Patents by Inventor Timothy E. Corcoran

Timothy E. Corcoran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHALED DELIVERY OF PEPTIDE MIMICS OF CXCL10 FOR TARGETED ANTI-FIBROTIC THERAPY
    Publication number: 20220313777
    Abstract: Administration via inhalation of small peptides that mimic CXCL10 (FIBROKINE™ peptides) is described. The peptides can be administered as an aerosol, such as an aerosol with a droplet size small enough to reach lung alveoli. Use of the peptides to treat fibrosis, such as lung fibrosis, is described.
    Type: Application
    Filed: September 10, 2020
    Publication date: October 6, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Tuskegee University
    Inventors: Cecelia C. Yates, Timothy E. Corcoran, Zariel I. Johnson, Jesse Jaynes
  • Red blood cell membrane-derived microparticles and their use for the treatment of lung disease
    Patent number: 10596197
    Abstract: Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (RBC MPs), which are depleted of hemoglobin (Hb) and express phosphatidylserine on their surface, for the treatment of lung disease. Administration of RBC MPs to the lung via inhalation promotes the production of immunoregulatory cytokines (such as IL-10), and reduces inflammation and injury in the lung.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: March 24, 2020
    Assignee: University of Pittburgh—Of the Commonwealth System of Higher Education
    Inventors: Janet S. Lee, Timothy E. Corcoran, Valerian Kagan
  • RED BLOOD CELL MEMBRANE-DERIVED MICROPARTICLES AND THEIR USE FOR THE TREATMENT OF LUNG DISEASE
    Publication number: 20180271909
    Abstract: Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (RBC MPs), which are depleted of hemoglobin (Hb) and express phosphatidylserine on their surface, for the treatment of lung disease. Administration of RBC MPs to the lung via inhalation promotes the production of immunoregulatory cytokines (such as IL-10), and reduces inflammation and injury in the lung.
    Type: Application
    Filed: June 1, 2018
    Publication date: September 27, 2018
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Janet S. Lee, Timothy E. Corcoran, Valerian Kagan
  • Red blood cell membrane-derived microparticles and their use for the treatment of lung disease
    Patent number: 10004764
    Abstract: Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (RBC MPs), which are depleted of hemoglobin (Hb) and express phosphatidylserine on their surface, for the treatment of lung disease. Administration of RBC MPs to the lung via inhalation promotes the production of immunoregulatory cytokines (such as IL-10), and reduces inflammation and injury in the lung.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: June 26, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Janet S. Lee, Timothy E. Corcoran, Valerian Kagan
  • RED BLOOD CELL MEMBRANE-DERIVED MICROPARTICLES AND THEIR USE FOR THE TREATMENT OF LUNG DISEASE
    Publication number: 20160263156
    Abstract: Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (RBC MPs), which are depleted of hemoglobin (Hb) and express phosphatidylserine on their surface, for the treatment of lung disease. Administration of RBC MPs to the lung via inhalation promotes the production of immunoregulatory cytokines (such as IL-10), and reduces inflammation and injury in the lung.
    Type: Application
    Filed: November 6, 2014
    Publication date: September 15, 2016
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Janet S. Lee, Timothy E. Corcoran, Valerian Kagan