Patents by Inventor Timothy A. Stout
Timothy A. Stout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11098097Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.Type: GrantFiled: January 8, 2019Date of Patent: August 24, 2021Assignee: Research Development FoundationInventors: J. Timothy Stout, Binoy Appukuttan, Trevor McFarland
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Publication number: 20210024600Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.Type: ApplicationFiled: October 12, 2020Publication date: January 28, 2021Applicant: Research Development FoundationInventors: J. Timothy STOUT, Binoy APPUKUTTAN, Trevor McFARLAND
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Patent number: 10336797Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.Type: GrantFiled: November 22, 2010Date of Patent: July 2, 2019Assignee: Research Development FoundationInventors: J. Timothy Stout, Binoy Appukuttan, Trevor McFarland
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Publication number: 20190127430Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.Type: ApplicationFiled: January 8, 2019Publication date: May 2, 2019Applicant: Research Development FoundationInventors: J. Timothy STOUT, Binoy APPUKUTTAN, Trevor McFARLAND
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Patent number: 10070784Abstract: Disclosed herein are vitrectomy probes configured for use with optical coherence tomography.Type: GrantFiled: May 12, 2014Date of Patent: September 11, 2018Assignee: Oregon Health & Science UniversityInventors: David Huang, Yimin Wang, David Wilson, J. Timothy Stout, James Fujimoto, Chen Lu
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Patent number: 9937269Abstract: Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).Type: GrantFiled: December 5, 2016Date of Patent: April 10, 2018Assignee: Research Development FoundationInventors: J. Timothy Stout, Trevor J. McFarland, Binoy Appukuttan
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Publication number: 20170233444Abstract: Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24 to 47 of SEQ ID NO:15 and 2) each of SEQ ID NOs:16 and 17, but does not comprise the contiguous amino acids of SEQ ID NOs:8, 9, 11, or 12. Also disclosed are nucleic acids encoding the variant RTEF-1 polypeptides of the present invention. Pharmaceutical compositions that include the polypeptides and nucleic acids of the present invention are also disclosed. Methods of inducing cell contact inhibition, regulating organ size, and reducing intracellular YAP activity are also set forth, as well as methods of treating hyperproliferative diseases such as cancer using the pharmaceutical compositions of the present invention.Type: ApplicationFiled: May 2, 2017Publication date: August 17, 2017Applicants: Research Development Foundation, Oregon Health & Science UniversityInventors: J. Timothy STOUT, Binoy APPUKUTTAN, Trevor McFARLAND, Anna DYE
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Patent number: 9650426Abstract: Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24 to 47 of SEQ ID NO:15 and 2) each of SEQ ID NOs:16 and 17, but does not comprise the contiguous amino acids of SEQ ID NOs:8, 9, 11, or 12. Also disclosed are nucleic acids encoding the variant RTEF-1 polypeptides of the present invention. Pharmaceutical compositions that include the polypeptides and nucleic acids of the present invention are also disclosed. Methods of inducing cell contact inhibition, regulating organ size, and reducing intracellular YAP activity are also set forth, as well as methods of treating hyperproliferative diseases such as cancer using the pharmaceutical compositions of the present invention.Type: GrantFiled: June 9, 2014Date of Patent: May 16, 2017Assignees: Research Development Foundation, Oregon Health & Science UniversityInventors: J. Timothy Stout, Binoy Appukuttan, Trevor McFarland, Anna Dye
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Publication number: 20170081377Abstract: Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).Type: ApplicationFiled: December 5, 2016Publication date: March 23, 2017Applicant: Research Development FoundationInventors: J. Timothy STOUT, Trevor J. McFARLAND, Binoy APPUKUTTAN
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Patent number: 9512423Abstract: Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).Type: GrantFiled: May 5, 2014Date of Patent: December 6, 2016Assignee: Research Development FoundationInventors: J. Timothy Stout, Trevor J. McFarland, Binoy Appukuttan
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Publication number: 20160089025Abstract: Disclosed herein are vitrectomy probes configured for use with optical coherence tomography.Type: ApplicationFiled: May 12, 2014Publication date: March 31, 2016Inventors: David Huang, Yimin Wang, David Wilson, J. Timothy Stout, James Fujimoto, Chen Lu
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Patent number: 9222068Abstract: An apparatus for preparing multiple plant embryos for plant production includes a first station having a first rack system configured to support at least one incubation vessel, a second station having an automated member configured to manipulate the at least one incubation vessel and a third station having a second rack system configured to support the at least one incubation vessel after being manipulated by the automated member. The second station can be selectively adjusted to perform more than one operation required in the development of plant embryos.Type: GrantFiled: November 11, 2013Date of Patent: December 29, 2015Assignee: Arborgen, Inc.Inventors: Timothy Stout, John Clark, Sydney Seymour, Ronald Winkles
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Publication number: 20140357704Abstract: Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24 to 47 of SEQ ID NO:15 and 2) each of SEQ ID NOs:16 and 17, but does not comprise the contiguous amino acids of SEQ ID NOs:8, 9, 11, or 12. Also disclosed are nucleic acids encoding the variant RTEF-1 polypeptides of the present invention. Pharmaceutical compositions that include the polypeptides and nucleic acids of the present invention are also disclosed. Methods of inducing cell contact inhibition, regulating organ size, and reducing intracellular YAP activity are also set forth, as well as methods of treating hyperproliferative diseases such as cancer using the pharmaceutical compositions of the present invention.Type: ApplicationFiled: June 9, 2014Publication date: December 4, 2014Applicants: OREGON HEALTH & SCIENCE UNIVERSITY, RESEARCH DEVELOPMENT FOUNDATIONInventors: J. Timothy STOUT, Binoy APPUKUTTAN, Trevor MCFARLAND, Anna DYE
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Publication number: 20140322205Abstract: Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).Type: ApplicationFiled: May 5, 2014Publication date: October 30, 2014Applicant: RESEARCH DEVELOPMENT FOUNDATIONInventors: J. Timothy STOUT, Trevor J. MCFARLAND, Binoy APPUKUTTAN
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Patent number: 8785385Abstract: Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF promoter activity. Some of the RTEF-1 polypeptides include an amino acid sequence that is at least 80% identical to the contiguous amino acids of 1) amino acids 24 to 47 of SEQ ID NO:15 and 2) each of SEQ ID NOs:16 and 17, but does not comprise the contiguous amino acids of SEQ ID NOs:8, 9, 11, or 12. Also disclosed are nucleic acids encoding the variant RTEF-1 polypeptides of the present invention. Pharmaceutical compositions that include the polypeptides and nucleic acids of the present invention are also disclosed. Methods of inducing cell contact inhibition, regulating organ size, and reducing intracellular YAP activity are also set forth, as well as methods of treating hyperproliferative diseases such as cancer using the pharmaceutical compositions of the present invention.Type: GrantFiled: April 19, 2011Date of Patent: July 22, 2014Assignees: Research Development Foundation, Oregon Health & Science UniversityInventors: J. Timothy Stout, Binoy Appukuttan, Trevor McFarland, Anna Dye
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Patent number: 8748379Abstract: Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).Type: GrantFiled: June 6, 2008Date of Patent: June 10, 2014Assignee: Research Development FoundationInventors: J. Timothy Stout, Trevor J. McFarland, Binoy Appukuttan
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Publication number: 20140134664Abstract: An apparatus for preparing multiple plant embryos for plant production includes a first station having a first rack system configured to support at least one incubation vessel, a second station having an automated member configured to manipulate the at least one incubation vessel and a third station having a second rack system configured to support the at least one incubation vessel after being manipulated by the automated member. The second station can be selectively adjusted to perform more than one operation required in the development of plant embryos.Type: ApplicationFiled: November 11, 2013Publication date: May 15, 2014Applicant: ArborGen Inc.Inventors: Timothy STOUT, John CLARK, Sydney SEYMOUR, Ronald WINKLES
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Patent number: 8580566Abstract: An apparatus for preparing plant tissue (e.g., somatic embryos, embryogenic tissue, organogenic tissue, vegetative tissue, seeds, etc.) for plant production includes a first station having a first rack system configured to support at least one culture vessel, a second station having an automated member configured to manipulate the at least one culture vessel and a third station having a second rack system configured to support the at least one culture vessel after being manipulated by the automated member. The second station can be selectively adjusted to perform more than one operation required in the plant development. According to exemplary embodiments, the apparatus may include more than one second station (e.g., operational stations, etc.).Type: GrantFiled: September 23, 2008Date of Patent: November 12, 2013Assignee: Arborgen Inc.Inventors: Timothy Stout, John Clark, Sydney Symour, Ronald Winkles
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Patent number: 8414155Abstract: A luminaire having a plurality of LED boards mounted within a housing is provided. Each LED board has at least one light emitting diode mounted thereon and an axis extending from a first end of the board to a second end of the board. Each LED board is adjusted about its respective axis to an orientation that is unique from at least two other LED boards.Type: GrantFiled: March 18, 2009Date of Patent: April 9, 2013Assignee: Koninklijke Philips Electronics N.V.Inventors: Robert Catone, Charles S. Oldani, Robert F. Hammer, Timothy A. Stout, Robert Kloepple
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Patent number: 8376582Abstract: A luminaire having a plurality of LED boards mounted within a housing is provided. Each LED board has at least one light emitting diode mounted thereon and an axis extending from a first end of the board to a second end of the board. Each LED board is adjusted about its respective axis to an orientation that is unique from at least two other LED boards.Type: GrantFiled: March 26, 2010Date of Patent: February 19, 2013Assignee: Koninklijke Philips Electronics N.V.Inventors: Robert Catone, Charles S. Oldani, Robert F. Hammer, Timothy A. Stout, Robert Kloepple