Abstract: Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.

Abstract: An injection device is disclosed comprising a plunger for expressing medicament from a syringe and a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe. A latch arrangement is provided that releasably holds the plunger against the force of the delivery mechanism. The latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position. A trigger is provided for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger. A method of manufacturing the injection device is also enclosed.

Abstract: The present invention provides processes for the preparation of a hydrochloric acid salt of compound of formula (2): wherein: R1 is selected from the group consisting of —H, an unsubstituted straight-chain C1-C20-alkyl, substituted straight-chain C1-C20-alkyl, unsubstituted branched-chain C1-C20-alkyl, substituted branched-chain C1-C20-alkyl, unsubstituted cyclic C3-C20-alkyl, and substituted cyclic C3-C20-alkyl; and R2 is selected from the group consisting of an unsubstituted straight-chain C1-C20-alkyl, substituted straight-chain C1-C20-alkyl, unsubstituted branched-chain C1-C20-alkyl, substituted branched-chain C1-C20-alkyl, unsubstituted cyclic C3-C20-alkyl, substituted cyclic C3-C20-alkyl, unsubstituted —C1-20-alkyl-C3-20-cycloalkyl, substituted —C1-20-alkyl-C3-20-cycloalkyl, unsubstituted allyl and substituted allyl.

Abstract: A method of controlling a heating element for providing heat to a catalyst of a catalytic converter, the method comprising: determining a catalyst performance characteristic as a function of time, and varying the amount of heating provided by the heating element in response to a change in the catalyst performance characteristic being greater than a predetermined amount.

Abstract: A process for culturing Clostridium saccharoperbutylacetonicum cells, which are capable of growing on gamma-cyclodextrin in a liquid culture medium in a culture vessel. Also disclosed is a process for producing a bio-product, the process comprising culturing Clostridium saccharoperbutylacetonicum cells, which are capable of growing on gamma-cyclodextrin in a liquid culture medium in a culture vessel.

Abstract: The subject matter of the disclosure relates to a method of diagnosing NOx storage catalyst during the operation of a motor vehicle. The method uses two diagnosis sub-methods having various sensitivities with respect to sulfur contamination of the NOx storage catalyst. The results of the two sub-methods are used to ascertain proportions of aging of the NOx storage catalyst resulting from thermal aging and sulfur contamination.

Abstract: The present invention provides processes for preparing morphinan-6-one compounds, in particular oxymorphone and salts thereof, having improved impurity profiles.

Abstract: The subject matter of the disclosure relates to a method of diagnosing NOx storage catalyst during the operation of a motor vehicle. The method uses two diagnosis sub-methods having various sensitivities with respect to sulfur contamination of the NOx storage catalyst. The results of the two sub-methods are used to ascertain proportions of aging of the NOx storage catalyst resulting from thermal aging and sulfur contamination.

Abstract: A process for preparing a compound of formula (3), includes the steps of: (a) providing an aqueous acidic solution including a compound of formula (1) and, as an impurity, a compound of formula (2); and (b) treating the aqueous acidic solution of step (a) such that the compound of formula (2) dehydrates to form a compound of formula (1) which is reduced to form an aqueous acidic solution of the compound of formula (3), the treating step (b) being carried out at one or more temperatures greater than ambient in the presence of a hydrogenation catalyst and hydrogen gas; and wherein for the compounds of formulae (1), (2) and (3): i) R1 is —OH, R2 is —OH and R3—H; or ii) R1 is —OCH3, R2 is —H and R3—CH3; or iii) R1 is —OH, R2 is —H and R3—CH3; or iv) R1 is —OCH3, R2 is —H and R3—H; or v) R1 is —OH, R2 is —H and R3—H; or vi) R1 is —OCH3, R2 is —OH and R3—H.

Abstract: A method of repairing a defect in a skin of an aircraft wing made from a composite material is disclosed. The wing has a stringer attached to an inner surface of the skin and the method comprises the steps of: cutting a section of stringer from the skin in the vicinity of the defect; positioning a repair plate on the inner surface over the defect so that it extends between opposing cut ends of the stringer; positioning a stringer repair part on the repair plate, the stringer repair part being of a length sufficient to overlap each cut end of the stringer; attaching the repair plate to the skin; and, attaching the stringer repair part to the stringer in a region of overlap at each cut end. Apparatus for repairing a wing is also disclosed.

Abstract: The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6?-oxycodol in an amount ?about 0.800 area % as determined by HPLC.

Abstract: The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6?-oxycodol in an amount ?about 0.800 area % as determined by HPLC.

Abstract: Systems and methods are disclosed for improving the resolution and quality of an image formed by signals from an array of receivers. Multiple receivers introduce variations in arrival times that can be less than the period of an operating signal, and also less than the period associated with a sampling operation. Thus, multiple receivers allow sampling of fine features of reflected signals that would be considered beyond the resolution associated with the operating signal. Use of multiple receivers also provides an effective sampling rate that is greater than the sampling rate of an individual receiver. Similar advantages can be obtained using multiple transmitters. Such advantageous features can be used to obtain high resolution images of objects in a medium in applications such as ultrasound imaging. Sub-Nyquist sampling is discussed. Accounting for the effects of refraction on pathlengths as a signal passes between two regions of different sound speed allows improved calculation of focus distances.

Abstract: Systems and methods are disclosed for improving the resolution and quality of an image formed by signals from an array of receivers. Multiple receivers introduce variations in arrival times that can be less than the period of an operating signal, and also less than the period associated with a sampling operation. Thus, multiple receivers allow sampling of fine features of reflected signals that would be considered beyond the resolution associated with the operating signal. Use of multiple receivers also provides an effective sampling rate that is greater than the sampling rate of an individual receiver. Similar advantages can be obtained using multiple transmitters. Such advantageous features can be used to obtain high resolution images of objects in a medium in applications such as ultrasound imaging. Sub-Nyquist sampling is discussed.

Abstract: Systems and methods are disclosed for improving the resolution and quality of an image formed by signals from an array of receivers. Multiple receivers introduce variations in arrival times that can be less than the period of an operating signal, and also less than the period associated with a sampling operation. Thus, multiple receivers allow sampling of fine features of reflected signals that would be considered beyond the resolution associated with the operating signal. Use of multiple receivers also provides an effective sampling rate that is greater than the sampling rate of an individual receiver. Similar advantages can be obtained using multiple transmitters. Such advantageous features can be used to obtain high resolution images of objects in a medium in applications such as ultrasound imaging.

Abstract: An active window seal assembly is disclosed that operatively engages a movable window when the window is stationary and disengages the window when the window is in motion. The seal assembly comprises a stationary frame, a movable lip that is operatively connected to the stationary frame, and a cavity disposed between the stationary frame and the movable lip. Several configurations provide for movement of the movable lip when the movable window is in motion. The first configuration allows the cavity to inflate with air, thus forcing the movable lip away from the window. A second configuration provides that the air in the cavity be evacuated, thus pulling the movable lip away from the window. A third configuration provides that a voltage be applied to the stationary frame and the movable lip to create an electric field. The electric field draws the movable lip toward the stationary frame and away from the movable window.

Abstract: A tracheal humidification system (20) includes a filter (26) for humidifying the air being breathed by the patient. The filter (26) is disposed in an uppermost portion (24) of a breathing path (22). At least one secretion path (28) including a drain tube (30) is provided for collecting secretions (512) from the patient. Filter (26) is disposed above the secretion path (28), so that the secretions (512) are prevented from contacting and clogging filter (26).

Abstract: An object detection system includes a sensor in communication with a controller which identifies contact with the sensor. In a preferred embodiment the sensor is a piezo film which generates a signal when an object applies a predetermined force to the edge of the moveable glass member. This signal is identifiable by the controller in communication with the piezo film. Another embodiment of the sensor provides a pair of substantially parallel segments of conductive material applied along the edge of the window. When an object is in contact with both segments of conductive material an electrical signal is conducted and identified by the controller. When the controller determines an object is in contact with the sensor and therefore the moveable glass member, the controller halts or reverses the movement of the moveable glass member to prevent trapping the object between the closing moveable glass member and the frame.

Abstract: A method and system for detecting the presence of an object caught between an automotive window and its respective frame includes a sensor mounted on a drive motor that drives a regulator to move the window upward and downward. The sensor senses a resistive torque applied against the regulator and generates a signal having a value proportional to the amount of resistive torque sensed. The signal is transmitted to a control circuit which then determines whether or not an object is caught between the window and its respective frame.

Abstract: A method and system for detecting the presence of an object caught between an automotive window and its respective frame includes an electric drive motor for opening and closing the automotive window. The electric drive motor receives power from a power supply via a primary brush assembly coupled to a power line. A piezoelectric sensor is mounted on the drive motor for sensing a resistive torque applied to the regulator and generating a signal having a value indicative of the resistive torque. The signal is then transmitted to a control circuit for determining whether or not an object is caught between the window and a frame based on the signal. The signal may be transmitted to the control circuit either by the primary brush assembly via the power line or by a secondary brush assembly coupled directly to the control circuit.