Abstract: A risk management system includes one or more computer-readable storage media having instructions stored thereon that, when executed by one or more processors, cause the one or more processors to perform natural language processing to categorize threats to assets and perform correlated risk analyses for threats. The instructions cause the one or more processors generate risk scores for assets using threat data and one or more asset risk profiles reflecting characteristics of the assets, the risk scores weighted based on impact weights of threats. Furthermore, the instructions cause one or more processors to generate a plurality of graphic user interfaces including one or more of a map providing visual representations of the assets, locations of the assets, asset risk scores, and threats to assets, a forecast of asset risk scores, an asset summary, an asset risk profile editor, and a consolidated view of rank ordered assets and threats.

Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

Abstract: The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length.

Abstract: The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

Abstract: A pair of obstetric forceps is described. The forceps comprise a pair of blades for holding the head of a baby and a handle having at least one part by which a user can apply a pulling force on the head of the baby in use. A mechanically operated force indicator is connected to the at least one part of the handle and is operable to provide a visual indication of the amount of pulling force being applied to the head of the baby when a user applies a pulling force on the head of the baby in use. A mechanically operated disabling device is operable to at least partially disable the obstetric forceps when a maximum pulling force has been exceeded. The blades can each have a superior rim and inferior rim wherein the greatest separation between the superior rims is greater than the greatest separation between the inferior rims when the obstetric forceps are in a closed configuration so that the blades adopt the form of an at least partially bowl shape.

Abstract: A pair of obstetric forceps is described. The forceps comprise a pair of blades for holding the head of a baby and a handle having at least one part by which a user can apply a pulling force on the head of the baby in use. A mechanically operated force indicator is connected to the at least one part of the handle and is operable to provide a visual indication of the amount of pulling force being applied to the head of the baby when a user applies a pulling force on the head of the baby in use. A mechanically operated disabling device is operable to at least partially disable the obstetric forceps when a maximum pulling force has been exceeded. The blades can each have a superior rim and inferior rim wherein the greatest separation between the superior rims is greater than the greatest separation between the inferior rims when the obstetric forceps are in a closed configuration so that the blades adopt the form of an at least partially bowl shape.

Abstract: A system includes a computing device that selectively communicates with a self-powered device. The self-powered device has several modes of operation, including a first low-power mode of operation and a second high-power mode of operation. The self-powered device is to communicate with the computing device when the self-powered device is in the second mode of operation. The self-powered device may conserve power by alternating between the first mode of operation and the second mode of operation such that the self-powered device is in the second mode of operation during pre-determined or adaptively-determined time intervals. A duty-cycle of the second mode of operation relative to the first mode of operation may be in accordance with a power budget for the self-powered device.