Abstract: The present invention provides a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula (I) for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Abstract: The present invention provides a compound of Formula I. or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Abstract: Provided is a method of treating and/or preventing Wolfram Syndrome (WS)-related neurodegeneration (i.e. of Wolfram Syndrome-Associated Neuronal Degeneration), by increasing the expression and/or functional activity of p21. A method of screening for pharmacological agents useful in treating and/or preventing such conditions is also provided.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Abstract: The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Abstract: An intermediary access device enables a user electronic device to communicate with a vehicle's onboard computer system. A first wireless transceiver of the intermediary access device is used to establish a secure wireless communication channel between the intermediary access device and a vehicle on-board computer system. A second wireless transceiver of the intermediary access device is used to establish a user-initiated communication channel between the intermediary access device and a user electronic device. User commands and vehicle information can then be transmitted between the vehicle on-board computer system and the user electronic device via the intermediary access device in a safe, secure and efficient manner.

Abstract: 1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.

Abstract: 1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.

Abstract: The present invention provides compounds having the formula: wherein R1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.

Abstract: Provided is a method of treating and/or preventing Wolfram Syndrome (WS)-related neurodegeneration (i.e. of Wolfram Syndrome-Associated Neuronal Degeneration), by increasing the expression and/or functional activity of p21. A method of screening for pharmacological agents useful in treating and/or preventing such conditions is also provided.

Abstract: The present invention provides compounds having the formula: wherein R1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.

Abstract: An intermediary access device enables a user electronic device to communicate with a vehicle's onboard computer system. A first wireless transceiver of the intermediary access device is used to establish a secure wireless communication channel between the intermediary access device and a vehicle on-board computer system. A second wireless transceiver of the intermediary access device is used to establish a user-initiated communication channel between the intermediary access device and a user electronic device. User commands and vehicle information can then be transmitted between the vehicle on-board computer system and the user electronic device via the intermediary access device in a safe, secure and efficient manner.

Abstract: A steam autoclave (steam sterilization system) has a door for opening and closing an opening that defines the entrance to and exit from a steam sterilization chamber. The door may be latched and locked and pneumatically sealed when in a closed position. Preferably, the door has a convex portion that projects into the sterilization chamber when the door is in a closed position for aiding in providing an even distribution of steam throughout the sterilization chamber during operation of the steam autoclave.

Abstract: A steam autoclave for treating Regulated Medical Waste that uses a condensate drainage system that provides for condensate drainage while the steam autoclave chamber remains pressurized during the steam treatment cycle to create pressure variations in the autoclave which are used to initiate the introduction of repeated bursts of steam into the waste during the steam treatment cycle. The repeated bursts of steam into the autoclave during the steam treatment cycle agitates the steam and waste contained in the autoclave, thereby enhancing steam penetration into the waste being treated and thereby enhancing biological kill efficacy.

Abstract: A system and method for content exclusion from a multi-domain search, where search results are prioritized or potentially excluded based on content provided by a service provider. The system and method provide for providing access to a network by a primary service provider, the network including multiple sources of content; receiving at least one search parameter; performing a search for content based on the received at least one search parameter; prioritizing results of the search based on content provided by the primary service provider; and displaying the prioritized results. In one embodiment, the system and method further includes excluding at least one search result if the at least one search result matches content provided by the primary service provider.

Abstract: An apparatus for safely and conveniently placing and retrieving biological indicators and/or computerized data tracers from deep within loads of Regulated Medical/Infectious Waste comprises a rod with a cavity for holding the biological indicators and/or computerized data tracers. Preferably, the rod is tapered to a point on one end, has a handle on the opposite end, and has a cover to enclose the cavity. Additionally, it is preferred that the rod is fitted with a movable sealing ring of soft material for sealing the area where the rod penetrates the waste load.

Abstract: A steam autoclave has a main drain line and an auxiliary drain line through which condensate in the autoclave chamber is drained, the auxiliary drain line having a conduit extending therethrough defining a path for condensate to move through the auxiliary drain line, and at least a portion of the conduit having a cross-section sized to permit effective draining of condensate through the conduit while the autoclave chamber is pressurized without substantial loss of steam pressure in the autoclave chamber. A sensor may be positioned in the autoclave chamber for sensing a pressure drop during condensate draining while the autoclave chamber is pressurized and for initializing insertion of additional pressurized steam into the autoclave chamber as needed to maintain adequate steam pressure in the autoclave chamber.

Abstract: An apparatus for treating waste comprises a gravity drop steam heating tower for heating the waste to the biological kill temperature using pressurized steam, a first feed member for feeding the waste to be sterilized to the gravity drop steam heating tower, and a vaporization system. The vaporization system includes a heating chamber for facilitating vaporization of liquids in the waste, a conveying member for conveying the waste from the lower end portion of the gravity drop steam heating tower into and through the heating chamber, and a vaporization chamber for receiving the waste from the heating chamber and for releasing vapor entrained in the waste into the vaporization chamber.