Abstract: A delivery system includes a handle, a catheter shaft, and a steering mechanism. The catheter shaft extends from the handle to a flexible distal end portion. The steering mechanism is configured to steer the flexible distal end portion. The steering mechanism can include a steering element a control member, and one or more actuation elements. Actuating the control member can move the steering element to increase and/or decrease tension in one or more actuation elements.

Abstract: Devices for anchoring catheter systems, such as an atrioventricular heart valve regurgitation reduction system with a coapting element or spacer positioned within the atrioventricular valve leaflets. The spacer may be anchored above the atrioventricular valve with a rail that extends up into the subclavian vein, with tethers that attach to anchors around the annulus, or with a tether that connects to a stent expanded within an adjacent blood flow passage. The spacer may also be anchored below the atrioventricular valve with a rail that terminates in a tissue anchor within the ventricle, with tethers that attach to anchors around ventricle, or with a tether that connects to a stent expanded within an adjacent blood flow passage. The spacer may also be stabilized by a harness extending across the valve annulus or may be self-anchoring with an array of struts that extend into contact with the surrounding tissue.

Abstract: Devices and methods for securing a tissue anchor in tissue of a patient, in particular to ensure proper deployment of a cardiac tissue anchor by regulating the force or pressure of a deployment tool against the tissue. One way to ensure proper deployment force is to visualize the distal end of the tissue anchoring catheter from outside the body using a display for an imaging sensor, where the distal end of the catheter changes configuration when it is pressed against the tissue. Another method involves automatically regulating the pressure applied to the tissue prior to deployment of the tissue anchor, which may also be used in conjunction with visualization. Several safety locks to prevent deployment of the tissue anchor prior to establishment of the proper pressure are disclosed, which again may be used with visualization and/or an automated pressure regulator.

Abstract: A contaminant detector disposed within a base fluid for detecting the presence of a contaminating fluid includes a conductive core, a conductive sensor probe extending from the core in non-conductive relation, and a circuit board within the core. The circuit board is electrically connected to the sensor probe and electrically insulated from the core. Electrical power applied to the core creates a closed field loop for measuring the localized capacitance of the base fluid. When sufficient contaminating fluid exists in the base fluid to change the localized capacitance, an alarm is sounded to indicate the presence of the contaminating fluid.

Abstract: A contaminant detector disposed within a base fluid for detecting the presence of a contaminating fluid includes a conductive core, a conductive sensor probe extending from the core in non-conductive relation, and a circuit board within the core. The circuit board is electrically connected to the sensor probe and electrically insulated from the core. Electrical power applied to the core creates a closed field loop for measuring the localized capacitance of the base fluid. When sufficient contaminating fluid exists in the base fluid to change the localized capacitance, an alarm is sounded to indicate the presence of the contaminating fluid.