Abstract: A pipette tip having lower, upper and central portions and a bore extending therethrough. The lower portion is elongated and projects in a first direction from the central portion, and is sized and shaped for insertion into a test-tube. The bore is adapted for aspirating and dispensing a large volume of the liquid. The upper portion projects from the central portion in a second direction opposing the first direction, and its terminal end is sized and shaped to sealingly engage an automated pipetting system. The central portion and a corresponding portion of the bore are enlarged with respect to both the upper and lower portions to allow the pipette tip to hold the large volume of the liquid. The central portion can have a cross-section substantially rectangular in shape. The cross-section can have a height at least substantially similar to the diameter of the lower portion of the pipette tip and a width significantly greater than the diameter of the lower portion of the pipette tip.