Abstract: A detector (10; 110) is provided for mounting to a container (2) defining an internal space (6) in order to determine occupancy of the container. The detector includes a housing (12; 112), a mounting arrangement for mounting the housing to a container, a sensor arrangement comprising a first sensor (30; 130) disposed within the housing, the first sensor configured to determine a concentration of carbon dioxide within an internal space (6) of a container (2); and a control system (40; 140) configured to receive input values from the first sensor and to provide an output when the concentration of carbon dioxide exceeds a predetermined value. The housing is substantially sealed for preventing the ingress of debris into the housing, and the housing is configured such that air is able to flow into the housing and over the first sensor.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: A method of forming an optical transmission flow cell that includes forming a fluid pathway cavity though a housing, and forming an optical pathway cavity through the housing and through the fluid pathway cavity, the optical pathway cavity configured to receive an optical fiber to emit light through the fluid pathway cavity. Material is added at a transition between the optical pathway cavity and fluid pathway cavity to form a surface at the transition configured to prevent formation of air pockets within fluid in the optical pathway cavity.

Abstract: A method of forming an optical transmission flow cell that includes forming a fluid pathway cavity though a housing, and forming an optical pathway cavity through the housing and through the fluid pathway cavity, the optical pathway cavity configured to receive an optical fiber to emit light through the fluid pathway cavity. Material is added at a transition between the optical pathway cavity and fluid pathway cavity to form a surface at the transition configured to prevent formation of air pockets within fluid in the optical pathway cavity.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: Apparatus and a method for collecting and redirecting liquid which has been separated from a gaseous process stream by inertial separation techniques such that the separated liquid and gaseous stream are flowing co-currently or counter-currently within the same process apparatus. The apparatus has liquid catch means, such as a flange, for catching the separated liquid and flow-through means, such as a flow-through opening in the flange, for simultaneously allowing the gaseous materials to flow, co-currently or counter-currently with the separated liquid, through and past the liquid catch means and downstream on to further processing equipment. The method comprises collecting the separate liquid phase by patching the separate liquid phase as it drips and flows down the inner wall of the process apparatus, while simultaneously allowing the gaseous materials to flow on, co-currently or counter-currently with the separate liquid phase, to further processing equipment, using the aforesaid apparatus.

Abstract: A method for component-based systems development includes one or more components with a preferably common database for storing business data. By using several steps or phases, the method includes identifying business processes and information of principal importance to the business, classifying the information, and utilizing component-based systems development to produce a deliverable set of software applications. The business data can be stored in the components and can be accessed and processed via an interactive electronic terminal such as a computer and application software. Legacy systems can be incorporated by the method such that existing data can be utilized for new applications.

Abstract: The invention provides a continuous process for producing a pure grade of acrylic acid having residual aldehyde levels under 10 parts per million. The process applies two groups of amines sequentially and continuously in selectively reducing acrolein and furfural and may be advantageously conducted in the presence of maleic acid and maleic anhydride impurities.