Abstract: 2-Hydroxy-isocaproic acid (HICA), or an ester or amide derivative, an enantiomer or a pharmaceutically acceptable salt thereof, for use in prevention and/or treatment of a disease or condition involving degradation of cartilage and/or disruption of cartilage homeostasis and/or integrity is disclosed.

Abstract: 2-Hydroxy-isocaproic acid (HICA), or an ester or amide derivative, an enantiomer or a pharmaceutically acceptable salt thereof, for use in prevention and/or treatment of a disease or condition involving degradation of cartilage and/or disruption of cartilage homeostasis and/or integrity is disclosed.

Abstract: The present invention relates to a novel MMP-8 activation product such as a MMP-8 middle-part activation product. The invention also relates to detecting such a MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject and to the use thereof for diagnosing diseases which relate to abnormal or elevated levels of activated MMP-8.

Abstract: 2-Hydroxy-isocaproic acid (HICA), or an ester or amide derivative, an enantiomer or a pharmaceutically acceptable salt thereof, for use in prevention and/or treatment of a disease or condition involving degradation of cartilage and/or disruption of cartilage homeostasis and/or integrity is disclosed.

Abstract: The present invention relates to a novel MMP-8 activation product such as a MMP-8 middle-part activation product. The invention also relates to detecting such a MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject and to the use thereof for diagnosing diseases which relate to abnormal or elevated levels of activated MMP-8.

Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.

Abstract: The present invention relates to a novel method for determining risk of cardiovascular diseases comprising detecting of MMP-8 and CRP in a sample, and comparing the detected amounts with respective predetermined values of MMP-8 and CRP, wherein the detection of elevated levels of MMP-8 and CRP is indicative of presence or risk of cardiovascular event or disease. The present invention relates also to the use of detection of MMP-8 and CRP for predicting a risk for getting a cardiovascular event, for monitoring the effect of therapy on cardiovascular event or on cardiovascular disease, or for detecting the presence of a subclinical cardiovascular disease. Also, a method for constructing a risk prediction model for a presence of CVD disease or a risk of CVD events is presented.

Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.

Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.

Abstract: A process for avoiding false positive results in a detecting process of an inflammation indicator from the matrix metalloproteinase (MMP) family in a gingival crevicular fluid (GCF), wherein said GCF, which is obtained from a mouthrinse or saliva, is filtered before said inflammation indicator from the MMP family is assayed.

Abstract: Methods and systems for managing metadata are described. The method comprises steps of receiving a request from an application to access a metadata attribute corresponding to a piece of content, determining whether the application is authorized to access the metadata attribute, retrieving the metadata attribute upon determining that the application is authorized to access the metadata attribute, and transmitting the metadata attribute to the application. A metadata storage medium may be accessed and searched for the metadata attribute. A system for associating content data, context data, and an event is also described. The system allows for a user to search for content data based upon context data. Another method for associating data is described. The method includes steps of initiating a mufti-media call session, initiating an application independent of the mufti-media call session, and associating collected metadata from the application and the mufti-media call session.

Abstract: The invention relates to a method for controlling swaying and swinging of a spreader in a crane and the load attached thereto, the crane comprising: a trolley, hoist gears, hoisting ropes, on which the spreader is suspended from the trolley, auxiliary gears provided with motors and motor control equipment and auxiliary ropes, and in which method the forces of the auxiliary ropes exerted on the spreader are controlled by moving the auxiliary ropes using the auxiliary gears by means of torque instructions (Tcontrol) obtained on the basis of the rope forces (Frope) of the auxiliary ropes and the rotating speed data of the auxiliary gears, and whereby the rotating speed data of each auxiliary gear is formed gear-specifically as the difference between the measured rotating speed (nact) of the auxiliary gear and the calculated rotating speed (ncalc) of the auxiliary gear.

Abstract: The invention relates to a method for controlling swaying and swinging of a spreader in a crane and the load attached thereto, the crane comprising: a trolley, hoist gears, hoisting ropes, on which the spreader is suspended from the trolley, auxiliary gears provided with motors and motor control equipment and auxiliary ropes, and in which method the forces of the auxiliary ropes exerted on the spreader are controlled by moving the auxiliary ropes using the auxiliary gears by means of torque instructions (Tcontrol) obtained on the basis of the rope forces (Frope) of the auxiliary ropes and the rotating speed data (n) of the auxiliary gears, and whereby the torque instruction of the motor control equipment in each auxiliary gear is formed gear-specifically as a sum of a static (Tstat) and a dynamic (Tdyn, calc) term.

Abstract: Music and non-music portions in an audio stream are identified. The audio stream is digitized and segmented into frames. Selected frames are passed through a filter bank which includes filters having bandwidths approximately proportional to their center frequencies. The spectral flux for each selected frame is calculated and smoothed. Frames having a smoothed spectral flux below a threshold value are associated with music, and frames having a smoothed spectral flux above a threshold value are associated with non-music.

Abstract: The invention relates to a method for controlling swaying and swinging of a spreader in a crane and the load attached thereto, the crane comprising: a trolley, hoist gears, hoisting ropes, on which the spreader is suspended from the trolley, auxiliary gears provided with motors and motor control equipment and auxiliary ropes, and in which method the forces of the auxiliary ropes exerted on the spreader are controlled by moving the auxiliary ropes using the auxiliary gears by means of torque instructions (Tcontrol) obtained on the basis of the rope forces (Frope) of the auxiliary ropes and the rotating speed data of the auxiliary gears, and whereby the rotating speed data of each auxiliary gear is formed gear-specifically as the difference between the measured rotating speed (nact) of the auxiliary gear and the calculated rotating speed (ncalc) of the auxiliary gear.

Abstract: Methods and systems for managing metadata are described. The method comprises steps of receiving a request from an application to access a metadata attribute corresponding to a piece of content, determining whether the application is authorized to access the metadata attribute, retrieving the metadata attribute upon determining that the application is authorized to access the metadata attribute, and transmitting the metadata attribute to the application. A metadata storage medium may be accessed and searched for the metadata attribute. The metadata storage medium may be encrypted to provide additional security.

Abstract: The invention relates to a method for controlling swaying and swinging of a spreader in a crane and the load attached thereto, the crane comprising: a trolley (1), hoist gears (2), hoisting ropes (4), on which the spreader (7) is suspended from the trolley (1), auxiliary gears (10) provided with motors and motor control equipment and auxiliary ropes (12), and in which method the forces of the auxiliary ropes exerted on the spreader are controlled by moving the auxiliary ropes using the auxiliary gears by means of torque instructions (Tcontrol) obtained on the basis of the rope forces (Frope) of the auxiliary ropes and the rotating speed data of the auxiliary gears, and whereby the rotating speed data of each auxiliary gear (10) is formed gear-specifically as the difference between the measured rotating speed (nact) of the auxiliary gear and the calculated rotating speed (ncal) of the auxiliary gear.

Abstract: Music and non-music portions in an audio stream are identified. The audio stream is digitized and segmented into frames. Selected frames are passed through a filter bank which includes filters having bandwidths approximately proportional to their center frequencies. The spectral flux for each selected frame is calculated and smoothed. Frames having a smoothed spectral flux below a threshold value are associated with music, and frames having a smoothed spectral flux above a threshold value are associated with non-music.

Abstract: The present invention relates to novel matrix metalloproteinase (MMP) inhibitors and down-regulators, to a process for the preparation of these inhibitors, to pharmaceutical compositions comprising these inhibitors/down-regulators, to the use of the novel MMP inhibitors for the manufacture of pharmaceutical and research preparations, to a method for inhibiting and down-regulating MMP-dependent conditions either in vivo or in vitro, to a method for inhibiting formation, synthesis, expression activations, and/or functions as well as actions of matrix metalloproteinases, and to the use of the novel MMP inhibitors and down-regulators in biochemical isolation and purification procedures of matrix metalloproteinases.

Abstract: The present invention discloses methods and test kits which are useful tools for the dentist and provide means for evaluating the periapical disease activity or inflammation and monitoring the need of continued or alternative medical treatment before finalizing the root treatment in teeth by measuring the presence or absence of MMPs in root canal exudates. The test kit is preferably constructed for chair-side use.