Patents by Inventor Timothy D. Fitzpatrick

Timothy D. Fitzpatrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid forms comprising (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[B]azepine-4-carboxami compositions thereof, and uses thereof
    Patent number: 10604510
    Abstract: Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: March 31, 2020
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, Timothy D. Fitzpatrick, Anthony Frank, Ying Li, Xiaoling Lu, Marie G. Beauchamps, Antonio C. Ferretti
  • SOLID FORMS COMPRISING (1E, 4E)-2-AMINO-N,N-DIPROPYL-8-(4-(PYRROLIDINE-1-CARBONYL)PHENYL)-3H-BENZO[B]AZEPINE-4-CARBOXAMIDE, COMPOSITIONS THEREOF, AND USES THEREOF
    Publication number: 20200002316
    Abstract: Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 2, 2020
    Inventors: Hon-Wah MAN, Timothy D. FITZPATRICK, Anthony FRANK, Ying LI, Xiaoling LU, Marie G. BEAUCHAMPS, Antonio C. FERRETTI
  • SOLID FORMS COMPRISING (1E, 4E)-2-AMINO-N,N-DIPROPYL-8-(4-(PYRROLIDINE-1-CARBONYL)PHENYL)-3H-BENZO[B]AZEPINE-4-CARBOXAMIDE, COMPOSITIONS THEREOF, AND USES THEREOF
    Publication number: 20190100512
    Abstract: Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b] azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.
    Type: Application
    Filed: December 15, 2015
    Publication date: April 4, 2019
    Applicant: Celgene Corporation
    Inventors: Hon-Wah MAN, Timothy D. FITZPATRICK, Anthony FRANK, Ying LI, Xiaoling LU, Marie G. BEAUCHAMPS, Antonio C. FERRETTI
  • Bradykinin antagonist peptides incorporating N-substituted glycines
    Patent number: 5700779
    Abstract: The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin including pain and inflammation.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: December 23, 1997
    Assignee: Cortech, Inc.
    Inventors: Val S. Goodfellow, Manoj V. Marathe, Eric T. Whalley, Timothy D. Fitzpatrick, Karen G. Kuhlman
  • 6-position modified decapeptide LHRH antagonists
    Patent number: 5698522
    Abstract: The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A.sup.1 -D.sup.2 -E.sup.3 -G.sup.4 -J.sup.5 -L.sup.6 -M.sup.7 -Q.sup.8 -R.sup.9 -T.sup.10. The compounds of the percent invention are characterized by having an .OMEGA.-amino-functionalized side chain on the D-aminoacyl residue at position 6. The .OMEGA.-amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: December 16, 1997
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort, Jonathan Greer
  • N-terminus modified analogs of LHRH
    Patent number: 5502035
    Abstract: Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: March 26, 1996
    Assignee: Tap Holdings Inc.
    Inventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort
  • Process for producing peptides with side chains containing imidazolinylamino, tetrahydropyrimidinylamino, or alkylguanidinyl groups
    Patent number: 5432263
    Abstract: The present invention provides a process for the preparation of peptides which have or side-chains containing an alkyl- or dialkyl-substituted guanidinyl group or a imidazinylamino or tetrahydropyrimidinylamino group. The process provides higher overall yields of peptide product by permitting the synthesis of the entire peptide chain prior to modification of the side-chain to introduce the groups.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: July 11, 1995
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Rolf E. Swenson, Timothy D. Fitzpatrick
  • N-terminus modified analogs of LHRH
    Patent number: 5413990
    Abstract: Decapaptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: May 9, 1995
    Assignee: Tap Pharmaceuticals Inc.
    Inventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort
  • Octapeptide LHRH antagonists
    Patent number: 5140009
    Abstract: The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids, 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: August 18, 1992
    Assignee: Tap Pharmaceuticals, Inc.
    Inventors: Fortuna Haviv, Jonathan Greer, Christopher A. Palabrica, Timothy D. Fitzpatrick