Patents by Inventor Timothy Andrew Riley

Timothy Andrew Riley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages
    Patent number: 6028188
    Abstract: Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: February 22, 2000
    Assignee: Genta Incorporated
    Inventors: Lyle John Arnold, Jr., Richard Isais Hogrefe, Mark Alan Reynolds, Timothy Andrew Riley, David Aaron Schwartz, Morteza Monir Vaghefi, Bob Dale Brown
  • Chirally enriched synthetic phosphate oligomers
    Patent number: 5955597
    Abstract: Oligomers having phosphonate internucleosidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: September 21, 1999
    Assignee: Genta, Incorporated
    Inventors: Lyle John Arnold, Jr., Mark Alan Reynolds, Timothy Andrew Riley, David Aaron Schwartz, Morteza Monir Vaghefi
  • Process for the purification of oligomers
    Patent number: 5811538
    Abstract: Methods for purifying an oligomer by normal phase column chromatography on a support selected from polyhydroxyethyl aspartamide, hydrophilic silica and silica from an oligomer impurity having a different nucleoside sequence are described. These methods are based upon the different retention times of the oligomer and the impurity on the column.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: September 22, 1998
    Assignee: Genta, Incorporated
    Inventors: Timothy Andrew Riley, Mark Alan Reynolds, Lloyd Robert Snyder, Robert E. Klem