Patents by Inventor Timothy Donald Neubert

Timothy Donald Neubert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted tetrahydrofurans as modulators of sodium channels
    Patent number: 11919887
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Grant
    Filed: November 8, 2022
    Date of Patent: March 5, 2024
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Steven John Durrant, Nadia M. Ahmad, Elizabeth Mary Beck, Lidio Marx Carvalho Meireles, Ewa Iwona Chudyk, Gorka Etxebarria Jardi, Bhairavi Galan, Sara S. Hadida Ruah, Dennis James Hurley, Ronald Marcellus Knegtel, Timothy Donald Neubert, Joanne Louise Pinder, Joseph Pontillo, Robert Pullin, Yvonne Schmidt, David Matthew Shaw, Sarah Skerratt, Dean Stamos, Stephen Andrew Thomson, Anisa Nizarali Virani, Christopher Wray
  • Substituted tetrahydrofurans as modulators of sodium channels
    Patent number: 11834441
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: December 5, 2023
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Steven John Durrant, Nadia Ahmad, Elizabeth Mary Beck, Lidio Marx Carvalho Meireles, Ewa Iwona Chudyk, Gorka Etxebarria Jardi, Bhairavi Galan, Sara S. Hadida Ruah, Dennis James Hurley, Ronald Marcellus Knegtel, Timothy Donald Neubert, Joanne Louise Pinder, Joseph Pontillo, Robert Pullin, Yvonne Schmidt, David Matthew Shaw, Sarah Skerratt, Dean Stamos, Stephen Andrew Thomson, Anisa Nizarali Virani, Christopher Wray
  • HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN
    Publication number: 20230382910
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: April 21, 2023
    Publication date: November 30, 2023
    Inventors: Mark Thomas Miller, Dennis James Hurley, Timothy Donald Neubert, Elamprakash Nesan Savariar, Urvi Patel, Sara Sabina Hadida Ruah, Jason McCartney, Jinglan Zhou, Robert Martin Demoret, Roman Askatovich Valiulin, Alexander Frederik Kintzer, Peter Webb, David Robert Slochower, Kathleen Aertgeerts, Elizabeth Mary Beck, Ronald Marcellus Alphonsus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder
  • N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
    Patent number: 11827627
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: November 28, 2023
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Elizabeth Mary Beck, Steven John Durrant, Sarah Skerratt, Robert Pullin, Gorka Etxebarria Jardi, David Matthew Shaw, Nadia M. Ahmad, Christopher Wray, Anisa Nizarali Virani, Kiri North, James Dodd, Michael Edward O'Donnell, Bhairavi Galan, Ronald Marcellus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder, Stephen Andrew Thomson, Lidio Marx Carvalho Meireles, Dean Stamos, Yvonne Schmidt, Joseph Pontillo, Sara S. Hadida Ruah, Timothy Donald Neubert, Dennis James Hurley, Jinglan Zhou
  • HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN
    Publication number: 20230373925
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: April 21, 2023
    Publication date: November 23, 2023
    Inventors: Mark Thomas Miller, Dennis James Hurley, Timothy Donald Neubert, Vijayalaksmi Arumugam, Sara Sabina Hadida Ruah, Jason McCartney, Jinglan ZHOU, Jaclyn Chau, Robert Martin Demoret, Senait G. Ghirmai, Roman Askatovich Valiulin, Alexander Frederik Kintzer, David Robert Slochower, Kathleen Aertgeerts, Elizabeth Mary Beck, James Jun Bon Mui, Miranda Adele Wright, Ronald Marcellus Alphonsus Knegtel, Ewa Iwona Chudyk, Joanne Louise Pinder, James Dodd
  • SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS
    Publication number: 20230286961
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: November 8, 2022
    Publication date: September 14, 2023
    Inventors: Steven John Durrant, Nadia M. Ahmad, Elizabeth Mary Beck, Lidio Marx Carvalho Meireles, Ewa Iwona Chudyk, Gorka Etxebarria Jardi, Bhairavi Galan, Sara S. Hadida Ruah, Dennis James Hurley, Ronald Marcellus Knegtel, Timothy Donald Neubert, Joanne Louise Pinder, Joseph Pontillo, Robert Pullin, Yvonne Schmidt, David Matthew Shaw, Sarah Skerratt, Dean Stamos, Stephen Andrew Thomson, Anisa Nizarali Virani, Christopher Wray
  • Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels
    Patent number: 8841282
    Abstract: The present invention relates to pyrrolidinone benzenesulfonamides of the following formula: useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: September 23, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Stamos, Esther Ann Martinborough, Nicole Hilgraf, Timothy Donald Neubert, Mehdi Numa, Tara Whitney, Aarti Sameer Kawatkar
  • Pyrrolidinone Benzenesulfonamide Derivatives as Modulators of Ion Channels
    Publication number: 20130338119
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: August 15, 2013
    Publication date: December 19, 2013
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Stamos, Esther Ann Martinborough, Nicole Hilgraf, Timothy Donald Neubert, Mehdi Numa, Tara Whitney, Aarti Sameer Kawatkar
  • Bicyclic derivatives as modulators of voltage gated ion channels
    Patent number: 8492403
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: July 23, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Aarti Sameer Kawatkar, Esther Ann Martinborough, Nicole Hilgraf, Andreas P. Termin, Timothy Donald Neubert
  • Piperidine and Piperazine Phenyl Sulfonamides as Modulators of Ion Channels
    Publication number: 20130035310
    Abstract: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Application
    Filed: October 2, 2012
    Publication date: February 7, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Esther Ann Martinborough, Lev Tyler Dewey Fanning, Urvi Jagdishbhai Sheth, Dean Mitchell Wilson, Andreas P. Termin, Timothy Donald Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • Bicyclic derivatives as modulators of voltage gated ion channels
    Patent number: 8357702
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 22, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • BICYCLIC DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS
    Publication number: 20120308606
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Application
    Filed: June 29, 2012
    Publication date: December 6, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • Pyrimidines useful as modulators of voltage-gated ion channels
    Patent number: 8324220
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: December 4, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Mitchell Wilson, Esther Ann Martinborough, Timothy Donald Neubert, Andreas P. Termin, Jesus E. Gonzalez, III, Nicole Hilgraf
  • Piperidine and piperazine phenyl sulphonamides as modulators of ion channels
    Patent number: 8309587
    Abstract: The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: November 13, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Ann Martinborough, Lev Tyler Dewey Fanning, Urvi Jagdishbhai Sheth, Dean Mitchell Wilson, Andreas P. Termin, Timothy Donald Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • Bicyclic derivatives as modulators of voltage gated ION channels
    Patent number: 8236829
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: August 7, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • Bicyclic Derivatives as Modulators of Voltage Gated ION Channels
    Publication number: 20110112156
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 12, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • PYRIMIDINES USEFUL AS MODULATORS OF VOLTAGE-GATED ION CHANNELS
    Publication number: 20110003814
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 8, 2010
    Publication date: January 6, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Dean Mitchell Wilson, Esther Martinborough, Timothy Donald Neubert, Andreas Peter Termin, Jesus E. Gonzalez, III, Nicole Zimmerman
  • Pyrimidines useful as modulators of voltage-gated ion channels
    Patent number: 7816529
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: October 19, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Mitchell Wilson, Esther Martinborough, Timothy Donald Neubert, Andreas Peter Termin, Jesus E. Gonzalez, III, Nicole Zimmerman
  • Quinazolines useful as modulators of ion channels
    Patent number: 7678802
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: March 16, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmerman
  • Pyridinyl amides and imides for use as fungicides
    Patent number: 7074742
    Abstract: Compounds of Formula (I), their N-oxides and agriculturally suitable salts are disclosed which are useful as fungicides formula (I), (II) wherein A is a substituted pyridinyl ring; B is a substituted pyridinyl ring; W is C=L or SOn is O or S; R1 and R2 are each independently H; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted; R3 is H; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl or C3-C8 dialkylaminocarbonyl; R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted; X is O or S; and n is 1 or 2; provided that when W is C?O and R1, R2 and R3 are H; then B is other than 4-trifluoromethyl-3-pyridinyl, 2-chloro-4-pyridinyl and 2,6-dihalo-4-pyridinyl.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 11, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Timothy Donald Neubert, David Walter Piotrowski, Michael Paul Walker