Patents by Inventor Timothy D. Machajewski
Timothy D. Machajewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120225062Abstract: The present invention provides compounds of Formula I: and related compounds as further described herein, and pharmaceutical compositions comprising these compounds. The invention further provides methods to use these compounds and compositions for treating disorders associated with undesired levels of Pim kinase activity, including cancers and autoimmune disorders.Type: ApplicationFiled: March 2, 2012Publication date: September 6, 2012Inventors: Matthew Burger, Gisele Nishiguchi, Timothy D. Machajewski, Alice Rico, Robert Lowell Simmons, Aaron R. Smith, Victoriano Tamez, JR., Huw Tanner, Lifeng Wan
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Patent number: 7825132Abstract: Methods of inhibiting fibroblast growth factor receptor 3 and treating various conditions mediated by fibroblast growth factor receptor 3 are provided that include administering to a subject a compound of Structure I, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I have the following structure where and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting fibroblast growth factor receptor 3 and for use in treating conditions mediated by fibroblast growth factor receptor 3 such as multiple myeloma.Type: GrantFiled: November 5, 2004Date of Patent: November 2, 2010Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Shaopei Cai, Joyce Chou, Eric Harwood, Carla C. Heise, Timothy D. Machajewski, David Ryckman, Xiao Shang, Marion Wiesmann, Shuguang Zhu
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Publication number: 20100184754Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: ApplicationFiled: January 4, 2010Publication date: July 22, 2010Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, JR., Christopher McBride, Elisa Jazan
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Patent number: 7671059Abstract: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.Type: GrantFiled: September 28, 2006Date of Patent: March 2, 2010Assignee: Novartis AGInventors: Timothy D. Machajewski, Cynthia M. Shafer, Christopher McBride, William Antonios-McCrea, Brandon M. Doughan, Barry H. Levine, Yi Xia, Maureen McKenna, X. Michael Wang, Kris Mendenhall, Yasheen Zhou, Kristin Brinner, Zhenhai Gao, Daniel Poon, Paul Barsanti, Xiaodong Lin, Abran Costales, Alice Rico, Nathan Brammeier, Teresa Pick, Paul A. Renhowe
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Publication number: 20090281100Abstract: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.Type: ApplicationFiled: December 23, 2008Publication date: November 12, 2009Inventors: Paul A. Barsanti, Dirksen Bussiere, Stephen D. Harrison, Carla C. Heise, Johanna M. Jansen, Elisa Jazan, Timothy D. Machajewski, Christopher McBride, William R. McCrea, JR., Simon Ng, Zhi-Jie Ni, Sabina Pecchi, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Cynthia M. Shafer, Joel B. Silver, Allan S. Wagman, Marion Wiesmann, Kelly Wayman
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Patent number: 7598268Abstract: Organic compounds having the formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: GrantFiled: July 8, 2004Date of Patent: October 6, 2009Assignee: Novartis Vaccines & Diagnostics, Inc.Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan
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Patent number: 7470709Abstract: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.Type: GrantFiled: August 19, 2003Date of Patent: December 30, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Barsanti, Dirksen Bussiere, Stephen D. Harrison, Carla C. Heise, Johanna M. Jansen, Elisa Jazan, Timothy D. Machajewski, Christopher McBride, William R. McCrea, Jr., Simon Ng, Zhi-Jie Ni, Sabina Pecchi, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Cynthia M. Shafer, Joel B. Silver, Allan S. Wagman, Marion Wiesmann, Kelly Wayman
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Patent number: 7335774Abstract: A method for synthesizing a 4-amino substituted quinolinone includes reacting a substituted or unsubstituted 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile in the presence of a base or an acid. A 4-amino substituted quinolinone compound is formed by the reaction, and the 4-amino substituted quinolinone compound comprises a benzimidazole group.Type: GrantFiled: March 29, 2005Date of Patent: February 26, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Renhowe, Cynthia M. Shafer, Timothy D. Machajewski, Sabina Pecchi, Christopher McBride
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Patent number: 7064215Abstract: Organic compounds having the structure I are provided where the variables have the values described herein. Pharmaceutical formulations and medicaments include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compound or a pharmaceutically acceptable salt of the organic compound with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation or medicament according to the invention to a patient in need thereof.Type: GrantFiled: July 2, 2002Date of Patent: June 20, 2006Assignee: Chiron CorporationInventors: Paul A. Renhowe, Cynthia M. Shafer, Christopher McBride, Joel Benjamin Silver, Sabina Pecchi, Timothy D. Machajewski, William R. McCrea, Jr., Daniel J. Poon, Teresa Thomas
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Patent number: 6800760Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: GrantFiled: July 3, 2003Date of Patent: October 5, 2004Assignee: Chiron CorporationInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Elisa Jazan
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Patent number: 6774237Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: GrantFiled: October 30, 2002Date of Patent: August 10, 2004Assignee: Chiron CorporationInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Elisa Jazan
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Patent number: 6762194Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: GrantFiled: March 12, 2003Date of Patent: July 13, 2004Assignee: Chiron CorporationInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Eliza Jazan
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Patent number: 6756383Abstract: Organi c compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group in structures I and II. Pharmaceutical formulations include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: GrantFiled: August 30, 2001Date of Patent: June 29, 2004Assignee: Chiron CorporationInventors: Paul A. Renhowe, Timothy D. Machajewski, Cynthia M. Shafer, Mary Ellen Wernette Hammond, Sabina Pecchi
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Publication number: 20040097545Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.Type: ApplicationFiled: July 3, 2003Publication date: May 20, 2004Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan
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Publication number: 20040006101Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.Type: ApplicationFiled: March 12, 2003Publication date: January 8, 2004Applicant: CHIRON CORPORATIONInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Eliza Jazan
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Publication number: 20030207883Abstract: Organic compounds having the structure I are provided where the variables have the values described herein.Type: ApplicationFiled: July 2, 2002Publication date: November 6, 2003Applicant: Chiron CorporationInventors: Paul A. Renhowe, Cynthia M. Shafer, Christopher McBride, Joel Benjamin Silver, Sabina Pecchi, Timothy D. Machajewski, William R. McCrea, Daniel J. Poon, Teresa Thomas
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Publication number: 20030158224Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.Type: ApplicationFiled: October 30, 2002Publication date: August 21, 2003Applicant: Chiron CorporationInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea Jr, Christopher McBride, Elisa Jazan
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Patent number: 6605617Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.Type: GrantFiled: September 11, 2001Date of Patent: August 12, 2003Assignee: Chiron CorporationInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Elisa Jazan
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Publication number: 20030028018Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.Type: ApplicationFiled: April 5, 2002Publication date: February 6, 2003Applicant: Chiron CoporationInventors: Paul A. Renhowe, Sabina Pecchi, Timothy D Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan
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Publication number: 20020107392Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.Type: ApplicationFiled: September 11, 2001Publication date: August 8, 2002Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan