Patents by Inventor Timothy A. Ayers

Timothy A. Ayers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11802276
    Abstract: Disclosed are methods for isolating polymerase complexes from a mixture of polymerase complex components. The polymerase complexes can comprise a nanopore to provide isolated nanopore sequencing complexes. The methods relate to the positive and negative isolation of the polymerase complexes and/or nanopore sequencing complexes. Also disclosed is a nucleic acid adaptor for isolating active polymerase complexes, polymerase complexes comprising the nucleic acid adaptor, and methods for isolating active polymerase complexes using the nucleic acid adaptor.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: October 31, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Helen Franklin, Cynthia Cech, Timothy Kellogg Craig, Aruna Ayer, Kirti Dhiman, Natalie B. Chechelski Johnston, Joshua N. Mabry, Arkadiusz Bibillo, Peter Crisalli, Randall W. Davis
  • Patent number: 11746337
    Abstract: Disclosed are methods for isolating polymerase complexes from a mixture of polymerase complex components. The polymerase complexes can comprise a nanopore to provide isolated nanopore sequencing complexes. The methods relate to the positive and negative isolation of the polymerase complexes and/or nanopore sequencing complexes. Also disclosed is a nucleic acid adaptor for isolating active polymerase complexes, polymerase complexes comprising the nucleic acid adaptor, and methods for isolating active polymerase complexes using the nucleic acid adaptor.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: September 5, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Helen Franklin, Cynthia Cech, Timothy Kellogg Craig, Aruna Ayer, Kirti Dhiman, Natalie B. Chechelski Johnston, Joshua N. Mabry, Arkadiusz Bibillo, Peter Crisalli, Randall W. Davis
  • Patent number: 8993602
    Abstract: The invention relates to a benzoic acid salt of methyl(2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate, and to a benzoic acid salt of methyl(2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: March 31, 2015
    Assignee: Sanofi
    Inventors: Norbert Nagel, Bruno Baumgartner, Harald Berchtold, Timothy Ayers
  • Publication number: 20140024684
    Abstract: The invention relates to a benzoic acid salt of methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate, and to a benzoic acid salt of methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
    Type: Application
    Filed: March 27, 2012
    Publication date: January 23, 2014
    Applicant: SANOFI
    Inventors: Norbert Nagel, Bruno Baumgartner, Harald Berchtold, Timothy Ayers
  • Patent number: 7091199
    Abstract: The compounds are of the class of thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: August 15, 2006
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: George E. Lee, John G. Jurcak, Timothy A. Ayers
  • Patent number: 6930197
    Abstract: This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 16, 2005
    Assignee: Aventis Pharmaceuticals Inc.
    Inventor: Timothy A. Ayers
  • Patent number: 6730791
    Abstract: This invention relates to novel compounds of the following formula and a process for the preparation thereof. wherein X is Cl, Br or I.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: May 4, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventor: Timothy A. Ayers
  • Patent number: 6700012
    Abstract: This invention relates to compounds of the formula: wherein R1 is H or C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; R2 and R3 are each independently C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; or stereoisomers thereof.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: March 2, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventor: Timothy A. Ayers
  • Patent number: 6689898
    Abstract: This invention relates to novel compounds of the formula: wherein R1 is H or C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; R2 and R3 are each independently C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; X is Cl, Br or I; or stereoisomers thereof.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: February 10, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventor: Timothy A. Ayers
  • Patent number: 6683094
    Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: January 27, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Patent number: 6673933
    Abstract: This invention relates to novel compounds of formula: wherein R1 is H or C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; R2 and R3 are each independently C1-C6alkyl and the C1-C6alkyl moiety is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: January 6, 2004
    Assignee: Aventis Pharmaceutical Inc.
    Inventor: Timothy A. Ayers
  • Publication number: 20030069423
    Abstract: Novel processes for the preparation of adenosine compounds and intermediates thereto. The adenosine compounds prepared by the present processes may be useful as cardiovascular agents, more particularly as antihypertensive and anti-ischemic agents, as cardioprotective agents which ameliorate ischemic injury or myocardial infarct size consequent to myocardial ischemia, and as an antilipolytic agents which reduce plasma lipid levels, serum triglyceride levels, and plasma cholesterol levels. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
    Type: Application
    Filed: May 10, 2002
    Publication date: April 10, 2003
    Inventors: Timothy A. Ayers, Geoffrey A. D'Netto, Gregory G. Kubiak, James J. Mencel, Michael K. O'Brien, Matthew R. Powers, John J. Shay, Adam W. Sledeski, David S. Teager, Benoit Vanasse
  • Publication number: 20030022919
    Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof.
    Type: Application
    Filed: June 12, 2002
    Publication date: January 30, 2003
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Publication number: 20020111513
    Abstract: This invention relates to a process for the preparation of compounds of the formula: 1
    Type: Application
    Filed: March 22, 2002
    Publication date: August 15, 2002
    Inventor: Timothy A. Ayers
  • Publication number: 20020099077
    Abstract: This invention relates to novel compounds of formula: 1
    Type: Application
    Filed: March 22, 2002
    Publication date: July 25, 2002
    Inventor: Timothy A. Ayers
  • Publication number: 20020099091
    Abstract: This invention relates to novel compounds of the formula: 1
    Type: Application
    Filed: March 22, 2002
    Publication date: July 25, 2002
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Publication number: 20020099088
    Abstract: This invention relates to novel compounds of the following formula and a process for the preparation thereof.
    Type: Application
    Filed: March 22, 2002
    Publication date: July 25, 2002
    Inventor: Timothy A. Ayers
  • Publication number: 20020099090
    Abstract: This invention relates to compounds of the formula: 1
    Type: Application
    Filed: March 22, 2002
    Publication date: July 25, 2002
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Patent number: 6407119
    Abstract: This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 18, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Timothy A. Ayers, Paul W. Brown
  • Patent number: 5698696
    Abstract: This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.
    Type: Grant
    Filed: March 7, 1996
    Date of Patent: December 16, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gilbert Marciniak, Richard A. Schnettler, Timothy A. Ayers, Damian J. Krysan