Patents by Inventor Timothy Charlebois

Timothy Charlebois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Differential expression profiling analysis of cell culture phenotypes and the uses thereof
    Publication number: 20080070268
    Abstract: The present invention provides methods for systematically identifying genes and proteins and related pathways that maximize protein expression and secretion by expression profiling analysis. The present invention further provides methods for manipulating the identified genes and proteins to engineer improved cell lines.
    Type: Application
    Filed: April 21, 2007
    Publication date: March 20, 2008
    Applicants: Wyeth, Dublin City University
    Inventors: Karin Anderson, Niall Barron, Timothy Charlebois, Martin Clynes, Dana Di Nino, Padraig Doolan, Patrick Gammell, Kathleen Kopycinski, Mark Leonard, Kevin McCarthy, Paula Meleady, Mark Melville, Martin Sinacore
  • Methods for adapting mammalian cells
    Publication number: 20070231895
    Abstract: Methods of adapting cells, e.g., mammalian cells, to a cell culture process are provided. When the adapted cells are genetically modified and used for protein production, they exhibit beneficial characteristics, such as being able to attain higher cell densities and/or achieve a higher overall yield of the produced protein.
    Type: Application
    Filed: November 2, 2006
    Publication date: October 4, 2007
    Inventors: Gene Lee, D. Richards, Martin Sinacore, Mark Leonard, Timothy Charlebois, Mark Melville, Robin Heller-Harrison
  • Oligonucleotide arrays to monitor gene expression and methods for making and using same
    Publication number: 20060010513
    Abstract: The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype.
    Type: Application
    Filed: May 11, 2005
    Publication date: January 12, 2006
    Inventors: Mark Melville, Timothy Charlebois, William Mounts, Louane Hann, Martin Sinacore, Mark Leonard, Eugene Brown, Christopher Miller, Gene Lee
  • Novel polynucleotides related to oligonucleotide arrays to monitor gene expression
    Publication number: 20060003958
    Abstract: The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype.
    Type: Application
    Filed: May 11, 2005
    Publication date: January 5, 2006
    Inventors: Mark Melville, Timothy Charlebois, William Mounts, Louane Hann, Martin Sinacore, Mark Leonard, Eugene Brown, Christopher Miller, Gene Lee