Patents by Inventor Timothy A. Whitehead

Timothy A. Whitehead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190276884
    Abstract: The disclosure relates to methods for obtaining nucleic acid sequence information by constructing a nucleic acid library and reconstructing longer nucleic acid sequences by assembling a series of shorter nucleic acid sequences.
    Type: Application
    Filed: January 22, 2019
    Publication date: September 12, 2019
    Inventors: James A. STAPLETON, Timothy WHITEHEAD
  • Patent number: 10233490
    Abstract: The disclosure relates to methods for obtaining nucleic acid sequence information by constructing a nucleic acid library and reconstructing longer nucleic acid sequences by assembling a series of shorter nucleic acid sequences.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: March 19, 2019
    Assignee: Metabiotech Corporation
    Inventors: James A. Stapleton, Timothy Whitehead
  • Publication number: 20190062733
    Abstract: Deep mutational scanning is a foundational tool for addressing functional consequences of large numbers of mutants, yet a more efficient and accessible method for construction of user-defined mutagenesis libraries is needed. Provided herein are nicking saturation mutagenesis, a single-day, single-pot saturation mutagenesis method using routinely prepped plasmid dsDNA as input substrate. Reproducibility and convenience of the method are demonstrated through validation by an external research laboratory.
    Type: Application
    Filed: August 28, 2018
    Publication date: February 28, 2019
    Inventors: Justin Klesmith, James Stapleton, Timothy Whitehead, Emily Wrenbeck
  • Patent number: 9388217
    Abstract: Polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection are disclosed. Isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention are disclosed. Antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier are disclosed.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 12, 2016
    Assignee: University of Washington through its Center for Commercialization
    Inventors: David Baker, Timothy A. Whitehead, Sarel Fleishman
  • Publication number: 20160152972
    Abstract: The disclosure relates to methods for obtaining nucleic acid sequence information by constructing a nucleic acid library and reconstructing longer nucleic acid sequences by assembling a series of shorter nucleic acid sequences.
    Type: Application
    Filed: November 20, 2015
    Publication date: June 2, 2016
    Inventors: James A. Stapleton, Timothy Whitehead
  • Publication number: 20160024155
    Abstract: Polypeptides are disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection.
    Type: Application
    Filed: October 7, 2015
    Publication date: January 28, 2016
    Inventors: David BAKER, Timothy A. WHITEHEAD, Sarel FLEISHMAN
  • Patent number: 9181300
    Abstract: Polypeptides are disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: November 10, 2015
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: David Baker, Timothy A. Whitehead, Sarel Fleishman
  • Publication number: 20150038408
    Abstract: The present invention provides polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 12, 2013
    Publication date: February 5, 2015
    Inventors: David Baker, Timothy A. Whitehead, Sarel Fleishman
  • Publication number: 20140206628
    Abstract: Polypeptides are disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: David BAKER, Timothy A. WHITEHEAD, Sarel FLEISHMAN
  • Patent number: 8765686
    Abstract: Isolated polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection, or to diagnose or monitor progression of an influenza infection are described.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: July 1, 2014
    Assignee: University of Washington through its Center for Commercialization
    Inventors: David Baker, Timothy A. Whitehead, Sarel Fleishman
  • Patent number: 8685729
    Abstract: The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as ?-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: April 1, 2014
    Assignees: The Regents of the University of California, University of Maryland, Baltimore
    Inventors: Douglas S. Clark, Timothy Whitehead, Frank T. Robb, Pongpan Laksanalamai, Anchalee Jiemjit
  • Publication number: 20130143794
    Abstract: The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: August 3, 2011
    Publication date: June 6, 2013
    Applicant: University of Washington through its Center for Commercialization
    Inventors: David Baker, Timothy A. Whitehead, Sarel Fleishman
  • Publication number: 20110045554
    Abstract: The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as ?-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
    Type: Application
    Filed: February 26, 2008
    Publication date: February 24, 2011
    Applicants: The Regents of the University of California, University of Maryland, Baltimore
    Inventors: Douglas S. Clark, Timothy Whitehead, Frank T. Robb, Pongpan Laksanalamai, Anchalee Jiemjit
  • Patent number: 6865863
    Abstract: A palletizing mechanism (PP, WB, HB1-1, HB-2) supplies a pallet and a length of wrapping paper for receiving successive rows of bags until a full pallet load is prepared. The palletizing apparatus can be mated to the bagger apparatus, and operated synchronously therewith under the management of a common programmable controller. The palletizer apparatus receives each stick of can ends in a predetermined orientation, and maintains the orientation vis-a-vis all sticks in a pallet load. The sticks are placed sequentially into a row of predetermined number of sticks, then that row is loaded onto the top of a layer of wrapping, the first row being supported on a suitable empty pallet, then the wrap is passed over the last placed row. This operation proceeds with the wrap supply following a to-and-fromotion until the desired number of rows is automatically built up on a pallet.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: March 15, 2005
    Assignee: Dayton Systems Group, Inc.
    Inventors: Steven T. Cook, Brian W. Clark, Steffen W. Kracs, Dennis F. Moore, Jr., William E. Schneberger, Timothy A. Whitehead
  • Patent number: 6637178
    Abstract: An improved can end bagging system comprises four subassemblies: (1) the end gathering and stick assembly apparatus, (2) the bag feeding, opening, and loading apparatus which places a predetermined number of stacked can ends into an open end bag, (3) the vertical positioner apparatus for moving the bagged sticks into a folding device, and (4) the bag folding, closing and transfer apparatus. The loading mechanism includes a servo controlled pusher which is driven with controlled acceleration and deceleration to avoid tipping of the ends making up a stick, to avoid bursting of the bags during filling, and to assure complete and uniform filling of each bag. Sponginess which results primarily from variations in compression of the rims of the ends pressing against each other in the gathering and counting process is avoided.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: October 28, 2003
    Assignee: Dayton Systems Group, Inc.
    Inventors: Steven T. Cook, Brian W. Clark, Steffen W. Kracis, Dennis F. Moore, Jr., William E. Schneberger, Timothy A. Whitehead