Abstract: A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate with a solenoid actuation mechanism. Methods associated with use of the energy delivery probe are also covered.

Abstract: A system comprising a machine-readable storage medium storing at least one program and a computer-implemented method for collecting body measurements of a human user using a body measurement garment is provided. The body measurement garment comprises a plurality of sensors configured to produce a set of output data. The method may include receiving the set of output data from the body measurement garment and determining a plurality of body measurements from the output data. The method may further include generating a body shape model representing the shape of the body of the user. The method may also include generating a garment fit model representing the fit of a garment on the human user.

Abstract: High-voltage Schottky diodes are described. The diodes are capable of withstanding reverse-bias voltages of up to and in excess of 2000 V with reverse current leakage as low as 0.4 microamp/millimeter. In one example, a Schottky diode includes a conduction layer, a first layer over the conduction layer, a second layer over the first layer, a first cathode and a second cathode spaced apart and in electrical contact with the conduction layer, and an anode over the second layer between the first cathode and the second cathode. The first cathode and the second cathode can be electrically connected to each other as a cathode of the Schottky diode.

Abstract: Various aspects of Schottky diodes are described. The diodes are capable of withstanding reverse-bias voltages of up to and in excess of 2000 V with reverse current leakage as low as 0.4 microamp/millimeter in some cases among other aspects. In one example, a Schottky diode includes a conduction layer, a first layer over the conduction layer, a second layer over the first layer, a first cathode and a second cathode spaced apart and in electrical contact with the conduction layer, and an anode over the second layer between the first cathode and the second cathode. The first cathode and the second cathode can be electrically connected to each other as a cathode of the Schottky diode.

Abstract: In some aspects, a ground detection system may measure a difference from a tie point of the ungrounded electrical system and a ground point to determine if a grounded condition exists. The ground detection system may measure a plurality of signals at a plurality of distributed overload protection devices. The ground detection system may compare the plurality of signals from each of the plurality of distributed overload protection devices to stored threshold values. The ground detection system may determine a location of the grounded condition based at least in part on the comparing the plurality of signals from each of the plurality of distributed overload protection devices to the stored threshold values. In various embodiments, the location can be based on a length and an impedance of electrical circuit wiring. The ground detection system may display the location of the grounded condition on a display. Numerous other aspects are described.

Abstract: Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

Abstract: A system for molding an object includes an articulated mold having an axis and a plurality of mold portions configured to collectively define a molding cavity for shaping the object when arranged in respective molding positions. The system includes a plurality of actuators, each operatively coupled to a respective mold portion and configured to move the respective mold portion along the axis from the respective molding position toward a respective ejecting position for releasing the object. The system includes a controller in communication with each of the plurality of actuators and configured to independently activate each of the plurality of actuators such that one of the plurality of mold portions moves along the axis from the respective molding position toward the respective ejecting position while at least one other of the plurality of mold portions remains stationary relative to the object in order to at least partially support the object.

Abstract: Aspects of the present disclosure involve an apparatus, systems, and methods for providing intelligent laundering alerts. Example embodiments involve an intelligent garment tag that may be affixed to garments, and may store and provide information about the garment to which it is affixed. The information stored thereon describes various aspects of the garment including color, fabric, and laundering information. The intelligent garment tags further include an alert component for providing laundering alerts (e.g., a flashing or colored light, a warning noise, or a vibration) based on, for example, garment color compatibility or laundering device (e.g., washing machine or clothes dryer) compatibility.

Abstract: A system comprising a machine-readable storage medium storing at least one program and a computer-implemented method for collecting body measurements of a human user using a body measurement garment is provided. The body measurement garment comprises a plurality of sensors configured to produce a set of output data. The method may include receiving the set of output data from the body measurement garment and determining a plurality of body measurements from the output data. The method may further include generating a body shape model representing the shape of the body of the user. The method may also include generating a garment fit model representing the fit of a garment on the human user.

Abstract: A system for molding an object includes an articulated mold having an axis and a plurality of mold portions configured to collectively define a molding cavity for shaping the object when arranged in respective molding positions. The system includes a plurality of actuators, each operatively coupled to a respective mold portion and configured to move the respective mold portion along the axis from the respective molding position toward a respective ejecting position for releasing the object. The system includes a controller in communication with each of the plurality of actuators and configured to independently activate each of the plurality of actuators such that one of the plurality of mold portions moves along the axis from the respective molding position toward the respective ejecting position while at least one other of the plurality of mold portions remains stationary relative to the object in order to at least partially support the object.

Abstract: A system comprising a machine-readable storage medium storing at least one program and a computer-implemented method for collecting body measurements of a human user using a body measurement garment is provided. The body measurement garment comprises a plurality of sensors configured to produce a set of output data. The method may include receiving the set of output data from the body measurement garment and determining a plurality of body measurements from the output data. The method may further include generating a body shape model representing the shape of the body of the user. The method may also include generating a garment fit model representing the fit of a garment on the human user.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: Provided herein are methods, use, and compositions for treating systolic dysfunction such as heart failure with reduced ejection fraction.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: Aspects of the present disclosure involve an apparatus, systems, and methods for providing intelligent laundering alerts. Example embodiments involve an intelligent garment tag that may be affixed to garments, and may store and provide information about the garment to which it is affixed. The information stored thereon describes various aspects of the garment including color, fabric, and laundering information. The intelligent garment tags further include an alert component for providing laundering alerts (e.g., a flashing or colored light, a warning noise, or a vibration) based on, for example, garment color compatibility or laundering device (e.g., washing machine or clothes dryer) compatibility.

Abstract: Aspects of the present disclosure involve an apparatus, systems, and methods for providing intelligent laundering alerts. Example embodiments involve an intelligent garment tag that may be affixed to garments, and may store and provide information about the garment to which it is affixed. The information stored thereon describes various aspects of the garment including color, fabric, and laundering information. The intelligent garment tags further include an alert component for providing laundering alerts (e.g., a flashing or colored light, a warning noise, or a vibration) based on, for example, garment color compatibility or laundering device (e.g., washing machine or clothes dryer) compatibility.

Abstract: A system comprising a computer-readable storage medium storing at least one program and a computer-implemented method for simulating the fit of a particular garment on a user using a fit simulation garment. The fit simulation garment is wearable by a user and comprises a plurality of actuators configured to simulate tightness of regions of the particular garment. The method includes receiving a garment fit model defining the fit of the particular garment on the user. The method further includes parsing the garment fit model to generate control data for controlling the fit simulation garment, and transmitting the control data to the fit simulation garment to cause the plurality of actuators to collectively simulate the fit of the particular garment on the user.

Abstract: Described are a mold and molding process for manufacturing devices and containers that are scalable, modular, and lockable laterally and vertically with other like devices or containers. The mold is formed with a cup mold and top end mold sections specially designed to allow for molding and demolding a container with an undercut. The cup mold includes, on a vertical wall, one or more undercuts. Multiple undercuts may further form tongues with undercuts each of which forms a groove with undercuts on the molded article, and/or one or more grooves with undercuts each of which form a tongue with undercuts in the molded article. Molding and Demolding of the article with undercuts is further enabled by utilizing an improved method of molding said article with an undercut, and demolding said article from the mold once it is molded, by improvements to each stage of the molding process, including the preform stage, the conditioning station stage, the blow stage and the release stage.

Abstract: A system comprising a computer-readable storage medium storing at least one program and a computer-implemented method for simulating the fit of a particular garment on a user using a fit simulation garment. The fit simulation garment is wearable by a user and comprises a plurality of actuators configured to simulate tightness of regions of the particular garment. The method includes receiving a garment fit model defining the fit of the particular garment on the user. The method further includes parsing the garment fit model to generate control data for controlling the fit simulation garment, and transmitting the control data to the fit simulation garment to cause the plurality of actuators to collectively simulate the fit of the particular garment on the user.

Abstract: An actuator system for use in a mold system includes a first actuator operatively coupled to a first mold portion and configured to move the first mold portion along an axis in a first direction from a first molding position toward a first ejecting position. The system also includes a second actuator operatively coupled to a second mold portion and configured to move the second mold portion along the axis in the first direction from a second molding position toward a second ejecting position. The system further includes a controller in communication with the first and second actuators and configured to independently activate the first and second actuators.