Patents by Inventor Timothy C Thompson

Timothy C Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequences for targeting metastatic cells
    Patent number: 6252058
    Abstract: The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: June 26, 2001
    Inventor: Timothy C. Thompson
  • Use of &agr;1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia
    Patent number: 6177430
    Abstract: A method for reducing the extent of or preventing further hyperplasia in BPH in a mammal which comprises administering to said mammal an effective amount of a drug comprising an &agr;1-adrenoreceptor antagonist or pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: January 23, 2001
    Assignee: Pfizer Inc
    Inventors: Timothy C Thompson, Guang Yang, Michael G Wyllie
  • Use of .alpha..sub.1 -adrenoreceptor antagonists in the prevention and treatment of cancer
    Patent number: 5935962
    Abstract: A method for treating or preventing a cancer in a mammal which comprises administering to said mammal an amount of a drug, comprising an .alpha..sub.1 -adrenoreceptor antagonist or pharmaceutically acceptable acid addition salt thereof, effective for treating or preventing the cancer.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: August 10, 1999
    Assignee: Baylor College of Medicine and Pfizer, Inc.
    Inventors: Timothy C. Thompson, Guang Yang, Michael G. Wyllie
  • Method for identifying metastatic sequences
    Patent number: 5783182
    Abstract: The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells are implanted in an animal of a primary site and incubated for a period of time sufficient for the cells to proliferate and develop metastases at secondary sites. Expressed sequences from cells at the primary and secondary sites are amplified by differential display polymerase chain reaction and compared. Differentially expressed sequences are identical and can be cloned and sequenced. These sequences can be used as probes in the diagnosis of metastatic disorders, as probes to isolate metastatic sequences and as a therapeutic agent.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: July 21, 1998
    Assignee: Baylor College of Medicine
    Inventor: Timothy C. Thompson
  • Markers for invasive prostatic neoplasia
    Patent number: 5424192
    Abstract: This invention is directed to the identification, isolation and use of nonprostate derived markers, such as markers derived from the seminal vesicles, and antibodies which recognize these markers in the diagnosis of invasive proatic neoplasia, to diagnostic aids for screening biological samples for evidence of invasive prostatic neoplasia, and to methods for the use of these diagnostic aids.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: June 13, 1995
    Assignee: Baylor College of Medicine
    Inventors: Timothy C. Thompson, Thomas P. Dooley