Patents by Inventor Timothy C. P. Van Asten

Timothy C. P. Van Asten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Determining Enzymatic Activity in Biological Media
    Publication number: 20120135436
    Abstract: A reliable, fast and convenient method is provided to determine the change in concentration of enzyme in time in a biological medium in the presence of a signal substrate that corrects for substrate consumption, color-dependency of the signal and non-linearity between the concentration of the leaving group of the signal substrate and the amount of signal. The method comprises the measurement of a calibrator curve in a suitable medium, such as a buffer, to determine the characteristics of the measured curve. These characteristics will then allow to obtain this whole curve or a sufficient part thereof again through a mathematical procedure based on a single-point measurement in a sample of a medium in which the enzyme generation takes place. This has the great advantage that there is no need to measure the whole calibrator curve in each individual medium, since a single-point measurement is adequate.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 31, 2012
    Inventors: Peter L.A. Giesen, Timothy C.P. Van Asten
  • Method for determining thrombin activity
    Patent number: 8133696
    Abstract: Methods and kits to determine thrombin activity are provided. They have the great advantage that there is no need to measure the whole calibrator curve in each individual medium, since a single-point measurement is adequate.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: March 13, 2012
    Assignee: Thrombinoscope B.V.
    Inventors: Peter L. A. Giesen, Timothy C. P. Van Asten
  • METHOD OF DETERMINING ENZYMATIC ACTIVITY IN BIOLOGICAL MEDIA
    Publication number: 20110020850
    Abstract: A reliable, fast and convenient method is provided to determine the change in concentration of enzyme in time in a biological medium in the presence of a signal substrate that corrects for substrate consumption, color-dependency of the signal and non-linearity between the concentration of the leaving group of the signal substrate and the amount of signal. The method comprises the measurement of a calibrator curve in a suitable medium, such as a buffer, to determine the characteristics of the measured curve. These characteristics will then allow to obtain this whole curve or a sufficient part thereof again through a mathematical procedure based on a single-point measurement in a sample of a medium in which the enzyme generation takes place. This has the great advantage that there is no need to measure the whole calibrator curve in each individual medium, since a single-point measurement is adequate.
    Type: Application
    Filed: June 6, 2007
    Publication date: January 27, 2011
    Inventors: Peter L.A. Giesen, Timothy C.P. Van Asten