Abstract: Glasses comprising SiO2, Al2O3, and P2O5 that are capable of chemical strengthened by ion exchange and having high damage resistance. These phosphate-containing glasses have a structure in which silica (SiO2) is replaced by aluminum phosphate (AlPO4) and/or boron phosphate (BPO4).

Abstract: Described herein are variants of alpha-hemolysin having at least one amino acid substitution at H35G, E111N, M113A, and/or K147N in the mature, wild-type alpha-hemolysin amino acid sequence. In certain examples, the variant may have a substitution at E111S, M113S, T145S, K147S, or L135I in the mature alpha-hemolysin amino acid sequence. The ?-hemolysin variants may also include a substitution at H144A and/or a series of glycine residues spanning residues 127 to 131 of the mature, wild-type alpha hemolysin. Also provided are nanopore assemblies including the alpha-hemolysin variants, the assembly having an increased nanopore lifetime. Further, provided are variants that, in addition to providing increased lifetime, provide a decreased time-to-thread. Hence, the variants provided herein both increase nanopore lifetime and improve efficiency and accuracy of DNA sequencing reactions using nanopores comprising the variants.

Abstract: Described herein are variants of alpha-hemolysin having at least one amino acid substitution at H35G, E111N, M113A, and/or K147N in the mature, wild-type alpha-hemolysin amino acid sequence. In certain examples, the variant may have a substitution at E111S, M113S, T145S, K147S, or L135I in the mature alpha-hemolysin amino acid sequence. The ?-hemolysin variants may also include a substitution at H144A and/or a series of glycine residues spanning residues 127 to 131 of the mature, wild-type alpha hemolysin. Also provided are nanopore assemblies including the alpha-hemolysin variants, the assembly having an increased nanopore lifetime. Further, provided are variants that, in addition to providing increased lifetime, provide a decreased time-to-thread. Hence, the variants provided herein both increase nanopore lifetime and improve efficiency and accuracy of DNA sequencing reactions using nanopores comprising the variants.

Abstract: A method for designing the cross-sectional shape of the fuselage of a flying body having the fuselage extending in the roll axial direction, the section being taken on a plane perpendicular to the roll axial direction. This method is provided with: an initial setting step S12 for setting an initial cross-sectional shape, which is the initial cross-sectional shape of the fuselage having a cross-sectional shape that is not truly circular; load application steps S14, S21, S28 for analytically or experimentally preloading the fuselage having the initial cross-sectional shape; and a design shape setting step S17 for acquiring the cross-sectional shape of the preloaded fuselage as the design cross-sectional shape of the fuselage.

Abstract: A virtual camera placement system is provided which includes a user input device configured to receive user input and a display device configured to display images captured by a virtual camera. The virtual camera placement system further includes non-volatile memory configured to store instructions and a processor configured to execute the instructions to generate a three-dimensional simulation including a plurality of challenge points for a user, navigate the simulation including the challenge points in response to the user input, and control the virtual camera in the simulation differently in a plurality of camera stages based on at least the user input and an outcome of navigating one or more of the challenge points.

Abstract: Described herein are nanopore protein conjugates that can be used in DNA sequencing reactions. The nanopore protein conjugates includes a nanopore protein monomer that is joined to a DNA binding domain. The nanopore protein monomer is available to oligomerize with other nanopore protein monomers, while the DNA binding domain is available to bind to a template DNA strand. In certain examples, the nanopore protein monomer is an alpha-hemolysin monomer or variant thereof and the DNA binding domain is an Sso7d protein or variant thereof, such as an Sso7d-like protein. Also provided are nanopore protein assemblies incorporating the nanopore protein conjugates, along with methods of using the nanopore protein assemblies in sequencing reactions.

Abstract: Described herein are variants of alpha-hemolysin having at least one amino acid substitution at H35G, E111N, M113A, and/or K147N in the mature, wild-type alpha-hemolysin amino acid sequence. In certain examples, the variant may have a substitution at E111S, M113S, T145S, K147S, or L1351 in the mature alpha-hemolysin amino acid sequence. The ?-hemolysin variants may also include a substitution at H144A and/or a series of glycine residues spanning residues 127 to 131 of the mature, wild-type alpha hemolysin. Also provided are nanopore assemblies including the alpha-hemolysin variants, the assembly having an increased nanopore lifetime. Further, provided are variants that, in addition to providing increased lifetime, provide a decreased time-to-thread. Hence, the variants provided herein both increase nanopore lifetime and improve efficiency and accuracy of DNA sequencing reactions using nanopores comprising the variants.

Abstract: The present invention relates generally to medical equipment, more particularly, the use of fluid hoses coupling tanks to cannulas, as part of medical gas therapy, such as oxygen therapy. The invention describes a collection system for managing excess flexible hose that a patient might need to wear for medical reasons such as home oxygen medical therapy. It comprises a non-spooling roller system attached to a receptacle for collecting excess hose into the receptacle and extraction from the receptacle, and a power system to power and control the roller system, and design features that optimize the collection and extraction.

Abstract: Described herein are variants of alpha-hemolysin having at least one amino acid substitution at H35G, E111N, M113A, and/or K147N in the mature, wild-type alpha-hemolysin amino acid sequence. In certain examples, the variant may have a substitution at E111S, M113S, T145S, K147S, or L1351 in the mature alpha-hemolysin amino acid sequence. The ?-hemolysin variants may also include a substitution at H144A and/or a series of glycine residues spanning residues 127 to 131 of the mature, wild-type alpha hemolysin. Also provided are nanopore assemblies including the alpha-hemolysin variants, the assembly having an increased nanopore lifetime. Further, provided are variants that, in addition to providing increased lifetime, provide a decreased time-to-thread. Hence, the variants provided herein both increase nanopore lifetime and improve efficiency and accuracy of DNA sequencing reactions using nanopores comprising the variants.

Abstract: An apparatus for manipulating particles includes: a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube connecting to a drum at the rear side of the rotor; a flexible conduit residing in the guide tube; and first and second elongate passageways for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.

Abstract: Cable robots may be used to automatically load items onto one or more surfaces in any environment. An item may be received on a carrier that is connected to tensioning actuators of a cable robot by one or more cables in tension. The actuators of the robot may be manipulated in concert to move the carrier from a first position to a second position, which may be fixed or in motion, at which the item may be expelled from the carrier. The carrier may include induction wheels and/or conveyors for receiving the item thereon and for expelling the item therefrom. The cable robot may be provided in series with a conveyor and mounted to a frame, and used to load items onto a delivery vehicle, such that the frame may be withdrawn as items are loaded.

Abstract: A portable aircraft maintenance stand includes a frame assembly and a deck. The frame assembly has a base portion and an upper portion. The deck is mounted to the upper portion of the frame assembly and includes a cantilevered portion. The deck also has a gap configured to receive an engine of an aircraft such that the deck at least partially wraps around the engine. The cantilevered portion of the deck is configured to be positioned vertically above a wing of the aircraft while the base portion of the frame assembly is positioned vertically below the wing.

Abstract: A token dispensing system is adapted suitable for installing a token dispenser in a game device. A mounting bracket for the token dispenser provides a simple and inexpensive way to install the token dispenser as part of the token dispensing system inside the housing of a game device. The dispensing system includes an electronic control circuit that controls an alarm device to provide a low level warning signal when the level of tokens in the token dispenser is low and an empty warning signal when the token dispenser is empty. The electronic control circuit controls dispensing tokens from the token dispenser such that a user receives the correct number of tokens even if the dispenser runs out of tokens in the middle of dispensing a selected number of tokens during a transaction.

Abstract: Described herein are variants of alpha-hemolysin having at least one amino acid substitution at H35G, E111N, M113A, and/or K147N in the mature, wild-type alpha-hemolysin amino acid sequence. In certain examples, the variant may have a substitution at E111S, M113S, T145S, K147S, or L1351 in the mature alpha-hemolysin amino acid sequence. The a-hemolysin variants may also include a substitution at H144A and/or a series of glycine residues spanning residues 127 to 131 of the mature, wild-type alpha hemolysin. Also provided are nanopore assemblies including the alpha-hemolysin variants, the assembly having an increased nanopore lifetime. Further, provided are variants that, in addition to providing increased lifetime, provide a decreased time-to-thread. Hence, the variants provided herein both increase nanopore lifetime and improve efficiency and accuracy of DNA sequencing reactions using nanopores comprising the variants.

Abstract: The present invention relates generally to medical equipment, more particularly, the use of fluid hoses coupling tanks to cannulas, as part of medical gas therapy, such as oxygen therapy. The invention describes a collection system for managing excess flexible hose that a patient might need to wear for medical reasons such as home oxygen medical therapy. It comprises a non-spooling roller system attached to a receptacle for collecting excess hose into the receptacle and extraction from the receptacle, and a power system to power and control the roller system, and design features that optimize the collection and extraction.

Abstract: A virtual camera placement system is provided which includes a user input device configured to receive user input and a display device configured to display images captured by a virtual camera. The virtual camera placement system further includes non-volatile memory configured to store instructions and a processor configured to execute the instructions to generate a three-dimensional simulation including a plurality of challenge points for a user, navigate the simulation including the challenge points in response to the user input, and control the virtual camera in the simulation differently in a plurality of camera stages based on at least the user input and an outcome of navigating one or more of the challenge points.

Abstract: The present invention relates generally to medical equipment, more particularly, the use of fluid hoses coupling tanks to cannulas, as part of medical gas therapy, such as oxygen therapy. The invention describes a collection system for managing excess flexible hose that a patient might need to wear for medical reasons such as home oxygen medical therapy. It comprises a collection container, a non-spooling roller system for collecting excess hose into the collection container and extraction from the collection container, and power system to power and control the roller system.

Abstract: A heating system for an automotive passenger cabin includes a blower fan generating an air flow; a first heater core downstream of the blower fan; a second heater core downstream of the first heater core; a coolant loop with a first branch and a second branch, wherein the first heater core is disposed in the first branch and the second heater core is disposed in the second branch; a change-over valve arrangement having a first setting establishing fluid communication between the first and second heater cores by connecting the first and second branches in two locations on opposite sides of the first and second heater cores. The change-over valve arrangement has a second setting separating the fluid communication between the first and second heater cores by disconnecting the first and second branches. The second branch or both the first and the second branch are connectable to a PCM heater.

Abstract: Utilities (e.g., systems, apparatuses, methods) that reduce robotic assembly contention in media element storage libraries by translating (e.g., displacing) a robot arm of a first robotic assembly mounted over a first storage array of a storage library away from a central reference plane as the robot arm is being pivoted into a first position adjacent the first storage array to allow a robot arm of a second robotic assembly to slide or otherwise move past the robot arm of the first robotic assembly, even when the robot arms of the first and second robot arms are disposed at the same height (e.g., along a z-axis) within the storage library. For instance, a pivot member of the robot arm may be mounted on a carriage that is configured to translate between the first and second storage arrays in response to the pivot member being pivoted about a pivot axis.

Abstract: A token dispensing system is adapted suitable for installing a token dispenser in a game device. A mounting bracket for the token dispenser provides a simple and inexpensive way to install the token dispenser as part of the token dispensing system inside the housing of a game device. The dispensing system includes an electronic control circuit that controls an alarm device to provide a low level warning signal when the level of tokens in the token dispenser is low and an empty warning signal when the token dispenser is empty. The electronic control circuit controls dispensing tokens from the token dispenser such that a user receives the correct number of tokens even if the dispenser runs out of tokens in the middle of dispensing a selected number of tokens during a transaction.