Patents by Inventor Timothy BUGNI

Timothy BUGNI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Turbinmicin compounds, compositions and uses thereof
    Patent number: 12240859
    Abstract: Turbinmicin, an isolated compound of Formula (I) or IA is provided. Turbinomycin compounds of Formula (II) or (IIA) are also provided. A compound isolated from a bacterial species from the sea squirt, Ecteinascidia turbinate, and having a chemical formula of C34H29NO11 is also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: March 4, 2025
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Fan Zhang, Douglas R. Braun, David Andes, Miao Zhao
  • Biemamides and related scaffolds as inhibitors of transforming growth factor-beta signaling
    Patent number: 11618734
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: April 4, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • TURBINMICIN COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20220119402
    Abstract: Turbinmicin, an isolated compound of Formula (I) or IA is provided. Turbinomycin compounds of Formula (II) or (IIA) are also provided. A compound isolated from a bacterial species from the sea squirt, Ecteinascidia turbinate, and having a chemical formula of C34H29NO11 is also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed.
    Type: Application
    Filed: December 27, 2019
    Publication date: April 21, 2022
    Inventors: Timothy Bugni, Fan Zhang, Douglas R. Braun, David Andes, Miao Zhao
  • Forazolines, compositions thereof and uses thereof
    Patent number: 11135203
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 5, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun
  • BIEMAMIDES AND RELATED SCAFFOLDS AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA SIGNALING
    Publication number: 20210107879
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 15, 2021
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • Biemamides and related scaffolds as inhibitors of transforming growth factor-beta signaling
    Patent number: 10889551
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: January 12, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • BIEMAMIDES AND RELATED SCAFFOLDS AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA SIGNALING
    Publication number: 20200062715
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Application
    Filed: August 26, 2019
    Publication date: February 27, 2020
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20180243269
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20160243089
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • Forazolines, compositions thereof and uses thereof
    Patent number: 9346828
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: May 24, 2016
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20140364385
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 11, 2014
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN