Patent number: 7951793
Abstract: Compounds are provided which have the structure wherein Z1 is (CH2)q or C?O; Z2 is (CH2)p or C?O; D is —CH? or C?O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C; and A, B, R1, R2, R2a, R4, R3, E, Z and Y are as defined herein, which compounds are useful in treating diabetes and related diseases.
Type:
Grant
Filed:
July 18, 2007
Date of Patent:
May 31, 2011
Assignee:
Bristol-Myers Squibb Company
Inventors:
Peter T. W. Cheng, Sean Chen, Pratik Devasthale, Charles Z. Ding, Timothy F. Herpin, Shung Wu, Hao Zhang, Wei Wang, Xiang-Yang Ye
Patent number: 7279485
Abstract: Substituted heterocyclic derivatives are provided which have the structure wherein Z1 is (CH2)q or C?O; Z2 is (CH2)p or C?O; D is —CH? or C?O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4, X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C; A, B, R1, R2, R2a, R2b, R4, R3, E, Z and Y are as defined herein. In addition, a method is provided for treating diabetes, Type 2 diabetes, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, or atherosclerosis, wherein the substituted heterocyclic derivatives are administered in a therapeutically effective amount to a patient.
Type:
Grant
Filed:
July 8, 2003
Date of Patent:
October 9, 2007
Assignee:
Bristol-Myers Squibb Company
Inventors:
Peter T. W. Cheng, Sean Chen, Pratik Devasthale, Charles Z. Ding, Timothy F. Herpin, Shung Wu, Hao Zhang, Wei Wang, Xiang-Yang Ye