Abstract: The invention provides an article, such as an aerosol-generating smoking article that does not combust tobacco, that includes a tobacco rod and a filter element connected to the tobacco rod, the filter element having an end proximal to the tobacco rod and an end distal from the tobacco rod, wherein the filter element includes a first section of filter material and a second section of filter material, and further includes a smoke-altering flavorant.

Abstract: The present disclosure provides aerosol generating substrates and aerosol source members comprising aerosol generating substrates, as well as methods of manufacturing thereof. In an example implementation, an aerosol generating substrate may comprise a fibrous filler material, an aerosol forming material, and a plurality of heat conducting constituents, wherein the substrate is formed as a sheet, and wherein the heat conducting constituents are part of the sheet. The heat conducting constituents may be incorporated within the sheet, or may be formed on a surface of the sheet. In another example implementation, an aerosol source member may comprise a substrate portion formed of a collection of intermingled pieces cut from an aerosol substrate sheet. In addition, or alternatively, a substrate portion may be formed of a series of overlapping layers of an aerosol substrate sheet.

Abstract: Smoking articles, and methods for forming such smoking articles, such as an electronic smoking article, are provided. An exemplary smoking article comprises a control body portion having a control body engagement end, and having a first control component therein. A cartridge body portion includes a cartridge body engagement end configured to removably engage the control body engagement end of the control body portion. The cartridge body portion further includes a consumable arrangement comprising at least an aerosol precursor composition and at least one heating element operably engaged therewith, and a second control component. At least the consumable arrangement is configured to be in communication with the first control component upon engagement between the cartridge body and control body portions.

Abstract: The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided.

Abstract: An electrolyte solution for use in a battery includes at least: an ionizable salt; at least one organic solvent; and at least one cyclic phosphazene compound.

Abstract: Methods of using monoclinic crystals of human beta-secretase (BACE) having unit cell dimensions of a, b, and c, wherein a is about 81±20 ? to about 101 ?, b is 103±20 ?, c is 100±20 ?, and ?=?=90°, and ? is 105°±10° for crystals of symmetry P21 and a=73.1, b=105.1, c=50.5 ? and ? is 94.8° for crystals of C2 symmetry in drug screening assays comprising selecting a potential modifier by adding the potential modifiers to an aqueous mixture of the crystal and detecting a measure of binding, such that the potential modifier that binds is selected as a potential drug.

Abstract: The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.

Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.

Abstract: A scaffold plank comprising a rectangularly configured main body which defines opposed ends, and a pair of end caps secured to respective ones of the opposed ends of the main body. Both the main body and the end caps are preferably fabricated from a recycled/recyclable plastic material. Additionally, the main body may be provided with one or more internal steel reinforcement bars for purposes of selectively increasing the level of structural integrity/rigidity thereof.

Abstract: A scaffold plank comprising a rectangularly configured main body which defines opposed ends, and a pair of end caps secured to respective ones of the opposed ends of the main body. Both the main body and the end caps are preferably fabricated from a recycled/recyclable plastic material. Additionally, the main body may be provided with one or more internal steel reinforcement bars for purposes of selectively increasing the level of structural integrity/rigidity thereof.

Abstract: A scaffold plank comprising an elongate main body having a top wall which defines a central axis and includes a plurality of openings disposed therein along the central axis. Attached to the top wall is an opposed pair of side walls, while attached to at least the top wall and extending between the side walls is a reinforcement structure. The main body is fabricated solely from a plastic material. Additionally, each of the openings is adapted to accommodate a locking pin which allows two or more scaffold planks to be releasably engaged to each other.

Abstract: An electric reflector-type lamp having an improved eyelet construction in which there is utilized a uniquely contoured eyelet fitted into specially shaped apertures in the rear of the glass reflector. The eyelets consist of a hollow cylinder of brass with a bulged center portion which is held firmly within each aperture. The end portions of the eyelet are flared to permanently hold the eyelet in position after insertion. The apertures in the rear of the reflector are comprised of a plurality of sections which accommodate the eyelet and promote sturdy construction. A light source capsule is guided into the apertures by the flared ends of the eyelets, after which the leads are soldered to the eyelets. To seal the lamp and for additional strength, an adhesive can be added around the eyelet.

Abstract: An electric reflector-type lamp having an improved eyelet construction in which there is utilized a uniquely contoured eyelet fitted into specially shaped apertures in the rear of the glass reflector. The eyelets consist of a hollow cylinder of brass with a bulged center portion which is held firmly within each aperture. The end portions of the eyelet are flared to permanently hold the eyelet in position after insertion. The apertures in the rear of the reflector are comprised of a plurality of sections which accommodate the eyelet and promote sturdy construction. A light source capsule is guided into the apertures by the flared ends of the eyelets, after which the leads are soldered to the eyelets. To seal the lamp and for additional strength, an adhesive can be added around the eyelet.

Abstract: A high-voltage, low-wattage incandescent lamp having a tubular hard-glass envelope enclosing a coiled coil filament axially mounted with at least one, preferably two, intermediate filamentary supports. The lead-in wires and filamentary supports are mounted in the press seal of the lamp. Each end of the filament is mounted on an internal termination of a lead-in wire. The filament is mounted on the intermediate support(s) at point(s) along the filament body such that the body is divided into approximately equal segments or such that the operating temperature along the body is approximately uniform. Because of reduced filament sag, the tubular glass envelope has a reduced inner diameter and thinner wall thickness whereby the lamp may be more safely contained within an outer envelope in the unlikely event of a lamp burst. A lamp in accordance with the invention will exhibit enhanced operating characteristics and is well suited for applications in Europe.

Abstract: A multifunctional member and reflector lamp employing same for mounting a light-source capsule on the inside of the neck of the outer envelope, for optically aligning the capsule with respect to the reflector, for reflecting heat away from the base region of the lamp, for blocking convective heat transfer into the lamp neck, and for reflecting light incident on the member toward the lens. In performing these multiple functions, the member reflects heat back to the filament or light source which improves its efficiency, and the member redirects light toward the lens which improves the efficacy of the lamp. In a preferred embodiment, the multifunctional member is formed from stainless steel and has a bowl-shaped body with a somewhat flexible peripheral annular tab extending upward and outward conically. The peripheral tab may be crimped, slotted, or have a tapered thickness in order to provide flexibility sufficient for mounting.