Patents by Inventor Timothy B. Lowinger

Timothy B. Lowinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody drug conjugates comprising sting agonists
    Patent number: 12156870
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: December 3, 2024
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Jeremy R. Duvall, Keith W. Bentley, Raghida A. Bukhalid, Naniye Cetinbas, Marc I. Damelin, Eugene W. Kelleher, Timothy B. Lowinger, Joshua D. Thomas, Dorin Toader, Ling Xu, Liping Yang
  • PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES
    Publication number: 20240382611
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: March 6, 2024
    Publication date: November 21, 2024
    Inventors: Aleksandr V. YURKOVETSKIY, Natalya D. BODYAK, Bingfan DU, Dmitry R. GUMEROV, Mariya KOZYTSKA, Timothy B. LOWINGER, Cheri A. STEVENSON, Mao YIN
  • B7H4-TARGETED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20240269306
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Application
    Filed: March 5, 2024
    Publication date: August 15, 2024
    Inventors: Timothy B. LOWINGER, Chen-Ni CHIN, Marc I. DAMELIN, Dorin TOADER
  • SITE SPECIFIC ANTIBODY-DRUG CONJUGATES WITH PEPTIDE-CONTAINING LINKERS
    Publication number: 20240148887
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: August 30, 2023
    Publication date: May 9, 2024
    Inventors: Timothy B. LOWINGER, Marc I. Damelin, Dorin Toader
  • B7H4-targeted antibody-drug conjugates and methods of use thereof
    Patent number: 11964024
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Grant
    Filed: January 4, 2022
    Date of Patent: April 23, 2024
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Timothy B. Lowinger, Chen-Ni Chin, Marc I. Damelin, Dorin Toader
  • Peptide-containing linkers for antibody-drug conjugates
    Patent number: 11964025
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: April 23, 2024
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Aleksandr V. Yurkovetskiy, Natalya D. Bodyak, Bingfan Du, Dmitry R. Gumerov, Mariya Kozytska, Timothy B. Lowinger, Cheri A. Stevenson, Mao Yin
  • PROTEIN-POLYMER DRUG CONJUGATES
    Publication number: 20240082417
    Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
    Type: Application
    Filed: July 14, 2022
    Publication date: March 14, 2024
    Inventors: Roger A. Smith, Nitin K. Damle, Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Cheri A. Stevenson, Venu R. Gurijala
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS, COMBINATIONS AND METHODS OF USE
    Publication number: 20230398229
    Abstract: The present disclosure provides combinations comprising HER2-targeted STING agonist antibody-drug conjugates and HER2-targeted therapies or immunotherapies. The present disclosure also provides uses of the combinations in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: March 7, 2023
    Publication date: December 14, 2023
    Inventors: Raghida A. BUKHALID, Naniye Cetinbas, Marc I. Damelin, Timothy B. Lowinger, Dorin Toader
  • Site specific antibody-drug conjugates with peptide-containing linkers
    Patent number: 11786605
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: October 17, 2023
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Timothy B. Lowinger, Marc I. Damelin, Dorin Toader
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS
    Publication number: 20230321048
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: December 19, 2022
    Publication date: October 12, 2023
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • MONOCLONAL ANTIBODIES AGAINST HER2 EPITOPE AND METHODS OF USE THEREOF
    Publication number: 20230265197
    Abstract: This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.
    Type: Application
    Filed: October 26, 2022
    Publication date: August 24, 2023
    Inventors: Natalya D. BODYAK, Michael J. DEVIT, Eric M. KRAULAND, Timothy B. LOWINGER, Peter U. PARK, Bianka PRINZ, Aleksandr V. YURKOVETSKIY
  • PROTEIN-POLYMER-DRUG CONJUGATES
    Publication number: 20230183326
    Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
    Type: Application
    Filed: July 14, 2022
    Publication date: June 15, 2023
    Inventors: Roger A. Smith, Nitin K. Damle, Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Cheri A. Stevenson, Venu R. Gurijala
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS
    Publication number: 20230172910
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: December 20, 2022
    Publication date: June 8, 2023
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • Pyrrolobenzodiazepine antibody conjugates
    Patent number: 11638760
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: May 2, 2023
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Joshua D. Thomas, Brian D. Jones, Timothy B. Lowinger, Shuyi Tang, Mao Yin, Aleksandr V. Yurkovetskiy
  • PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES
    Publication number: 20230043447
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: August 12, 2021
    Publication date: February 9, 2023
    Inventors: Aleksandr V. YURKOVETSKIY, Natalya D. BODYAK, Bingfan DU, Dmitry R. GUMEROV, Mariya KOZYTSKA, Timothy B. LOWINGER, Cheri A. STEVENSON, Mao YIN
  • CYSTEINE ENGINEERED ANTIBODY-DRUG CONJUGATES WITH PEPTIDE-CONTAINING LINKERS
    Publication number: 20230021500
    Abstract: The present disclosure relates generally to cysteine engineered antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Application
    Filed: October 29, 2019
    Publication date: January 26, 2023
    Inventors: Dorin TOADER, Kalli CATCOTT, Timothy B. LOWINGER
  • Monoclonal antibodies against HER2 epitope and methods of use thereof
    Patent number: 11518812
    Abstract: This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: December 6, 2022
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Natalya D. Bodyak, Michael J. DeVit, Eric M. Krauland, Timothy B. Lowinger, Peter U. Park, Bianka Prinz, Aleksandr V. Yurkovetskiy
  • ANTIBODY DRUG CONJUGATES COMPRISING STING AGONISTS
    Publication number: 20220378749
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: April 2, 2021
    Publication date: December 1, 2022
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES
    Publication number: 20220305127
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.
    Type: Application
    Filed: December 21, 2018
    Publication date: September 29, 2022
    Inventors: Joshua D. THOMAS, Brian D. JONES, Eugene W. KELLEHER, Timothy B. LOWINGER, Liping YANG, Mao YIN, Aleksandr V. YURKOVETSKIY
  • PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES
    Publication number: 20220296725
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.
    Type: Application
    Filed: November 27, 2018
    Publication date: September 22, 2022
    Inventors: Joshua D. THOMAS, Brian D. JONES, Timothy B. LOWINGER, Shuyi TANG, Mao YIN, Aleksandr V. YURKOVETSKIY