Patents by Inventor Timothy E. Long
Timothy E. Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230310609Abstract: Described in several embodiments herein are injectable hydrogels that are capable of attracting one or more cells, in situ. In some embodiments, the cells are cancer cells, such as cancer stem cells. Also described herein are methods of using the injectable hydrogels to fill a cavity in a subject. Also described herein are methods of treating a cancer by injecting an injectable hydrogel in a cavity in a subject formed from resecting a tumor and applying an external stimulus to the injected injectable hydrogel or area proximate to the injected injectable hydrogel.Type: ApplicationFiled: August 21, 2021Publication date: October 5, 2023Inventors: Zerin Mahzabin Khan, Scott S. Verbridge, Timothy E. Long, Eli Vlaisavlijevich
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Patent number: 11723875Abstract: A water-soluble polyurethane derived from: polyethylene glycol, polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol polymer, polypropylene glycol-block-polyethylene glycol-block-polypropylene and mixtures thereof, 1,1?-Carbonyldiimidazole, polyamine and mixtures thereof.Type: GrantFiled: March 26, 2019Date of Patent: August 15, 2023Assignee: The Procter & Gamble CompanyInventors: Travis Kyle Hodgdon, Douglas Michael Graham, Freddy Arthur Barnabas, Corey James Kenneally, Christopher Bryant Williams, Callie Elizabeth Zawaski, Timothy E Long, Allison M Pekkanen, Benjamin Tyler White
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Publication number: 20230235187Abstract: Polymer resins for the vat photopolymerization of thermoplastics are provided, in particular for the vat photopolymerization of thermoplastics with exception thermal stability and mechanical properties. In some aspects, the polymer resins are prepared by ring opening of an aromatic dianhydride with an alcohol containing an acrylate or methacrylate to produce a photocrosslinkable diacid monomer; conversion of the photocrosslinkable diacid monomer to a photocrosslinkable diacyl chloride; and polymerization of the photocrosslinkable diacyl chloride with an aromatic diamine to produce a photocrosslinkable precursor polymer. Upon crosslinking and drying, a thermal imidization can yield aromatic polyimide polymers with high yield and with micron-scale structural resolution.Type: ApplicationFiled: April 3, 2023Publication date: July 27, 2023Inventors: MARUTI HEGDE, TIMOTHY E. LONG, VISWANATH MEENAKSHISUNDARAM, CHRISTOPHER B. WILLIAMS, NICHOLAS CHARTRAIN
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Patent number: 11618832Abstract: Polymer resins for the vat photopolymerization of thermoplastics are provided, in particular for the vat photopolymerization of thermoplastics with exception thermal stability and mechanical properties. In some aspects, the polymer resins are prepared by ring opening of an aromatic dianhydride with an alcohol containing an acrylate or methacrylate to produce a photocrosslinkable diacid monomer; conversion of the photocrosslinkable diacid monomer to a photocrosslinkable diacyl chloride; and polymerization of the photocrosslinkable diacyl chloride with an aromatic diamine to produce a photocrosslinkable precursor polymer. Upon crosslinking and drying, a thermal imidization can yield aromatic polyimide polymers with high yield and with micron-scale structural resolution.Type: GrantFiled: August 17, 2017Date of Patent: April 4, 2023Assignee: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.Inventors: Maruti Hegde, Timothy E. Long, Viswanath Meenakshisundaram, Christopher B. Williams, Nicholas Chartrain
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Publication number: 20230038063Abstract: Photocurable colloid binders are provided that overcome deficiencies associated with 3D printing of high molecular weight polymers via VAT photopolymerization. Methods of additive manufacturing are also provided using the binders. The approaches described herein effectively decouple the viscosity-molecular weight relationship by synthesizing and processing photo-reactive aqueous colloids that are sequestered within a photocrosslinkable scaffold. Sequestering polymers within discrete internal phases prevents inter-particle entanglement of the polymer chains, thus ensuring low viscosity. VP of polymer colloids results in a solid green body embedded with high molecular weight polymer particles. A post-processing heated drying step allows the polymers to coalesce and further entangle, forming a semi-interpenetrating network with mechanical performance of the high molecular weight material. The resins can further include inorganic particles such as silica and other ceramics, metal particles, and the like.Type: ApplicationFiled: September 5, 2022Publication date: February 9, 2023Inventors: Timothy E. LONG, Viswanath MEENAKSHISUNDARAM, Philip J. SCOTT, Christopher B. WILLIAMS
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Patent number: 11529760Abstract: A method for manufacturing a three dimensional object includes steps of: providing a digital description of the object as a set of voxels; sequentially creating an actual set of voxels corresponding to the digital set of voxels. At least one voxel comprises a polymer derived from: polyol and an ionic monomer. The calculated charge density of the resulting polymer is 0.01 to 0.7 mEq/g. A three-dimensional object having at least one voxel. The at least one voxel including a polymer derived from: a polyol and an ionic monomer, and the calculated charge density of the resulting polymer is 0.01 to 0.7 mEq/g.Type: GrantFiled: October 29, 2019Date of Patent: December 20, 2022Assignees: The Procter & Gamble Company, Virginia Tech Intellectual Properties Inc.Inventors: Travis Kyle Hodgdon, Timothy E Long, Allison M Pekkanen, Abby Rebecca Whittington, Christopher Bryant Williams, Callie Elizabeth Zawaski, Douglas M Graham, Corey J Kenneally, Freddy Arthur Barnabas, Andre Stevenson
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Patent number: 11433601Abstract: Photocurable colloid binders are provided that overcome deficiencies associated with 3D printing of high molecular weight polymers via VAT photopolymerization. Methods of additive manufacturing are also provided using the binders. The approaches described herein effectively decouple the viscosity-molecular weight relationship by synthesizing and processing photo-reactive aqueous colloids that are sequestered within a photocrosslinkable scaffold. Sequestering polymers within discrete internal phases prevents inter-particle entanglement of the polymer chains, thus ensuring low viscosity. VP of polymer colloids results in a solid green body embedded with high molecular weight polymer particles. A post-processing heated drying step allows the polymers to coalesce and further entangle, forming a semi-interpenetrating network with mechanical performance of the high molecular weight material. The resins can further include inorganic particles such as silica and other ceramics, metal particles, and the like.Type: GrantFiled: March 26, 2020Date of Patent: September 6, 2022Assignee: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.Inventors: Timothy E. Long, Viswanath Meenakshisundaram, Philip J. Scott, Christopher B. Williams
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Publication number: 20220249366Abstract: The invention relates generally to methods of using a thiol-Michael addition hydrogel for providing intracavitary brachytherapy and/or displacing tissue and organs. The thiol-Michael addition hydrogel may be used as a packing material and an attenuation material for intracavitary brachytherapy applications. The invention also relates generally to a brachytherapy applicator, which may be used in conjunction with the thiol-Michael addition hydrogel and methods thereof. The invention also relates to a positioning device system for providing intracavitary brachytherapy treatment and a kit thereof.Type: ApplicationFiled: January 18, 2022Publication date: August 11, 2022Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.Inventors: Timothy Norman SHOWALTER, Timothy E. LONG, Nicholas MOON
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Publication number: 20220088851Abstract: Photocurable colloid binders are provided that overcome deficiencies associated with 3D printing of high molecular weight polymers via VAT photopolymerization. Methods of additive manufacturing are also provided using the binders. The approaches described herein effectively decouple the viscosity-molecular weight relationship by synthesizing and processing photo-reactive aqueous colloids that are sequestered within a photocrosslinkable scaffold. Sequestering polymers within discrete internal phases prevents inter-particle entanglement of the polymer chains, thus ensuring low viscosity. VP of polymer colloids results in a solid green body embedded with high molecular weight polymer particles. A post-processing heated drying step allows the polymers to coalesce and further entangle, forming a semi-interpenetrating network with mechanical performance of the high molecular weight material. The resins can further include inorganic particles such as silica and other ceramics, metal particles, and the like.Type: ApplicationFiled: March 26, 2020Publication date: March 24, 2022Inventors: Timothy E. LONG, Viswanath MEENAKSHISUNDARAM, Philip J. SCOTT, Christopher B. WILLIAMS
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BINDERS AND METHODS OF BINDER JETTING INCLUDING BRANCHED POLYMER BINDERS AND ARTICLES MADE THEREFROM
Publication number: 20220088855Abstract: Binders and methods of binder jetting are provided based on the use of branched polymer binders. The applicants have found that, even more so than the molecular weight, the ability to achieve higher maximum printable concentrations leads to higher densities and improved structural properties of the manufactured articles. The methods can be used for a variety of articles from metal parts to structural ceramics, to tablets and other oral dosage forms. The branched chain polymers can include a short-chain branched polymer; a long-chained branched polymer; a hyper-branched polymer, a cyclic polymer; a comb-type polymer; a 3-arm star type polymer, a 4-arm star type polymer, a dendritic polymer, and a combination thereof. The branched-chain polymer can include various polymers such as polyvinylpyrrolidone, poly(vinyl alcohol), or poly(acrylic acid).Type: ApplicationFiled: March 25, 2020Publication date: March 24, 2022Inventors: Christopher B. WILLIAMS, Emily M. WILTS, Timothy E. LONG, Da MA -
Publication number: 20200369831Abstract: In various aspects, a polymer resin is provided for vat photopolymerization. The resin can include a polyamic acid salt formed from the addition of a photocrosslinkable amine to a polyamic acid. The resin can include a photoinitiator suitable for initiating crosslinking of the photocrosslinkable amine when exposed to a light source of a suitable wavelength and intensity. The polyamic acid can be formed, for instance, by the addition of a diamine to a suitable dianhydride. Methods of additive manufacturing using the resins are also provided.Type: ApplicationFiled: February 13, 2019Publication date: November 26, 2020Inventors: Jana Herzberger, Timothy E. Long, Viswanath Meenakshisundaram, Christopher B. Williams
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Patent number: 10767005Abstract: Bibenzoate copolyesters are based on (4,4?-biphenyl dicarboxylic acid-co-3,4?-biphenyl dicarboxylic acid) as the diacid component, and on an alicyclic diol compound such as 1,4-cyclohexanedimethanol as a portion of the diol component. Copolyesters are based on 4,4?-biphenyl dicarboxylic acid, and/or 3,4?-biphenyl dicarboxylic acid as the diacid component and may include a multifunctional acid. Copolymers may optionally base an essentially amorphous morphology, high glass transition temperature, high elongation at break, and/or high melting temperature.Type: GrantFiled: October 7, 2016Date of Patent: September 8, 2020Assignees: ExxonMobil Chemical Patents Inc., Virginia Tech Intellectual Properties, IncInventors: Ryan J. Mondschein, Haoyu Liu, Ting Chen, Timothy E. Long, S. Richard Turner
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Patent number: 10759900Abstract: Liquid crystalline hydroquinone-3,4?-biphenyl dicarboxylate polyesters, and methods of making them. The polyesters may be melt processed at a temperature below the thermal decomposition temperature and the isotropic temperature, and may form a liquid crystalline glass phase. The polyesters may be formed by polycondensation of hydroquinone or a hydroquinone derivative with 3,4?-biphenyl dicarboxylic acid.Type: GrantFiled: May 6, 2020Date of Patent: September 1, 2020Assignees: ExxonMobil Chemical Patents Inc., Virginia Tech Intellectual Property, Inc.Inventors: Katherine V. Heifferon, Timothy E. Long, S. Richard Turner, Yong Yang, Syamal Tallury, Ting Chen, Javier Guzman
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Publication number: 20200270396Abstract: Liquid crystalline hydroquinone-3,4?-biphenyl dicarboxylate polyesters, and methods of making them. The polyesters may be melt processed at a temperature below the thermal decomposition temperature and the isotropic temperature, and may form a liquid crystalline glass phase. The polyesters may be formed by polycondensation of hydroquinone or a hydroquinone derivative with 3,4?-biphenyl dicarboxylic acid.Type: ApplicationFiled: May 6, 2020Publication date: August 27, 2020Inventors: Katherine V. Heifferon, Timothy E. Long, S. Richard Turner, Yong Yang, Syamal Tallury, Ting Chen, Javier Guzman
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Publication number: 20200262970Abstract: Copolyesters having improved properties based on a diacid component of 4,4?-biphenyl dicarboxylic acid or 3,4?-biphenyl dicarboxylic acid and a mixed diol component, such as 1,4 cyclohexanedimethanol (CHDM) with ethylene glycol or neopentyl glycol (NPG), e.g., poly(4,4?-biphenyl dicarboxylate-(ethylene glycol-co-CHDM)), poly(4,4?-biphenyl dicarboxylate-(NPG-co-CHDM)), poly(3,4?-biphenyl dicarboxylate-(ethylene glycol-co-CHDM)), poly(3,4?-biphenyl dicarboxylate-(NPG-co-CHDM)); methods of making the copolyesters; and shaped articles made of the copolyesters. Also, polyesters based on biphenyl dicarboxylic acid and NPG; methods of making the polyesters; and shaped articles made of the polyesters.Type: ApplicationFiled: October 18, 2017Publication date: August 20, 2020Inventors: Hans Eliot Edling, Haoyu Liu, Ryan J. Mondshein, Timothy E. Long, S. Richard Turner, Ting Chen
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Publication number: 20200262971Abstract: Copolyesters are based on a diacid component containing terephthalate and 4,4?-biphenyl dicarboxylate or 3,4?-biphenyl dicarboxylate, and a diol component containing an alkylene diol, e.g., ethylene glycol or NPG, and an alicyclic polyhydroxyl compound, e.g., CHDM. The copolyesters may have a glass transition temperature more than 100° C. and mechanical, thermal and/or barrier characteristics at least comparable to some commercially available copolyesters. A method to control the morphology and properties of a copolyester involves contacting diacid and diol components in the presence of a catalyst, selecting proportions of terephthalic and 4,4?-biphenyl dicarboxylic or 3,4?-biphenyl dicarboxylic acids or ester producing equivalents thereof in the diacid component, and selecting the alkylene diol and proportions of the CHDM (or other alicyclic polyhydroxyl compound) and the alkylene diol in the diol component, to obtain the desired morphology and other properties.Type: ApplicationFiled: October 7, 2016Publication date: August 20, 2020Inventors: Haoyu Liu, Ryan J. Mondschein, Ting Chen, Timothy E. Long, S. Richard Turner
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Patent number: 10738148Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters have lower glass transition temperatures than polyesters of comparable molecular weight.Type: GrantFiled: August 13, 2018Date of Patent: August 11, 2020Assignee: Elevance Renewable Sciences, Inc.Inventors: Ashley M. Nelson, Keren Zhang, Timothy E. Long, Paul A. Bertin
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Publication number: 20200248015Abstract: Polymer resins for the vat photopolymerization of thermoplastics are provided, in particular for the vat photopolymerization of thermoplastics with exception thermal stability and mechanical properties. In some aspects, the polymer resins are prepared by ring opening of an aromatic dianhydride with an alcohol containing an acrylate or methacrylate to produce a photocrosslinkable diacid monomer; conversion of the photocrosslinkable diacid monomer to a photocrosslinkable diacyl chloride; and polymerization of the photocrosslinkable diacyl chloride with an aromatic diamine to produce a photocrosslinkable precursor polymer. Upon crosslinking and drying, a thermal imidization can yield aromatic polyimide polymers with high yield and with micron-scale structural resolution.Type: ApplicationFiled: August 17, 2017Publication date: August 6, 2020Inventors: MARUTI HEDGE, TIMOTHY E. LONG, VISWANATH MEENAKSHISUNDARAM, CHRISTOPHER B. WILLIAMS, NICHOLAS CHARTRAIN
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Patent number: 10669451Abstract: A roof structure comprises a roof membrane and a roof substrate. A first surface of the roof membrane is adhered to the roof substrate by a two component adhesive, the adhesive being capable of adhering the first surface of the roof membrane to the roof substrate without the use of a high VOC solvent. The two component adhesive includes a Michael donor and a Michael acceptor, and the Michael donor and the Michael acceptor react to form an adhesive film.Type: GrantFiled: February 21, 2019Date of Patent: June 2, 2020Assignee: Carlisle Construction Materials, LLCInventors: Daniel J. Cotsakis, William J. Schneider, Michael J. Scanish, Anil G. Shenoy, Timothy E. Long, Sam Richard Turner, Alison R. Schultz
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Publication number: 20200086551Abstract: A method for manufacturing a three dimensional object includes steps of: providing a digital description of the object as a set of voxels; sequentially creating an actual set of voxels corresponding to the digital set of voxels. At least one voxel comprises a polymer derived from: polyol and an ionic monomer. The calculated charge density of the resulting polymer is 0.01 to 0.7 mEq/g. A three-dimensional object having at least one voxel. The at least one voxel including a polymer derived from: a polyol and an ionic monomer, and the calculated charge density of the resulting polymer is 0.01 to 0.7 mEq/g.Type: ApplicationFiled: October 29, 2019Publication date: March 19, 2020Inventors: Travis Kyle Hodgdon, Timothy E Long, Allison M Pekkanen, Abby Rebecca Whittington, Christopher Bryant Williams, Callie Elizabeth Zawaski, Douglas M Graham, Corey J Kenneally, Freddy Arthur Barnabas, Andre Stevenson