Abstract: Disclosed herein include novel blood-brain barrier (BBB)-crossing receptors on the BBB interface, targeting peptides and derivatives thereof capable of binding to the novel receptors, and related methods of using the receptors to increase the permeability of the BBB and to deliver an agent to a nervous system (e.g., CNS). In some embodiments, the BBB-crossing receptor is LRP6. Disclosed herein also include recombinant adeno-associated viruses (rAAVs) with increased specificity and transduction efficiency across the BBB and related compositions and methods of treating various diseases and conditions.

Abstract: A miniaturized coupling for jewelry includes a male coupling and a female coupling, each of which is millimeter-sized or sub-millimeter-sized and each of which is attached to or suited to be attached to a respective jewelry component. The male coupling has a locking member configured to be inserted into the female coupling through an opening into an interior of the female coupling. A resiliently-biased, snap connector located in the interior of the female coupling, so constructed that when the locking member is inserted into the female coupling it initially moves and then is retained by the snap connector. An actuating pin in the female coupling is configured to move the snap connector to release the locking member and thereby disengage the male and female couplings from each other. The actuating pin has an outer surface accessible at an outer surface of the female coupling.

Abstract: This application relates to solid forms and salt forms of the PD-1/PD-L1 inhibitor 4,4?-(((((2,2?-dichloro-[1,1?-biphenyl]-3,3?-diyl)bis(azanediyl))bis(carbonyl))bis(1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-2,5-diyl))bis(ethane-2,1-diyl))bis(bicyclo[2.2.1]heptane-1-carboxylic acid), including processes of preparation thereof, where the solid forms and salt forms are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: Techniques are described herein for providing people suggestions in collaborative online text editors. A method includes: receiving user interface input that corresponds to a document in a document editing application; automatically parsing the received user interface input to identify a name included in the user interface input; in response to identifying the name included in the user interface input, providing an option to create a link in the document between the name and a corresponding contact in a contact store; receiving additional user interface input that indicates acceptance of the option to create the link in the document; and in response to receiving the additional user interface input, automatically creating the link in the document between the name and the corresponding contact in the contact store.

Abstract: A polyolefin and polyvinylpyrrolidone formulation including (A) an olefin-based (co)polymer, (B) a polyvinylpyrrolidone (co)polymer, and (C) an antioxidant. Also a method of making the composition; a crosslinked polyolefin product made by curing the composition; manufactured articles including a shaped form of the inventive formulation or product; and methods of using the inventive formulation, product, or articles.

Abstract: Isolating suspicious email links is described. An email security service receives an email that includes a link that refers to an external resource. A first suspicious link determination is performed to determine whether the link is suspicious. If the link is suspicious, the link is rewritten to refer to the email security and the email is delivered to the recipient. A request from a client device is received responsive to the link being opened. A second suspicious link determination is performed to determine whether the link is suspicious. If the link is suspicious, an interstitial page is transmitted to the client device that includes an option that, when selected, causes the first link to be opened in a remote browser isolation session.

Abstract: A monitoring circuit for a photovoltaic module includes a measurement conditioning circuit, a microcontroller circuit, and a transmitter circuit. The measurement conditioning circuit includes a voltage sense terminal, a voltage reference terminal, and a digital measurement data output. The microcontroller circuit includes a digital measurement data input coupled with the digital measurement data output, a modulation clock input, a measurement data stream output, and a transmit select output. The transmitter circuit includes a measurement data stream input coupled with the measurement data stream output, a modulation clock output coupled with the modulation clock input, a transmit select input coupled with the transmit select output, and positive and negative output communication terminals.

Abstract: A polyolefin-and-poly (2-alkyl-2-oxazoline) formulation comprising (A) an olefin-based (co) polymer, (B) a poly (2-alkyl-2-oxazoline) (co) polymer, and (C) an antioxidant. Also a method of making the composition; a crosslinked polyolefin product made by curing the composition; manufactured articles comprising a shaped form of the inventive formulation or product; and methods of using the inventive formulation, product, or articles.

Abstract: In an embodiment, a circuit includes: an error amplifier; a temperature sensor, wherein the temperature sensor is coupled to the error amplifier; a discrete time controller coupled to the error amplifier, wherein the discrete time controller comprises digital circuitry; a multiple bits quantizer coupled to the discrete time controller, wherein the multiple bits quantizer produces a digital code output; and a heating array coupled to the multiple bits quantizer, wherein the heating array is configured to generate heat based on the digital code output.

Abstract: A method for delivering a plurality of packages is described. The method includes obtaining, via a processor, information associated with a delivery plan of the plurality of packages from at least one memory. Based on the information, the method includes determining, via the processor, a current location, and a destination location of a target container. In response to the determination, the method includes determining, via the processor, a movement plan to move the target container to the destination location. Based on the movement plan, the method includes activating, via the processor, a first set of motorized tiles to move the target container to the destination location. The method further includes receiving, via the processor, an updated movement plan from a server plan when a preset condition is met. Based on the updated movement plan, the method includes activating, via the processor, a second set of motorized tiles.

Abstract: A computer-implemented method comprises creating and storing a plurality of different access group identifiers each associated with one or more user account identifiers, and a plurality of different classification markings each representing a different access restriction for an electronic document, and associating each of the user account identifiers with one or more of the classification markings; indexing each particular electronic document among a plurality of different electronic documents in association with values of one or more of the access group identifiers and with an inverse list of values of the classification markings that apply to the particular electronic document in a classification index; receiving a search query that specifies one or more attributes of electronic documents; obtaining one or more first classification markings, among the plurality of classification markings, which are associated with a particular user account identifier that is associated with the search query; executing a sea

Abstract: An example method may include obtaining operational instructions for operation of an autonomous tractor system to perform an agricultural task within an operational environment and directing the operational instructions to the autonomous tractor system. The method may also include while the autonomous tractor system is autonomously performing the agricultural task per the operational instructions, obtaining a notification that the autonomous tractor system is experiencing an unexpected event. The notification may provide an indication of the event and multiple responses performable by the autonomous tractor system in response to the event. In response to the notification, the method may include obtaining, based on input from a user, a selection of one of the multiple responses and directing the selected one of the multiple responses to the autonomous tractor system.

Abstract: A system comprises a computer having a processor and a memory, the memory storing instructions executable by the processor to access sensor data of a first sensor of a vehicle while an adaptive cruise control feature of the vehicle is active, detect, based on the sensor data of the first sensor, a stationary object located along a path of travel of the vehicle, wherein the stationary object is located outside of a range of a second sensor of the vehicle, determine a presence of an intersection within a threshold distance of the stationary object that is along the path of travel of the vehicle, and responsive to a determination that the stationary object is a stopped vehicle of the intersection, adjust, by the adaptive cruise control feature, the speed of the vehicle.

Abstract: The invention relates to Conditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: Techniques are described herein for providing people suggestions in collaborative online text editors. A method includes: receiving user interface input that corresponds to a document in a document editing application; automatically parsing the received user interface input to identify a name included in the user interface input; in response to identifying the name included in the user interface input, providing an option to create a link in the document between the name and a corresponding contact in a contact store; receiving additional user interface input that indicates acceptance of the option to create the link in the document; and in response to receiving the additional user interface input, automatically creating the link in the document between the name and the corresponding contact in the contact store.

Abstract: An electromagnetic relay includes a housing, an insulator, static terminals, and movable terminals. The housing has a top wall and a bottom opening that are opposite in a height direction, a front sidewall and a rear sidewall that are opposite in a front and rear direction, and a left sidewall and a right sidewall that are opposite in a left-right direction. The insulator is arranged in the housing and is formed with a plurality of chambers which are opened towards the front sidewall and are arranged in a row along the left-right direction. The insulator includes a partition plate located between two adjacent chambers. The static terminals are fixedly arranged in respective ones of the plurality of chambers. The movable terminals are arranged in respective ones of the plurality of chambers and are adapted to electrically contact the static terminals.

Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: In some implementations, a method includes receiving user input indicating a request to create a task and presenting a visual representation of the task. The method can also include receiving user input indicating an assignment of the task to an assignee, sending, to a second application, a first notification indicating the task and the assignment of the task to the assignee. It can further include receiving, from the second application, a second notification indicative of a change to a status of the task, and modifying the visual representation of the task to graphically illustrate the change in the status of the task in the user interface of the first application.

Abstract: Techniques are described herein for providing people suggestions in collaborative online text editors. A method includes: receiving user interface input that corresponds to a document in a document editing application; automatically parsing the received user interface input to identify a name included in the user interface input; in response to identifying the name included in the user interface input, providing an option to create a link in the document between the name and a corresponding contact in a contact store; receiving additional user interface input that indicates acceptance of the option to create the link in the document; and in response to receiving the additional user interface input, automatically creating the link in the document between the name and the corresponding contact in the contact store.

Abstract: A cardiac organoid containing 3-D matter of adult human heart tissue.