Patents by Inventor Timothy C. Fisher
Timothy C. Fisher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9919074Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homo-polymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: GrantFiled: February 27, 2012Date of Patent: March 20, 2018Assignee: SYNCERA, INC.Inventors: Tadeusz Wellisz, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Patent number: 9616150Abstract: A method for controlling bleeding from bones, comprising the use of copolymers of oxyethylene and oxypropylene or mixtures thereof to cover the bleeding portions of bones. The copolymers are resorbable by the body, not metabolized, simple to prepare, inexpensive, readily available, and do not interfere with the fusion, osteogenesis, and related tissue healing and repair of the affected bones.Type: GrantFiled: April 29, 2002Date of Patent: April 11, 2017Assignee: CHILDREN'S HOSPITAL LOS ANGELESInventors: Michael Levy, Michael Y. Wang, Jonathan K. Armstrong, Timothy C. Fisher
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Patent number: 8455000Abstract: We describe the medical, dental, and surgical uses of modified poly(alkylene) materials which are fully resorbable after implantation into the body, and compositions formulated with such modified poly(alkylene) materials.Type: GrantFiled: May 22, 2007Date of Patent: June 4, 2013Assignee: Syncera Inc.Inventors: Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge, Tadeusz Z. Wellisz
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Publication number: 20120219497Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homo-polymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: ApplicationFiled: February 27, 2012Publication date: August 30, 2012Applicant: SYNCERA, INC.Inventors: Tadeusz WELLISZ, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Patent number: 8124687Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: GrantFiled: September 15, 2010Date of Patent: February 28, 2012Assignee: Syncera, Inc.Inventors: Tadeusz Wellisz, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Publication number: 20110002915Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: ApplicationFiled: September 15, 2010Publication date: January 6, 2011Applicant: SYNCERA, INCInventors: Tadeusz Z. Wellisz, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Publication number: 20110002974Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: ApplicationFiled: September 15, 2010Publication date: January 6, 2011Applicant: SYNCERA, INC.Inventors: Tadeusz Wellisz, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Patent number: 7829616Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: GrantFiled: June 8, 2009Date of Patent: November 9, 2010Assignee: Syncera, Inc.Inventors: Tadeusz Wellisz, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Publication number: 20090286886Abstract: We describe the medical, dental, and surgical uses of modified poly(alkylene) materials which are fully resorbable after implantation into the body, and compositions formulated with such modified poly(alkylene) materials.Type: ApplicationFiled: May 22, 2007Publication date: November 19, 2009Inventors: Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge, Tadeusz Z. Wellisz
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Publication number: 20090238758Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: ApplicationFiled: June 8, 2009Publication date: September 24, 2009Applicant: SYNCERA, INC.Inventors: Tadeusz WELLISZ, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Publication number: 20090191175Abstract: The present invention discloses methods and devices for selectively removing anti-PEG antibodies from a patient's blood prior to administration of a PEG-conjugated therapeutic agent so as to prevent immune reactions against the PEG-conjugated therapeutic agents when the agents are administered as a therapeutic regimen. Removal of anti-PEG antibodies may be physical, in which anti-PEG antibodies are physically removed from the blood through an extracorporeal blood circuit connected to an anti-PEG antibody removal device, or functional, in which an anti-PEG inactivating agent is infused into the patient's blood stream prior to administration of the PEG-conjugated therapeutic agent. Also disclosed is a device for selectively removing anti-PEG antibodies from a blood stream and system incorporating the device.Type: ApplicationFiled: February 20, 2009Publication date: July 30, 2009Applicant: University of Southern CaliforniaInventors: Jonathan K. ARMSTRONG, Timothy C. Fisher
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Patent number: 7553913Abstract: A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homo-polymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.Type: GrantFiled: February 12, 2004Date of Patent: June 30, 2009Assignee: Syncera, Inc.Inventors: Tadeusz Wellisz, Timothy C. Fisher, Jonathan K. Armstrong, John Cambridge
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Publication number: 20080145876Abstract: The present invention discloses an assay for determining the presence of an anti-PEG antibody in a biological sample. Embodiments according to this aspect of the present invention will generally have the steps of: (1) providing an antigen probe capable of forming an antibody-antigen complex with the anti-PEG antibody; (2) contacting the biological sample with the antigen probe under conditions favorable for formation of the antibody-antigen complex; and (3) analyzing the antigen probe, after having performed step (2), to detect for the presence of the antibody-antigen complex, wherein the presence of the anti-PEG antibody is determined if the antibody-antigen complex is detected. Also disclosed are methods for screening patients, methods for monitoring patients using assays of this invention and kits for performing thereof.Type: ApplicationFiled: November 20, 2007Publication date: June 19, 2008Applicant: University of Southern CaliforniaInventors: Jonathan K. Armstrong, Timothy C. Fisher
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Patent number: 6942859Abstract: Living cells modified at their surface with specially selected polymers are disclosed. A simple method to covalently attach specially selected PEG derivatives to the surface of RBC in aqueous media under mild conditions is a preferred example. The selected PEG-modification dramatically reduced aggregation and low shear viscosity of RBC resuspended in autologous plasma, and inhibited RBC agglutination by blood group-specific antibodies. The morphology and deformability of the PEG-treated cells were unaltered. The PEG coating of the RBC surface is applicable to the treatment of a variety of diseases characterized by vaso-occlusion or impaired blood flow, e.g., myocardial infarction, shock, and sickle cell disease.Type: GrantFiled: November 5, 2001Date of Patent: September 13, 2005Assignee: University of Southern CaliforniaInventors: Timothy C. Fisher, Jonathan K. Armstrong
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Publication number: 20030095945Abstract: A method for controlling bleeding from bones, comprising the use of copolymers of oxyethylene and oxypropylene or mixtures thereof to cover the bleeding portions of bones. The copolymers are resorbable by the body, not metabolized, simple to prepare, inexpensive, readily available, and do not interfere with the fusion, osteogenesis, and related tissue healing and repair of the affected bones.Type: ApplicationFiled: April 29, 2002Publication date: May 22, 2003Applicant: Children's Hospital Los AngelesInventors: Michael Levy, Michael Y. Wang, Jonathan K. Armstrong, Timothy C. Fisher
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Publication number: 20020141976Abstract: Living cells modified at their surface with specially selected polymers are disclosed. A simple method to covalently attach specially selected PEG derivatives to the surface of RBC in aqueous media under mild conditions is a preferred example. The selected PEG-modification dramatically reduced aggregation and low shear viscosity of RBC resuspended in autologous plasma, and inhibited RBC agglutination by blood group-specific antibodies. The morphology and deformability of the PEG-treated cells were unaltered. The PEG coating of the RBC surface is applicable to the treatment of a variety of diseases characterized by vaso-occlusion or impaired blood flow, e.g., myocardial infarction, shock, and sickle cell disease.Type: ApplicationFiled: November 5, 2001Publication date: October 3, 2002Applicant: The University of Southern CliforniaInventors: Timothy C. Fisher, Jonathan K. Armstrong
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Patent number: 6312685Abstract: Living cells are modified at their surface with specially selected polymers. Covalently attaching specially selected polyethylene glycol (PEG) derivatives to the surface of red blood cells (RBC) in aqueous media under mild conditions is a preferred example. The selected PEG derivatives dramatically reduced aggregation and low shear viscosity of RBC resuspended in autologous plasma, and inhibited RBC agglutination by blood group-specific antibodies. The morphology and deformability of the PEG-treated cells were unaltered. PEG coating of the RBC surface is applicable to the treatment of a variety of diseases characterized by vaso-occlusion or impaired blood flow, e.g., myocardial infarction, shock, and sickle cell disease. An infusion solution is prepared containing red blood cells covalently bound to a PEG derivative having a molecular weight of between 2,000 and 5,000 Daltons and a PEG derivative having a molecular weight between 10,000 and 35,000 Daltons.Type: GrantFiled: March 13, 1998Date of Patent: November 6, 2001Inventors: Timothy C. Fisher, Jonathan K. Armstrong
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Patent number: 5376878Abstract: An apparatus and method for counting and measuring the size of particles, particularly in the range 10 nanometers to 10 micrometers in diameter, and for measuring both the size and deformability of deformable particles, primarily red and white blood cells, in which are provided, in combination: --a membrane 10 containing multiple apertures 12 providing the only means of continuity between two fluid reservoirs 16 and 18; electrodes 20 and 22 mounted one in each reservoir; and another electrode 14 situated inside each aperture, forming part of the wall. The position of electrode 14 effectively divides the aperture into two aperture regions 28 and 30 having similar electrical resistance. In use, a conductive fluid containing the particles is placed into reservoir 16 and aspirated through the apertures into reservoir 18. A voltage V.sub.in applied between electrodes 20 and 22, causes a corresponding voltage V.sub.out at each electrode 14.Type: GrantFiled: September 27, 1993Date of Patent: December 27, 1994Inventor: Timothy C. Fisher