Patents by Inventor Timothy D. Cushing

Timothy D. Cushing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine derivatives
    Patent number: 6528513
    Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: March 4, 2003
    Assignee: Tularik INC
    Inventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
  • Antiinflammation agents
    Publication number: 20020161004
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
    Type: Application
    Filed: October 23, 2001
    Publication date: October 31, 2002
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Michelle F. Browner, David L. Clark, Timothy D. Cushing, Xiaolin Hao, Ronald C. Hawley, Xiao He, Juan C. Jaen, Sharada S. Labadie, Marie-Louise Smith, Francisco X. Talamas, Nigel P.C. Walker, Marc Labelle
  • Inhibitors of STAT function
    Patent number: 6426331
    Abstract: Compounds, compositions and methods that are useful in the treatment of immunoregulatory conditions and disorders are provided herein. In particular, the invention provides compounds which modulate the function of a Signal Transducer and Activator of Transcription (STAT) protein. The compounds are represented by the general formula: wherein Y, Ar, X, A2, A1, R1 and R2 are defined herein. The compounds are useful to treat, for example, allergic and inflammatory conditions and disorders.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: July 30, 2002
    Assignee: Tularik Inc.
    Inventors: Judi McKinney, Brian C. Raimundo, Timothy D. Cushing, Hiromitsu Yoshimura, Yutaka Ohuchi, Akira Hiratate, Hiroshi Fukushima
  • Template-directed interference footprinting of protein-adenine contacts
    Patent number: 6312897
    Abstract: A chemical analog of adenine is provided which can be incorporated into DNA but base pairs as normal, and does not disrupt DNA secondary structure. The analog is cleavable and disrupts functionality with DNA-binding protein. The analog finds use in a technique provided by the invention involving TDI footprinting or adenine-DNA contacts.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: November 6, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: Gregory L. Verdine, Timothy D. Cushing
  • PPARgamma modulators
    Publication number: 20010027200
    Abstract: Modulators of PPAR&ggr; activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
    Type: Application
    Filed: December 19, 2000
    Publication date: October 4, 2001
    Applicant: Tularik Inc.
    Inventors: Fabienne De la Brouse-Elwood, Jin-Long Chen, Timothy D. Cushing, John A. Flygare, Jonathan B. Houze, Juan C. Jaen, Lawrence R. McGee, Shi-Chang Miao, Steven Marc Rubenstein, Patrick C. Kearney
  • Pyrimidine derivatives
    Publication number: 20010018436
    Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
    Type: Application
    Filed: December 15, 2000
    Publication date: August 30, 2001
    Applicant: Tularik Inc.
    Inventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
  • Pyrimidine derivatives
    Patent number: 6200977
    Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 13, 2001
    Assignee: Tularik Inc.
    Inventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
  • PPAR-&ggr; modulators
    Patent number: 6200995
    Abstract: Modulators of PPAR&ggr; activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: March 13, 2001
    Assignee: Tularik Inc.
    Inventors: Fabienne De la Brouse-Elwood, Jin-Long Chen, Timothy D. Cushing, John A. Flygare, Jonathan B. Houze, Juan C. Jaen, Lawrence R. McGee, Shi-Chang Miao, Steven Marc Rubenstein, Patrick C. Kearney