Abstract: Various precursor solutions and methods of 3D printing and other additive manufacturing approaches are provided for the manufacture of articles using photocrosslinkable vinyl shape memory polymers. In various aspects, articles are manufactured by a process comprising (i) exposing a precursor solution to an intensity and frequency of light to initiate photo-polymerization of the precursor solution to form a layer of the article; and (ii) repeating step (i) a number of times to form the article in a layer-by-layer approach; wherein the precursor solution comprises a first polymeric precursor comprising a plurality of vinyl terminated side-chains attached thereto. A vinyl-functionalized, photocrosslinkable SMP used as an example herein is a novel variant of a previously disclosed SMP composition, with higher amounts of vinyl functionalization but similar thermomechanical properties to the SMP library previously disclosed.

Abstract: The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 400 ?m-1200 ?m and a pore spacing of about 100 ?m to about 750 ?m.

Abstract: The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 500-750 microns and a pore spacing of 220-250 microns.

Abstract: The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 500-750 microns and a pore spacing of 220-250 microns.

Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.

Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.

Abstract: Embodiments of the invention include polymeric compounds that comprise a co-polymer microgel at least one bioactive agent, pharmaceutical compounds comprising compounds of the present invention, and methods for treating damaged tissue to a patient in need thereof by administering by injection an effect amount of the composition.