Abstract: The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.

Abstract: Illuminated optical sight reticle assemblies have a transparent element having opposed major surfaces and a periphery, a reticle image formed on one of the major surfaces of the transparent element, the reticle image defining a selected primary point, and an optical fiber having a first free end positioned proximate the selected primary point and an opposed second end away from the first end and proximate to an illumination source. There may be a fiber support structure having a periphery, and a span element extending from the periphery supporting the fiber. The fiber support structure may be a wire reticle. The fiber support structure periphery may have a first thickness, and the span may have a lesser second thickness. The fiber support structure periphery may be a ring. The span may include a first elongated element extending diametrically across the ring.

Abstract: A broadcast signal receiver comprises a text data receiver for receiving broadcast text data for display to a user in relation to a user interface; a text-to-speech (TTS) converter for converting received text data into an audio speech signal, the TTS converter being operable to detect whether a word for conversion is included in a stored list of words for conversion and, if so, to convert that word according to a conversion defined by the stored list; and if not, to convert that word according to a set of predetermined conversion rules; a conversion memory storing the list of words for conversion by the TTS converter; and an update receiver for receiving additional words and associated conversions for storage in the conversion memory.

Abstract: The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.

Abstract: A television apparatus (20) including a display (22) and an audio transducer (24,28) for reproducing video and audio component parts of a television signal. A processor (40) is provided for separating from the television signal an audio descriptor component part for providing an audio description of a corresponding video component part of the television signal. A controller (46) selectively controls the television apparatus to operate in one of an audio descriptor mode in which an audio descriptor component part is reproduced by the audio transducer (24,28) at the same time as the display (22) reproduces the respective corresponding video component part and a standard mode in which the audio descriptor component part is not reproduced. A user operable interface (30,50,48) is provided for selectively selecting between the standard mode and the audio descriptor mode. The controller (46) is configured to drive the display (42) to provide a mode image (52) providing an indication of the selective mode.

Abstract: A broadcast signal receiver comprises a text data receiver for receiving broadcast text data for display to a user in relation to a user interface; a text-to-speech (TTS) converter for converting received text data into an audio speech signal, the TTS converter being operable to detect whether a word for conversion is included in a stored list of words for conversion and, if so, to convert that word according to a conversion defined by the stored list; and if not, to convert that word according to a set of predetermined conversion rules; a conversion memory storing the list of words for conversion by the TTS converter; and an update receiver for receiving additional words and associated conversions for storage in the conversion memory.

Abstract: A television apparatus (20) including a display (22) and an audio transducer (24,28) for reproducing video and audio component parts of a television signal. A processor (40) is provided for separating from the television signal an audio descriptor component part for providing an audio description of a corresponding video component part of the television signal. A controller (46) selectively controls the television apparatus to operate in one of an audio descriptor mode in which an audio descriptor component part is reproduced by the audio transducer (24,28) at the same time as the display (22) reproduces the respective corresponding video component part and a standard mode in which the audio descriptor component part is not reproduced. A user operable interface (30,50,48) is provided for selectively selecting between the standard mode and the audio descriptor mode. The controller (46) is configured to drive the display (42) to provide a mode image (52) providing an indication of the selective mode.

Abstract: An image and associated information provided in a Digital Imaging and Communications in Medicine (DICOM) dataset can be delivered to a web browser. The DICOM dataset is separated into image data and associated data. The image data is translated into an image file and the associated data in an associated file is described using a format which is understood by the web browser. The image file and associated file are transmitted over a communications network to the web browser and the web browser is then used to display the image and associated information from the image file and associated file respectively.

Abstract: A receiver-decoder apparatus has a receiver-decoder circuit capable of receiving and decoding broadcast television signals of different services to generate therefrom a video signal for display of an image on a display device. The apparatus has an EPG generator for generating a signal for display on said display device of an electronic program guide listing services and events in respect of those services. The EPG generator identifies further events which are related to respective events in the electronic program guide. In the electronic program guide, the further events are shown associated with the events to which they are related. The events in respect of each service are shown by blocks arranged along a time line. The further events are shown by adjacent blocks scaled to create a perspective view of the blocks of the further events being more distant than the blocks of the events to which they are related.

Abstract: The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.

Abstract: A frame for a gaseous fueled vehicle is provided. The frame includes a floor pan, a tunnel positioned centrally and longitudinally in the floor pan extending a full length of the frame, and a tank integrated into the tunnel, where the tank is circular in cross-section and has a variable diameter. The tunnel may also integrate two or more tanks.

Abstract: There is provided a method of providing a receiver of a transmitted stream of video data for an ongoing succession of video frames with one or more images representing that stream of video data. Indicator data is created which identifies individual frames in the stream of video data for use as the one or more images. The indicator data is then transmitted to the receiver and used by the receiver to capture frames for use as representative images. The representative images may be used as part of an electronic program guide, for instance when the frames are captured from earlier transmitted trailers. Also, the representative images can be used when recording a received transmitted program, in particular in conjunction with indexing information for playback of the recorded program.

Abstract: A frame for a gaseous fueled vehicle is provided. The frame includes a floor pan, a tunnel positioned centrally and longitudinally in the floor pan extending a full length of the frame, and a tank integrated into the tunnel, where the tank is circular in cross-section and has a variable diameter. The tunnel may also integrate two or more tanks.

Abstract: A frame for a gaseous fueled vehicle, said frame comprising: a floor pan, a tunnel positioned centrally and longitudinally in said floor pan extending the full length of said frame, and a tank integrated into said tunnel. The tunnel may also integrate two or more tanks.

Abstract: A target detection method collects spatial data relating to a target at an instant in time. This data is converted to an appropriate coordinate system, such as Cartesian coordinates. A centroid of the target is determined. Predictions of the centroid are made at subsequent time intervals. The predicted centroids are averaged with the current determined centroids. When the closest centroid position of the target is determined, an indication is provided for detonating the warhead of a projectile.

Abstract: Disclosed is a method of recovering tissue plasminogen activator from media and cell extracts. The method comprises contacting the tPA-containing solution with a silicaceous matrix material comprising covalently bound polymer having plural anionic groups. Selective elution of the tPA can produce eluants of high specific activity. The method can succeed in recovering greater than 90% of the tPA activity from the crude solution.

Abstract: Disclosed is a method of recovering urokinase compounds from media and cell extracts. The method comprises contacting the urokinase compound-containing solution with a silicaceous matrix material comprising covalently bound polymer having plural anionic groups. Selective elution of the urokinase compound can produce elutants of high specific activity. The method can succeed in recovering greater than 90% of the urokinase activity from the crude solution.