Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of mediated diseases, such as cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and therapies comprising such modulators, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure, pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies and combination pharmaceuticals employing those modulators, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions, containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formulae I, II, their pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formulae I or II as effective modulators of STING are also provided.

Abstract: At least one device receives a call request from a calling party to a called party. The device routes the call request to an Internet Protocol Multimedia Subsystem (IMS) core when a first condition is met and bypasses the IMS core when a second condition is met.

Abstract: A method includes receiving a telephone number mapping query associated with a call. The method may also include generating routing information based on the query and forwarding the routing information to a control device. The routing information may indicate that processing associated with routing the call is to bypass a core portion of an Internet multimedia subsystem (IMS) when a calling party associated with the call does not invoke an IMS service, the called party associated with the call does not invoke an IMS service and the called party is not an IMS subscriber.

Abstract: A method includes receiving a telephone number mapping query associated with a call. The method may also include generating routing information based on the query and forwarding the routing information to a control device. The routing information may indicate that processing associated with routing the call is to bypass a core portion of an Internet multimedia subsystem (IMS) when a calling party associated with the call does not invoke an IMS service, the called party associated with the call does not invoke an IMS service and the called party is not an IMS subscriber.

Abstract: A method includes receiving a telephone number mapping query associated with a call. The method may also include generating routing information based on the query and forwarding the routing information to a control device. The routing information may indicate that processing associated with routing the call is to bypass a core portion of an Internet multimedia subsystem (IMS) when a calling party associated with the call does not invoke an IMS service, the called party associated with the call does not invoke an IMS service and the called party is not an IMS subscriber.

Abstract: At least one device receives a call request from a calling party to a called party. The device routes the call request to an Internet Protocol Multimedia Subsystem (IMS) core when a first condition is met and bypasses the IMS core when a second condition is met.

Abstract: A method includes receiving a telephone number mapping query associated with a call. The method may also include generating routing information based on the query and forwarding the routing information to a control device. The routing information may indicate that processing associated with routing the call is to bypass a core portion of an Internet multimedia subsystem (IMS) when a calling party associated with the call does not invoke an IMS service, the called party associated with the call does not invoke an IMS service and the called party is not an IMS subscriber.

Abstract: An apparatus for storing a packet including a buffer in which packets are stored. The apparatus includes a mechanism for determining an average buffer fill of the buffer, where the average buffer fill is an average fill state of the buffer. The determining mechanism is connected to the buffer. The apparatus includes a mechanism for calculating a drop probability associated with the packet which identify is the probability the packet will be dropped from a the buffer. The apparatus includes a mechanism for generating a random number. The apparatus includes a mechanism for discarding the packet from the elements if the drop probability is greater in than the random number. A method for access control.

Abstract: An apparatus for storing a packet. The apparatus comprises a buffer in which packets are stored. The apparatus comprises a mechanism for determining an average buffer fill of the buffer, where the average buffer fill is an average fill state of the buffer. The determining mechanism is connected to the buffer. The apparatus comprises a mechanism for calculating a drop probability associated with the packet which identify is the probability the packet will be dropped from a the buffer. The apparatus comprises a mechanism for generating a random number. The apparatus comprises a mechanism for discarding the packet from the elements if the drop probability is greater in than the random number. A method for access control. The method comprises the steps of receiving a packet at an element having a buffer.