Abstract: An abrading device includes a funnel and an outlet orifice disposed within the funnel for passage of abrasive material, where a distance between the outlet orifice and a bottom end of the funnel is adjustable. An exhaust tube is coupled to the funnel for withdrawal of spent abrasive material from the funnel.

Abstract: Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Abstract: A portable flexure fixture including a fixture housing, a translatable plug, a load ring, and a support ring. The fixture housing includes a first end opposite a second end, a plug receiving opening extending into the first end and a test opening extending into the second end. The support ring is disposed in the fixture housing. The translatable plug is insertable into the plug receiving opening of the fixture housing and is translatable in both a sample engaging direction and a sample releasing direction. Further, the load ring is coupled to the translatable plug and is positioned at a sample facing end of the translatable plug such that translation of the translatable plug in the sample engaging direction translates the load ring in the sample engaging direction and translation of the translatable plug in the sample releasing direction translates the load ring in the sample releasing direction.

Abstract: A portable flexure fixture including a fixture housing, a translatable plug, a load ring, and a support ring. The fixture housing includes a first end opposite a second end, a plug receiving opening extending into the first end and a test opening extending into the second end. The support ring is disposed in the fixture housing. The translatable plug is insertable into the plug receiving opening of the fixture housing and is translatable in both a sample engaging direction and a sample releasing direction. Further, the load ring is coupled to the translatable plug and is positioned at a sample facing end of the translatable plug such that translation of the translatable plug in the sample engaging direction translates the load ring in the sample engaging direction and translation of the translatable plug in the sample releasing direction translates the load ring in the sample releasing direction.

Abstract: Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Abstract: Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Abstract: An abrading device includes a funnel and an outlet orifice disposed within the funnel for passage of abrasive material, where a distance between the outlet orifice and a bottom end of the funnel is adjustable. An exhaust tube is coupled to the funnel for withdrawal of spent abrasive material from the funnel.

Abstract: An abrading device includes a funnel and an outlet orifice disposed within the funnel for passage of abrasive material, where a distance between the outlet orifice and a bottom end of the funnel is adjustable. An exhaust tube is coupled to the funnel for withdrawal of spent abrasive material from the funnel.

Abstract: Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.

Abstract: An abrading device includes a funnel and an outlet orifice disposed within the funnel for passage of abrasive material, where a distance between the outlet orifice and a bottom end of the funnel is adjustable. An exhaust tube is coupled to the funnel for withdrawal of spent abrasive material from the funnel.

Abstract: Provided herein are methods that include (i) determining a level of soluble ST2 in a biological sample from a subject, (i) comparing the level of soluble ST2 in the biological sample to a reference level of soluble ST2 (e.g., a level of soluble ST2 in the subject at an earlier time point), and (iii) selecting, implanting, replacing, or reprogramming an implanted cardiac device, e.g., an ICD, CRT, or CRT-D device, for a subject having an elevated level of soluble ST2 in the biological sample compared to the reference level of soluble ST2, or selecting a subject for participation in, or stratifying a subject participating in, a clinical study of a treatment for reducing the risk of a ventricular tachyarrhythmia (VTA) event. Also provided are methods for evaluating the risk of a VTA event in a subject. Also provided are kits for performing any of these methods.