Patents by Inventor Timothy E. O'Toole

Timothy E. O'Toole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying inhibitors of integrin activation
    Patent number: 5523209
    Abstract: The invention features a method for inhibiting the ligand binding of an integrin in a cell involving introducing into the cell a compound which inhibits integrin activation, a method for identifying compounds which inhibit integrin activation, and chimeric integrin molecules.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: June 4, 1996
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Timothy E. O'Toole
  • Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation
    Patent number: 5306620
    Abstract: An integrin-activating antibody is disclosed that immunoreacts with an integrin and when immunoreacted increases the binding affinity of the integrin for binding to ligands specific for the integrin. The antibody also immunoreacts with a ligand-induced binding site (LIBS) on the integrin when the integrin is specifically bound to its ligand. Further disclosed are therapeutic compositions and methods for promoting cell adhesion using the disclosed integrin-activating antibodies.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: April 26, 1994
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Timothy E. O'Toole, Edward F. Plow, Andrew L. Frelinger, III