Patents by Inventor Timothy B. Lowinger

Timothy B. Lowinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11638760
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: May 2, 2023
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Joshua D. Thomas, Brian D. Jones, Timothy B. Lowinger, Shuyi Tang, Mao Yin, Aleksandr V. Yurkovetskiy
  • Publication number: 20230043447
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: August 12, 2021
    Publication date: February 9, 2023
    Inventors: Aleksandr V. YURKOVETSKIY, Natalya D. BODYAK, Bingfan DU, Dmitry R. GUMEROV, Mariya KOZYTSKA, Timothy B. LOWINGER, Cheri A. STEVENSON, Mao YIN
  • Publication number: 20230021500
    Abstract: The present disclosure relates generally to cysteine engineered antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Application
    Filed: October 29, 2019
    Publication date: January 26, 2023
    Inventors: Dorin TOADER, Kalli CATCOTT, Timothy B. LOWINGER
  • Patent number: 11518812
    Abstract: This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: December 6, 2022
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Natalya D. Bodyak, Michael J. DeVit, Eric M. Krauland, Timothy B. Lowinger, Peter U. Park, Bianka Prinz, Aleksandr V. Yurkovetskiy
  • Publication number: 20220378749
    Abstract: The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.
    Type: Application
    Filed: April 2, 2021
    Publication date: December 1, 2022
    Inventors: Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
  • Publication number: 20220305127
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.
    Type: Application
    Filed: December 21, 2018
    Publication date: September 29, 2022
    Inventors: Joshua D. THOMAS, Brian D. JONES, Eugene W. KELLEHER, Timothy B. LOWINGER, Liping YANG, Mao YIN, Aleksandr V. YURKOVETSKIY
  • Publication number: 20220296725
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.
    Type: Application
    Filed: November 27, 2018
    Publication date: September 22, 2022
    Inventors: Joshua D. THOMAS, Brian D. JONES, Timothy B. LOWINGER, Shuyi TANG, Mao YIN, Aleksandr V. YURKOVETSKIY
  • Patent number: 11434278
    Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 6, 2022
    Assignee: Asana BioSciences, LLC
    Inventors: Roger A. Smith, Nitin K. Damle, Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Cheri A. Stevenson, Venu R. Gurijala
  • Publication number: 20220233707
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Application
    Filed: January 4, 2022
    Publication date: July 28, 2022
    Inventors: Timothy B. LOWINGER, Chen-Ni CHIN, Marc I. DAMELIN, Dorin TOADER
  • Patent number: 11135307
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: October 5, 2021
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Aleksandr V. Yurkovetskiy, Natalya D. Bodyak, Bingfan Du, Dmitry R. Gumerov, Mariya Kozytska, Timothy B. Lowinger, Cheri A. Stevenson, Mao Yin
  • Publication number: 20210301031
    Abstract: This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.
    Type: Application
    Filed: January 20, 2021
    Publication date: September 30, 2021
    Inventors: Donald A. BERGSTROM, Natalya D. BODYAK, Timothy B. LOWINGER, Peter U. PARK, Laura L. POLING, Aleksandr V. YURKOVETSKIY
  • Publication number: 20210220477
    Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.
    Type: Application
    Filed: January 8, 2021
    Publication date: July 22, 2021
    Inventors: Timothy B. LOWINGER, Marc I. DAMELIN, Dorin TOADER
  • Publication number: 20210106690
    Abstract: A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ?5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
    Type: Application
    Filed: January 23, 2020
    Publication date: April 15, 2021
    Inventors: Aleksandr V. YURKOVETSKIY, Mao YIN, Timothy B. LOWINGER, Joshua D. THOMAS, Charles E. HAMMOND, Cheri A. STEVENSON, Natalya D. BODYAK, Patrick R. CONLON, Dmitry R. GUMEROV
  • Patent number: 10947317
    Abstract: This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: March 16, 2021
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Donald A. Bergstrom, Natalya D. Bodyak, Timothy B. Lowinger, Peter U. Park, Laura L. Poling, Aleksandr V. Yurkovetskiy
  • Patent number: 10772971
    Abstract: The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: September 15, 2020
    Assignee: Mersana Therpeutics, Inc.
    Inventors: Venu Reddy Gurijala, Satyanarayan Reddy Bollu, Jacques Leblanc, Timothy B. Lowinger, Dennis McGillicuddy, Mao Yin, Aleksandr V. Yurkovetskiy
  • Patent number: 10660901
    Abstract: The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 26, 2020
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Mao Yin, Joshua D. Thomas, Aleksandr V. Yurkovetskiy, Patrick R. Conlon, Bingfan Du, Eugene W. Kelleher, Timothy B. Lowinger, Shuyi Tang
  • Patent number: 10603386
    Abstract: A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight?5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: March 31, 2020
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Charles E. Hammond, Cheri A. Stevenson, Natalya D. Bodyak, Patrick R. Conlon, Dmitry R. Gumerov
  • Publication number: 20200031941
    Abstract: This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.
    Type: Application
    Filed: October 2, 2019
    Publication date: January 30, 2020
    Inventors: Natalya D. BODYAK, Michael J. DeVIT, Eric M. KRAULAND, Timothy B. LOWINGER, Peter U. PARK, Bianka PRINZ, Aleksandr V. YURKOVETSKIY
  • Patent number: 10537645
    Abstract: Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently an Auristatin compound. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: January 21, 2020
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Charles E. Hammond, Cheri A. Stevenson, Natalya D. Bodyak, Patrick R. Conlon, Dmitry R. Gumerov
  • Patent number: 10526294
    Abstract: The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: January 7, 2020
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Joshua D. Thomas, Mao Yin, Aleksandr V. Yurkovetskiy, Patrick R. Conlon, Ahmed Hilmy, Eugene W. Kelleher, Timothy B. Lowinger, Cheri A. Stevenson, Shuyi Tang