Abstract: An assembly of a cup prosthesis (10) and instrument head is described. A cup prosthesis has a circumference and a central axis which defines axial and radial directions. An attachment member (8) is applied around the circumference of the cup. The attachment member comprises: a circumferential band (46); and at least two tabs (50) extending in an axial direction from the circumferential band and having a circumferential region of weakness (60). A surgical instrument head is attached to the attachment member and engaged with the cup prosthesis, and has a radial retaining element (38) which engages an outer radial face of the at least two tabs.

Abstract: A surgical instrument head for use with a cup prosthesis (10) is described. The cup prosthesis has an attachment member (8) applied around the circumference of the cup. The surgical instrument head is configured to engage the cup prosthesis and attach to the attachment member. The surgical instrument head includes a tab separation member (6) rotatable about a central axis of the instrument head relative to the instrument head and having a formation for engaging a rotation instrument (310). The tab separation member defines at least one radial cam surface (40) for engaging at least part of the attachment member in use. An assembly of the surgical instrument head and cup prosthesis and a tool (300) for operating the assembly are also described.

Abstract: The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.

Abstract: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.

Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify agents that alter Claudin polypeptide activities.

Abstract: There are disclosed novel polypeptides referred to as Pellino polypeptides, as well as fragments thereof, including immunogenic peptides. DNAs encoding such polypeptides as well as methods of using such DNAs and polypeptides are also disclosed.

Abstract: The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.

Abstract: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify agents that alter Claudin polypeptide activities.

Abstract: The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in phosphorylation reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, the use of such polypeptides in screening assays, and kits comprising these reagents.