Patents by Inventor Timothy F. Kowalik

Timothy F. Kowalik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Virally-encoded RNAs as substrates, inhibitors and delivery vehicles for RNAi
    Patent number: 7776569
    Abstract: The present invention provides methods for identifying druggable targets in assays that feature compositions, cells and/or organisms having structured viral non-coding RNAs (svRNAs) and an RNA interference (RNAi) pathway. Methods for identifying antiviral agents and creating vaccines are also featured. The invention further provides methods for inhibiting RNAi involving svRNAs or inhibitory derivatives thereof. The invention also provides compositions for delivering siRNA and miRNA molecules derived from svRNA loci and methods of use thereof. Therapeutic methods are also featured.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: August 17, 2010
    Assignee: University of Massachusetts
    Inventors: Timothy F. Kowalik, Bradford M. Stadler
  • RNAi targeting of viruses
    Publication number: 20040248839
    Abstract: The invention relates to methods and compositions that inhibit viral replication, e.g., CMV replication, within a host or host cell. Methods and compositions of the invention utilize RNA interference to block the translation of mRNA into proteins which are important or essential to viral replication. The method and compositions can be used to study CMV infection in in vitro cell culture and to treat CMV infection in non-human primates and human subjects.
    Type: Application
    Filed: February 5, 2004
    Publication date: December 9, 2004
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventor: Timothy F. Kowalik