Patents by Inventor Timothy B. C. Johnstone

Timothy B. C. Johnstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAreceptors
    Patent number: 8865719
    Abstract: The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: October 21, 2014
    Assignee: The Regents of the University of California
    Inventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS
    Publication number: 20120077816
    Abstract: The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
    Type: Application
    Filed: March 9, 2010
    Publication date: March 29, 2012
    Inventors: Timothy B.C. Johnstone, Dark J. Hogenkamp, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Patent number: 7825278
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: November 2, 2010
    Assignee: The Regents of the University of California
    Inventors: Derk J. Hogenkamp, Timothy B. C. Johnstone, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Patent number: 7820663
    Abstract: The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: October 26, 2010
    Assignee: The Regents of the University of California
    Inventors: Derk J. Hogenkamp, Timothy B. C. Johnstone, Kelvin W. Gee
  • Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof
    Publication number: 20080176897
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: February 15, 2008
    Publication date: July 24, 2008
    Inventors: Timothy B.C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
    Patent number: 7355047
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: April 8, 2008
    Assignee: The Regents of the University of California
    Inventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Publication number: 20080064748
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: May 5, 2005
    Publication date: March 13, 2008
    Inventors: Derk J. Hogenkamp, Timothy B.C. Johnstone, Kelvin W. Gee