Patents by Inventor Timothy A. Mitsky

Timothy A. Mitsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8021866
    Abstract: The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: September 20, 2011
    Assignee: APT Therapeutics, Inc.
    Inventors: Soon Seog Jeong, Ridong Chen, Timothy A. Mitsky
  • Publication number: 20090035291
    Abstract: The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
    Type: Application
    Filed: June 24, 2008
    Publication date: February 5, 2009
    Inventors: Soon S. JEONG, Ridong Chen, Timothy A. Mitsky
  • Patent number: 7390485
    Abstract: The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: June 24, 2008
    Assignee: APT Therapeutics, Inc.
    Inventors: Soon S. Jeong, Ridong Chen, Timothy A. Mitsky
  • Publication number: 20080086787
    Abstract: The present invention is in the field of plant genetics and biochemistry. More specifically, the invention relates to genes associated with the tocopherol biosynthesis pathway. The present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with the genes of the tocopherol biosynthesis pathway. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express proteins associated with the tocopherol pathway. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.
    Type: Application
    Filed: July 3, 2007
    Publication date: April 10, 2008
    Inventors: Henry Valentin, Timothy Mitsky
  • Patent number: 7265207
    Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: September 4, 2007
    Assignee: Calgene LLC
    Inventors: Michael W. Lassner, Beth Savidge, Timothy A. Mitsky, James D. Weiss, Martha Ann Post-Beittenmiller
  • Patent number: 7247300
    Abstract: The present invention provides soluble forms of CD39L3 polypeptides and compositions, and methods useful inhibiting platelet activation and recruitment for the treatment and prevention of thrombotic disorders in mammals administered with soluble forms of CD39L3 polypeptides.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: July 24, 2007
    Assignee: APT Therapeutics, Inc.
    Inventors: Ridong Chen, Soon S. Jeong, Timothy A. Mitsky
  • Patent number: 7238855
    Abstract: The present invention is in the field of plant genetics and biochemistry. More specifically, the invention relates to genes associated with the tocopherol biosynthesis pathway. The present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with the genes of the tocopherol biosynthesis pathway. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express proteins associated with the tocopherol pathway. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: July 3, 2007
    Assignee: Monsanto Technology LLC
    Inventors: Henry E. Valentin, Timothy A. Mitsky, Ming Hao, Balasulojini Karunanandaa, Qungang Qi
  • Patent number: 7217865
    Abstract: The present invention provides transgenic plants transformed with an isolated DNA encoding a monomeric anthranilate synthase. The present invention also provides an isolated DNA encoding a monomeric anthranilate synthase from Agrobacterium tumefaciens. Transformation vectors and transformed plants containing the isolated DNA and seeds derived therefrom, are also provided.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: May 15, 2007
    Assignees: Monsanto Technology LLC, Renessen LLC
    Inventors: Lisa M Weaver, Jihong Liang, Ridong Chen, Soon Seog Jeong, Timothy Mitsky, Steven Slater, William Rapp
  • Patent number: 7192753
    Abstract: Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to ?-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: March 20, 2007
    Assignee: Monsanto Technology LLC
    Inventors: Kenneth J. Gruys, Timothy A. Mitsky, Ganesh M Kishore, Steven C. Slater, Stephen R. Padgette, David M. Stark
  • Patent number: 7141718
    Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: November 28, 2006
    Assignee: Calgene LLC
    Inventors: Michael W. Lassner, Timothy Mitsky, James Weiss, Martha Ann Post-Beittenmiller
  • Publication number: 20050289668
    Abstract: The present invention provides DNA constructs comprising exogenous polynucleotides encoding a threonine deaminase and/or AHAS. Transgenic plants transformed with the constructs, as well as seed and progeny dervied from these plants, are also provided. The transgenic plants have an increased level of one or more amino acids as compared to a non-transgenic plant of the same species.
    Type: Application
    Filed: May 6, 2004
    Publication date: December 29, 2005
    Inventors: Lisa Weaver, Timothy Mitsky, William Rapp, Kenneth Gruys, Jihong Liang, Gabriela Vaduva
  • Publication number: 20050268355
    Abstract: Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to ?-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.
    Type: Application
    Filed: June 28, 2005
    Publication date: December 1, 2005
    Inventors: Kenneth Gruys, Timothy Mitsky, Ganesh Kishore, Steven Slater, Stephen Padgette, David Stark
  • Publication number: 20050215505
    Abstract: The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
    Type: Application
    Filed: February 28, 2005
    Publication date: September 29, 2005
    Applicant: APT THERAPEUTICS, INC.
    Inventors: Soon Jeong, Ridong Chen, Timothy Mitsky
  • Patent number: 6946588
    Abstract: Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to ?-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: September 20, 2005
    Assignee: Monsanto Technology LLC
    Inventors: Kenneth J. Gruys, Timothy A. Mitsky, Ganesh M. Kishore, Steven C. Slater, Stephen R. Padgette, David M. Stark
  • Publication number: 20040018602
    Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
    Type: Application
    Filed: May 13, 2003
    Publication date: January 29, 2004
    Inventors: Michael W. Lassner, Beth Savidge, Timothy A. Mitsky, James D. Weiss, Martha Ann Post-Beittenmiller
  • Publication number: 20030182678
    Abstract: The use of multigene vectors for the preparation of transformed host cells and plants is disclosed. Multigene vectors reduce the number of transformations required, and leads to increased production of polyhydroxyalkanoate polymer in the resulting transformed host cells and plants.
    Type: Application
    Filed: August 8, 2002
    Publication date: September 25, 2003
    Applicant: Monsanto Technology LLC
    Inventors: Timothy A. Mitsky, Steven C. Slater, Steven E. Reiser, Ming Hao, Kathryn L. Houmiel
  • Publication number: 20030176675
    Abstract: The present invention is in the field of plant genetics and biochemistry. More specifically, the invention relates to genes associated with the tocopherol biosynthesis pathway. The present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with the genes of the tocopherol biosynthesis pathway. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express proteins associated with the tocopherol pathway. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.
    Type: Application
    Filed: May 3, 2002
    Publication date: September 18, 2003
    Inventors: Henry E. Valentin, Timothy A. Mitsky
  • Publication number: 20030170833
    Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
    Type: Application
    Filed: January 23, 2003
    Publication date: September 11, 2003
    Inventors: Michael W. Lassner, Beth Savidge, Timothy Mitsky, James D. Weiss, Martha Ann Post-Beittenmiller
  • Publication number: 20030097677
    Abstract: The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an isolated DNA segment encoding an anthranilate synthase in the cells of the plant. Transgenic plants transformed with an isolated DNA segment encoding an anthranilate synthase, as well as human or animal food, seeds and progeny derived from these plants, are also provided.
    Type: Application
    Filed: May 3, 2002
    Publication date: May 22, 2003
    Inventors: Lisa M. Weaver, Jihong Liang, Ridong Chen, Soon Seog Jeong, Timothy Mitsky, Steven Slater, William Rapp
  • Patent number: 6541259
    Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: April 1, 2003
    Assignee: Calgene LLC
    Inventors: Michael W. Lassner, Beth Savidge, Timothy Mitsky, James Weiss, Martha Ann Post-Beittenmiller