Patents by Inventor Timothy Claude Barden

Timothy Claude Barden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • sGC stimulators
    Patent number: 10183021
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 22, 2019
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi Nakai, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie
  • sGC STIMULATORS
    Publication number: 20180155345
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC1, RC2, Y, R9, o and W are as defined herein.
    Type: Application
    Filed: September 16, 2015
    Publication date: June 7, 2018
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Glen Robert RENNIE, Nicholas PERL, Ara MERMERIAN, Joon JUNG, James JIA, Rajesh R. IYENGAR, G-Yoon Jamie IM, Timothy Claude BARDEN, James Edward SHEPPECK, Paul Allan RENHOWE, Takashi NAKAI, Thomas Wai-Ho LEE, Karthik IYER
  • sGC STIMULATORS
    Publication number: 20180065971
    Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 8, 2018
    Inventors: Glen Robert Rennie, Rajesh R. Iyengar, Thomas Wai-Ho Lee, Takashi Nakai, Ara Mermerian, James Jia, G-Yoon Jamie Im, Paul Allan Renhowe, Joon Jung, Peter Germano, Karthik Iyer, Timothy Claude Barden, Kim Tang
  • PYRAZOLE DERIVATIVES AS SGC STIMULATORS
    Publication number: 20170291889
    Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 12, 2017
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Timothy Claude BARDEN, James Edward SHEPPECK, Glen Robert RENNIE, Paul Allan RENHOWE, Nicholas PERL, Takashi NAKAI, Ara MERMERIAN, Thomas Wai-Ho LEE, Joon JUNG, James JIA, Karthik IYER, Rajesh R. IYENGAR, G-Yoon Jamie IM
  • sGC STIMULATORS
    Publication number: 20170137439
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 18, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC STIMULATORS
    Publication number: 20170136019
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 18, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC stimulators
    Patent number: 9586937
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: March 7, 2017
    Assignee: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC STIMULATORS
    Publication number: 20160375022
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 29, 2016
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC STIMULATORS
    Publication number: 20160347738
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: July 21, 2016
    Publication date: December 1, 2016
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC stimulators
    Patent number: 9481689
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 1, 2016
    Assignee: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC STIMULATORS
    Publication number: 20160031903
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG
  • 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS
    Publication number: 20150342954
    Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: August 12, 2015
    Publication date: December 3, 2015
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Charles KIM, Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, G-Yoon Jamie IM, Timothy Claude BARDEN, Rajesh R. IYENGAR, Daniel P. ZIMMER, Angelika FRETZEN, Paul Allan RENHOWE
  • 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators
    Patent number: 9139564
    Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: September 22, 2015
    Assignee: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Charles Kim, Takashi Nakai, Joel Moore, Nicholas Robert Perl, G-yoon Jamie Im, Timothy Claude Barden, Rajesh R. Iyengar, Daniel P. Zimmer, Angelika Fretzen, Paul Allan Renhowe
  • NONOate derivatives and uses thereof
    Patent number: 9024069
    Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt of the compound. Also described are pharmaceutical formulations thereof and methods of using the same.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: May 5, 2015
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Jeffrey Segal, Nisha Perez, Timothy Claude Barden
  • 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS
    Publication number: 20150018353
    Abstract: Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: December 26, 2012
    Publication date: January 15, 2015
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Charles Kim, Takashi Nakai, Joel Moore, Nicholas Robert Perl, G-yoon Jamie Im, Timothy Claude Barden, Rajesh R. Iyengar, Daniel P. Zimmer, Angelika Fretzen, Paul Allan Renhowe
  • NONOATE DERIVATIVES AND USES THEREOF
    Publication number: 20140135295
    Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt of the compound. Also described are pharmaceutical formulations thereof and methods of using the same.
    Type: Application
    Filed: November 8, 2013
    Publication date: May 15, 2014
    Applicant: IRONWOOD PHARMACEUTICALS
    Inventors: Jeffrey Segal, Nisha Perez, Timothy Claude Barden
  • Process for the preparation of chiral isofluoroenes
    Patent number: 6770463
    Abstract: There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: August 3, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: John Francis Chiarello, Brian Lee Buckwalter, Timothy Claude Barden
  • Process for the preparation of chiral isofluoroenes
    Publication number: 20020032351
    Abstract: There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I.
    Type: Application
    Filed: August 2, 2001
    Publication date: March 14, 2002
    Applicant: BASF Aktiengesellschaft
    Inventors: John Francis Chiarello, Brian Lee Buckwalter, Timothy Claude Barden
  • Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds
    Patent number: 5973190
    Abstract: The present invention provides a process for the preparation of pesticidal fluoroolefin compounds having the structural formula I ##STR1## The present invention also provides intermediate compounds which are utilized in the process of this invention.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: October 26, 1999
    Assignee: American Cyanamid Company
    Inventors: Brian Lee Buckwalter, Timothy Claude Barden
  • 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
    Patent number: 5639742
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.1, R.sup.2 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: June 17, 1997
    Inventors: Ving Jick Lee, Brian Lee Buckwalter, Timothy Claude Barden