Patents by Inventor Timothy F. Smith
Timothy F. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240085949Abstract: An apparatus can include a display, a facial interface, and a connector between the display and the facial interface. The facial interface can at least translate or rotate relative to the display via the connector.Type: ApplicationFiled: September 1, 2023Publication date: March 14, 2024Inventors: Darshan R. Kasar, Samuel G. Smith, Jonathan M. Anderson, Erin M. Bosch, Muhammad F. Hossain, Liam R. Martinez, Andrew Gallaher, Ian A. Guy, Brian Baillargeon, Keith W. Kirkwood, Timothy J. Rasmussen
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Patent number: 11911764Abstract: The invention provides novel sample chambers, sample analysis units, multi-well plates, and imaging and analytical systems as well as methods for accurate, efficient and high-throughput imaging, measurement and analysis of diverse types of biological cells to obtain information such as cell count, cell size, cell concentration, cell sub-population, cell morphology, cell viability, etc.Type: GrantFiled: February 21, 2019Date of Patent: February 27, 2024Assignee: Nexcelom Bioscience LLCInventors: Peter Y. Li, Jean Qiu, Leo L. Chan, Justin R. Hascup, Timothy F. Smith, Todd R. Sobolewski, Nicholas N. Shaw
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Publication number: 20210069696Abstract: The invention provides novel sample chambers, sample analysis units, multi-well plates, and imaging and analytical systems as well as methods for accurate, efficient and high-throughput imaging, measurement and analysis of diverse types of biological cells to obtain information such as cell count, cell size, cell concentration, cell sub-population, cell morphology, cell viability, etc.Type: ApplicationFiled: February 21, 2019Publication date: March 11, 2021Inventors: Peter Y. Li, Jean Qiu, Leo L. Chan, Justin R. Hascup, Timothy F. Smith, Todd R. Sobolewski, Nicholas N. Shaw
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Patent number: 8551716Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: GrantFiled: June 19, 2012Date of Patent: October 8, 2013Assignee: X-Body, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, Bo Lin
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Publication number: 20130130926Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: ApplicationFiled: June 19, 2012Publication date: May 23, 2013Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Patent number: 8202735Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: GrantFiled: April 13, 2010Date of Patent: June 19, 2012Assignee: X-Body, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Patent number: 8061220Abstract: A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.Type: GrantFiled: October 23, 2009Date of Patent: November 22, 2011Assignee: SRU Biosystems, Inc.Inventors: Lance G. Laing, Timothy F. Smith, John Gerstenmeier, III, Gangadhar Jogikalmath
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Patent number: 7927822Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: GrantFiled: December 8, 2006Date of Patent: April 19, 2011Assignee: SRU Biosystems, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Patent number: 7832291Abstract: A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.Type: GrantFiled: July 15, 2009Date of Patent: November 16, 2010Assignee: SRU Biosystems, Inc.Inventors: Lance G. Laing, Timothy F. Smith, John Gerstenmeier, III, Gangadhar Jogikalmath
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Publication number: 20100196925Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.Type: ApplicationFiled: April 13, 2010Publication date: August 5, 2010Applicant: SRU Biosystems, Inc.Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, William C. Karl, Bo Lin
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Publication number: 20100043571Abstract: A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.Type: ApplicationFiled: October 23, 2009Publication date: February 25, 2010Inventors: Lance G. Laing, Timothy F. Smith, John Gerstenmeier, III, Gangadhar Jogikalmath
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Patent number: 7628085Abstract: A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.Type: GrantFiled: November 17, 2006Date of Patent: December 8, 2009Assignee: SRU Biosystems, Inc.Inventors: Lance G. Laing, Timothy F. Smith, John Gerstenmaier, III, Gangadhar Jogikalmath
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Publication number: 20090282931Abstract: A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.Type: ApplicationFiled: July 15, 2009Publication date: November 19, 2009Inventors: Lance G. Laing, Timothy F. Smith, John Gerstenmeier, III, Gangadhar Jogikalmath
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Publication number: 20080115567Abstract: A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.Type: ApplicationFiled: November 17, 2006Publication date: May 22, 2008Inventors: Lance G. Laing, Timothy F. Smith, John Gerstenmaier, Gangadhar Jogikalmath
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Patent number: 6838680Abstract: An optical detection and orientation device is provided comprising a housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focusing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and a moveable carrier for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in detecting fluorophores in the channel during operations involving fluorescent signals.Type: GrantFiled: July 23, 2002Date of Patent: January 4, 2005Assignee: Aclara Biosciences, Inc.Inventors: Kevin Maher, Timothy F. Smith, Torleif O. Bjornson
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Patent number: 6614030Abstract: An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.Type: GrantFiled: May 15, 2002Date of Patent: September 2, 2003Assignee: Aclara Biosciences, Inc.Inventors: Kevin Maher, Timothy F. Smith, Torleif Ove Bjornson
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Publication number: 20030038248Abstract: An optical detection and orientation device is provided comprising a housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focusing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and a moveable carrier for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in detecting fluorophores in the channel during operations involving fluorescent signals.Type: ApplicationFiled: July 23, 2002Publication date: February 27, 2003Inventors: Kevin Maher, Timothy F. Smith, Torleif O. Bjornson
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Publication number: 20020179849Abstract: An optical detection and orientation device is provided comprising housing having an excitation light source. an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.Type: ApplicationFiled: May 15, 2002Publication date: December 5, 2002Inventors: Kevin Maher, Timothy F. Smith, Torleif Ove Bjornson
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Publication number: 20020092767Abstract: Microfluidic unit arrays and their use are provided for performing in parallel a plurality of operations. The units are arrayed in a format comparable to microtiter well formats, so that transfer by a dispenser having a plurality of dispensing units can be performed with the same footprint, the format of the source and microfluidic unit receiving reservoirs are substantially the same. Operations are carried out simultaneously under comparable conditions, which permits more exact comparisons between the operations.Type: ApplicationFiled: November 28, 2001Publication date: July 18, 2002Applicant: ACLARA BioSciences, Inc.Inventors: Torleif Ove Bjornson, Timothy F. Smith
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Patent number: 6399952Abstract: An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.Type: GrantFiled: May 12, 2000Date of Patent: June 4, 2002Assignee: Aclara BioSciences, Inc.Inventors: Kevin Maher, Timothy F. Smith, Torleif Ove Bjornson