive organelles and thus prevent development of infections caused by pathogenic bacteria. The invention describes also effective methods for screening molecules preventing the generation of the adhesive organelles.Type: ApplicationFiled: July 14, 2003Publication date: May 18, 2006Inventors: Timo Korpela, Anton Zavialov, Vladimir Zav'yalov
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Publication number: 20060096866Abstract: Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.Type: ApplicationFiled: December 5, 2005Publication date: May 11, 2006Applicant: LABMASTER LTD.Inventors: Timo Ala-Kleme, Philip Canty, Jarkko Eskola, Timo Korpela, Sakari Kulmala, Piia Vainio
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Patent number: 7005108Abstract: Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.Type: GrantFiled: April 24, 2002Date of Patent: February 28, 2006Assignee: Labmaster Ltd.Inventors: Timo Ala-Kleme, Philip Canty, Jarkko Eskola, Timo Korpela, Sakari Kulmala, Piia Vainio
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Patent number: 6998479Abstract: The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD—(X—Y—ONH2)n, wherein CD is mono- or polydeoxy ?-, ?-, or ?-cyclodextrin, carrying in its 6-, 3- and/or 2-position a group containing the aminooxy group, and optionally carrying substituents different from (X—Y—ONH2). Y is a linker group between the aminooxy group and the mono- or polydeoxy-CD group, X is a functional group or an atom necessary to connect the linker Y and the deoxy CD group, or Y is a direct bond when X is a direct bond, and n is ?1, but ?24, 21 and 18 for ?-, ?- or ?-cyclodextrin, respectively, the protected aminooxy derivatives thereof, as well the methods for their preparation and use.Type: GrantFiled: March 4, 1999Date of Patent: February 14, 2006Inventors: Alexei Khomutov, Dmitry Yakovlev, Radii Khomutov, Timo Korpela
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Patent number: 6933378Abstract: A primary object of this invention is to provide a method which will enable to coexpress simultaneously two (or more) desired genes in plant, animal or yeast cells, in transgenic plants and animals, or in vitro, in plant cell-derived or animal cell-derived translation systems. This objection is to be accomplished by utilizing sequence elements derived from RNAs of a tobamovirus upstream of MP gene or CP gene termed here as IRESMP and IRESCP , respectively. The method of this invention involves the construction of a recombinant nucleic acid sequence which comprises a specific transcriptional promoter, a first gene expressible in eukaryotic cells linked to said transcriptional promoter, IRESMP or IRESCP located 3? to the first gene and a second gene expressible in eukaryotic cells, located 3? to IRES sequence such that the second gene is placed under the transcriptional control of IRES sequence originated from tobamovirus genome.Type: GrantFiled: July 25, 2001Date of Patent: August 23, 2005Inventors: Joseph Atabekov, Timo Korpela, Yurii Dorokhov, Peter Ivanov, Maxim Skulachev, Nina Rodionova, Olga Karpova
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Patent number: 6919198Abstract: The present invention provides bacterial strains for secretion of soluble biologically active recombinant heterologous proteins into periplasm or on a surface/into a cultivation medium of bacteria. The invention exploits the secretion system of Gram-negative bacteria including periplasmic chaperones and usher/secretin proteins. For accomplishing the aim, the bacterial strains simultaneously express the fusion protein (signal peptide)-(mature hecterologous protein)-(subunit of a bacterial surface structure, Caf1), periplasmic chaperone specific for the subunit, and outer membrane usher/secretin protein specific for the subunit. Secretion of fusion proteins: (signal peptide of Caf1)-(mature human IL-1?)-(mature Caf1), (signal peptide of Caf1)-(mature human GM-CSF)-(mature Caf1), and (signal peptide of Caf1)-(mature human IL-1ra)-(mature Caf1) that were expressed in Escherichia coli simultaneously with the periplasmic chaperone Caf1M and the usher/secretin protein Caf1A are examples of the use of the invention.Type: GrantFiled: May 3, 2000Date of Patent: July 19, 2005Assignee: Biotecnol S.A.Inventors: Timo Korpela, Sheila Macintyre-Ayane, Anton Zavialov, Natalia Battchikova, Lada Petrovskaya, Vladimir Zav'yalov, Galina Petrovna Korobko, Vyacheslav Korobko
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Publication number: 20050143293Abstract: The present invention is related to novel bioactive pentapeptides, pentarphins, the main indication of which is enhancing phagocytic activity of macrophages against microbes. In particular, the cyclopentapeptide, cyclo(Val-Lys-Gly-Phe-Tyr), termed cyclopeptarphin, was 100 times more active than tuftsin. Cyclopentarphin was non-toxic even at concentrations 1000 times higher than the minimum active dose, while being non-immunogenic. Furthermore, cyclopentarphin is more stable to enzymatic cleavage in vitro as compared to linear pentarphin and tuftsin and, hence, its life span in vivo is also larger than that of linear peptides. High efficacy and safety of cyclopentarphin enable elaboration of novel drugs that enhance the resistance of human and animal organisms to microbes and micro particles.Type: ApplicationFiled: January 23, 2003Publication date: June 30, 2005Inventors: Timo Korpela, Elena Navolotskaya, Tatiana Zargarova, Petrovich Zavyalov
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Publication number: 20040101868Abstract: The inventions deals with determination of the human hemochromatosis gene (HFE) mutation (C282Y of HFE protein), responsible for the disease of hereditary hemochromatosis. The invention is important in diagnosis and risk assessment for this disease. The method consists of a single-tube high-throughput PCR assay for the detection of C282Y. We invented that it is advantageously possible to combine three concepts each known separately in prior art from different sources: allele specific PCR, mutagenically separated PCR, and amplicon identification by specific dissociation curves. Analysis can be performed in either a conventional or fluorescence-detecting thermocycler using the same primers, reactant constituents and cycling protocol. PCR products are identified either by their length or melting temperature (Tm). Primer cross reactions are prevented by deliberate primer: primer and primer: template mismatches.Type: ApplicationFiled: February 21, 2003Publication date: May 27, 2004Inventors: Veli Kairisto, Gerard Donohoe, Jarkko Eskola, Timo Korpela
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Patent number: 6645776Abstract: The excitation of label molecules usable in chemical and biochemical analysis by electrical pulses at electrodes covered with a thin insulating film, and the use of such electrodes in chemical, clinical and biochemical analysis. The electrodes include a conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films, so that either one or several label compounds can be excited to an excited state which is deexcited by emission of ultraviolet, visible or infrared light, in aqueous solution providing the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.Type: GrantFiled: February 9, 2001Date of Patent: November 11, 2003Assignee: Labmaster OyInventors: Sakari Kulmala, Timo Ala-Kleme, Jarkko Eskola, Timo Korpela