Abstract: A medicament packaging assembly for installation in a medicament delivery device is disclosed. The packaging assembly comprises a cartridge having a medicament chamber, a sealing element for sealing a distal end of the medicament chamber, a sealing element release member, a cannula and a removable cap member. The assembly is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The packaging assembly further comprises a first chamber defined in part by the cap member and arranged for receiving the cannula such that at least a distal end of the cannula is sealed in the first chamber when the cap member is in place, and a second chamber defined in part by the sealing element and arranged for receiving the release member.

Abstract: A medicament delivery device is disclosed, comprising a cartridge assembly that comprises a cartridge having a medicament chamber for containing a medicament, a sealing element for sealing a distal end of the medicament chamber and a coupling element attached to the cartridge. The device also includes a sealing element release member, a cannula for delivery of the medicament, and a removable cap. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. A proximal end of the release member is sealed in a release member chamber defined in part by, the sealing element and in part by the coupling element.

Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

Abstract: A leading edge structure for providing an aerodynamic surface of an aircraft is disclosed having a skin structure, the skin structure providing an outer aerodynamic surface and an inner surface, both surfaces extending in a chordwise and spanwise direction of the structure, and a plurality of structural members, each structural member being connected to the inner surface of the skin structure and extending in the chordwise direction along the inner surface, wherein the structural members are integrally formed with the inner surface of the skin structure. The disclosure is also related to an aircraft wing, aircraft tailplane, wing box structure, wing or wing structure and an aircraft including the leading edge structure.

Abstract: A medicament delivery device (100; 300; 400) comprises a chassis (124), a drive element (166) for driving a stopper (22) to expel the medicament through a cannula (144). A carrier (126) is arranged for movement with respect to the chassis (124). Insertion means (130, 202) biases the carrier (126) in an insertion direction. A control part (132) is biased for rotation with respect to the carrier (126). A locking element (176) prevents rotation of the control part (132) in an initial state. The locking element (176) is coupled to the drive element (166) such that the control part (132) is released for rotation when the drive element (166) reaches an activation position during a delivery stroke. Rotation of the control part (132) through a predetermined angle causes decoupling of the insertion means (130, 202) from the carrier (126) to allow movement of the carrier (126) in a retraction direction after the end of the delivery stroke.

Abstract: A medicament packaging assembly for installation in a medicament delivery device is disclosed. The packaging assembly comprises a cartridge having a medicament chamber, a sealing element for sealing a distal end of the medicament chamber, a sealing element release member, a cannula and a removable cap member. The assembly is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula.

Abstract: A system and method for resource estimation of an additive manufacturing device is disclosed herein. The system includes at least one processor and one or more software modules. The processor executes the one or more software modules to determine a number of parts that can be manufactured per manufacturing run, estimate manufacturing time to manufacture a specified number of parts, and determine a total cost to manufacture the number of parts with the additive manufacturing device. The one or more software modules can compare the total cost to the cost of a current manufacturing method.

Abstract: A medicament delivery device comprising a cannula for delivery of medicament, a cartridge assembly comprising a cartridge having a medicament chamber and a collar adjacent a distal end opening of the chamber, a sealing element for sealing the distal end opening, and a coupling element for retaining the sealing element against a distal end of the cartridge. The device further comprises a hub assembly comprising a hub body and a sealing element release member. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The coupling element comprises an annular clamping portion for applying a clamping force to the sealing element to seal the sealing element against the distal end of the cartridge, and a generally tubular engagement portion.

Abstract: A medicament delivery device is disclosed, comprising a cartridge assembly that comprises a cartridge having a medicament chamber for containing a medicament, a sealing element for sealing a distal end of the medicament chamber and a coupling element attached to the cartridge. The device also includes a sealing element release member, a cannula for delivery of the medicament, and a removable cap. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. A proximal end of the release member is sealed in a release member chamber defined in part by, the sealing element and in part by the coupling element.

Abstract: A cartridge (100) for packaging a medicament and being suitable for use with multiple different types of dosing device is described, together with dosing devices and adaptors for dosing devices. The cartridge includes a generally tubular body (102) having an interior cavity (104), a closure member (106) disposed at a distal end of the body and comprising a sealing element (128), a piston member (108) disposed in the cavity to contain the medicament between the piston member and the sealing element (128), a coupling element (114) disposed at the distal end of the body for coupling the cartridge to a dosing device (200) or to an adaptor for a dosing device, and a seal arrangement (126, 129) for receiving a sealing element release member (214) of the dosing device or adaptor.

Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

Abstract: A system and method for resource estimation of an additive manufacturing device is disclosed herein. The system includes at least one processor and one or more software modules. The processor executes the one or more software modules to determine a number of parts that can be manufactured per manufacturing run, estimate manufacturing time to manufacture a specified number of parts, and determine a total cost to manufacture the number of parts with the additive manufacturing device. The one or more software modules can compare the total cost to the cost of a current manufacturing method.

Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.

Abstract: A needle tip (22) for being connected and disconnected in use from a needle tip support (16), comprises a needle (24) having a forward end and a rearward end and, a connector secured to the needle intermediate its ends. The connector comprises two arms (28) each extending outwardly and rearwardly relative to the needle (16) and configured to be coupled and uncoupled in use from said needle tip support, and the arms are disposed on opposite sides of the needle. Also disclosed are arrangements for storing, dispensing and later disposing such needle tips, as well as coupling interfaces between the needle tip and a needle support cap to which it is fitted in use.

Abstract: Various needle tip storage and removal devices are disclosed which include a housing with a separate storage compartment and removal compartment for receiving a needle tip. The removal compartment is designed to hold securely a used needle tip. The removal compartment may have a one way snap engagement and/or a movable closure element.

Abstract: A medicament delivery device (100; 300; 400) comprises a chassis (124), a drive element (166) for driving a stopper (22) to expel the medicament through a cannula (144). A carrier (126) is arranged for movement with respect to the chassis (124). Insertion means (130, 202) biases the carrier (126) in an insertion direction. A control part (132) is biased for rotation with respect to the carrier (126). A locking element (176) prevents rotation of the control part (132) in an initial state. The locking element (176) is coupled to the drive element (166) such that the control part (132) is released for rotation when the drive element (166) reaches an activation position during a delivery stroke. Rotation of the control part (132) through a predetermined angle causes decoupling of the insertion means (130, 202) from the carrier (126) to allow movement of the carrier (126) in a retraction direction after the end of the delivery stroke.

Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.

Abstract: The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease.

Abstract: A leading edge structure for providing an aerodynamic surface of an aircraft is disclosed having a skin structure, the skin structure providing an outer aerodynamic surface and an inner surface, both surfaces extending in a chordwise and spanwise direction of the structure, and a plurality of structural members, each structural member being connected to the inner surface of the skin structure and extending in the chordwise direction along the inner surface, wherein the structural members are integrally formed with the inner surface of the skin structure. The disclosure is also related to an aircraft wing, aircraft tailplane, wing box structure, wing or wing structure and an aircraft including the leading edge structure.