Patents by Inventor Timothy G. Laske

Timothy G. Laske has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240016603
    Abstract: A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.
    Type: Application
    Filed: September 27, 2023
    Publication date: January 18, 2024
    Inventors: Charles Tabor, Carol E. Eberhardt, Timothy G. Laske, Timothy R. Ryan, Joseph C. Morrow, Tammy Y. Tam, Brian A. Glynn, Anne L. Brody Rubin, Michael J. Tuchek
  • Publication number: 20230414276
    Abstract: A method and a pulsed electric field (PEF) ablation instrument are provided. According to one aspect, a method in a PFA generator includes receiving electrical responses for each of at least one non-therapeutic waveform. The process also includes determining an electric field distribution based at least in part on the received electrical responses. The process further includes selecting a non-therapeutic waveform that produces an electric field distribution that satisfies criteria. The process also includes mapping the selected non-therapeutic waveform to an ablative waveform.
    Type: Application
    Filed: June 21, 2023
    Publication date: December 28, 2023
    Inventors: Timothy G. Laske, Qingguo Zeng, Qing Lou, Mark T. Stewart, Brian T. Howard, Anthony W. Rorvick, Gregory S. Brumfield
  • Publication number: 20230414277
    Abstract: A medical device includes an elongate body, an expandable treatment element, a plurality of flexible shafts, and a plurality of electrodes. The elongate body has a proximal portion and a distal portion opposite the proximal portion. The expandable treatment element is coupled to the elongate body to receive a fluid and, in some examples, is anchored to the plurality of flexible shafts with a plurality of retention elements. In some examples, each flexible shaft of the plurality of flexible shafts has a braided configuration. Each electrode of the plurality of electrodes is attached and electrically coupled to a respective flexible shaft of the plurality of flexible shafts.
    Type: Application
    Filed: June 21, 2023
    Publication date: December 28, 2023
    Inventors: Brian J. Kelly, Gavin J. Kenny, Brian T. Howard, Timothy G. Laske, Andrzej M. Malewicz, Mark T. Stewart
  • Publication number: 20230355301
    Abstract: An example system for use in ablating target tissue includes memory configured to store anatomical and/or physiological information of a patient and processing circuitry communicatively coupled to the memory. The processing circuitry is configured to, based on the anatomical information and/or the physiological information, determine ablation parameters, the ablation parameters including a suggested positioning of at least energy delivery element of at least one catheter and/or an amount of energy to be delivered via the at least one energy delivery element to the target tissue during ablation. The processing circuitry is configured to output, for display, a representation of at least one of a suggested positioning of the at least one energy delivery element during the ablation, a representation of the target tissue, or a representation of the predicted tissue volume that will be ablated after delivery of ablation energy.
    Type: Application
    Filed: April 11, 2023
    Publication date: November 9, 2023
    Inventors: Mary A. Beckman, Heather L. O'Connell, Timothy G. Laske, Mark T. Stewart, Brian T. Howard, Lars M. Mattison, Megan M. Schmidt, Sarah E. Ahlberg
  • Patent number: 11786367
    Abstract: A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: October 17, 2023
    Assignee: MEDTRONIC, INC.
    Inventors: Charles Tabor, Carol E. Eberhardt, Timothy G. Laske, Timothy R. Ryan, Joseph C. Morrow, Tammy Y. Tam, Brian A. Glynn, Anne L. Brody Rubin, Michael J. Tuchek
  • Publication number: 20230321446
    Abstract: An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.
    Type: Application
    Filed: May 16, 2023
    Publication date: October 12, 2023
    Inventors: William E. ROWLAND, Timothy G. LASKE, Qing LOU, Qingguo ZENG
  • Publication number: 20230310072
    Abstract: A method and system for directed pulsed electric field (PEF) ablation are disclosed. In one aspect, an irreversible electroporation (IRE) system includes processing circuitry configured to select a first set of electrodes positioned to produce a first electric field in a first direction in a region of tissue of a patient, and select a second set of electrodes positioned to produce a second electric field in a second direction in the region of tissue. The processing circuitry is configured to transmit a first IRE pulse to the first set of electrodes to cause emission of the first electric field and transmit a second IRE pulse to the second set of electrodes to cause emission of the second electric field. The first IRE pulse and the second IRE pulse are transmitted by the processing circuitry to control an electric field gradient along a path within the region of tissue.
    Type: Application
    Filed: March 27, 2023
    Publication date: October 5, 2023
    Inventors: Mark T. Stewart, Brian T. Howard, Timothy G. Laske
  • Publication number: 20230310871
    Abstract: Implantable medical device including a pulsed-voltage generator and one or more implantable electrical leads. In one example, the implantable medical device supports the defibrillator and ablation modalities characterized by different respective sets of waveform parameters, such as the pulse amplitude and width. In some examples, the implantable medical device also supports a pacing modality. The electrodes used for the different modalities are variously selected from a plurality of electrodes located in distal portions of the implantable electrical leads and on the exterior surface of the implantable device box. An electronic controller of the implantable medical device is wirelessly programmable to appropriately control, e.g., in a patient-specific manner, operations of the pulsed-voltage generator and transitions between different modalities.
    Type: Application
    Filed: April 3, 2023
    Publication date: October 5, 2023
    Inventors: Brian T. Howard, Timothy G. Laske, Alexander J. Hill, Anthony W. Rorvick, Robert C. Kowal
  • Patent number: 11744642
    Abstract: A device, system, and method for optically evaluating and treating or ablating tissue. Specifically, device, system, and method allow for the optical and/or electrical evaluation of tissue at the same location(s) at which ablation or treatment or ablation energy is delivered. This allows for a more accurate evaluation of lesion formation and tissue condition before, during, and/or after a treatment or ablation procedure. In one embodiment, a device for performing a medical procedure includes an elongate body including a proximal portion, a distal portion having a distal end, and a longitudinal axis, and a distal tip electrode at the elongate body distal end, the tip electrode being optically transparent and electrically conductive. The device may also include optical windows in the elongate body aligned with one or more transparent lateral electrodes for optically interrogating tissue and/or for delivering treatment or ablation energy to tissue.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: September 5, 2023
    Assignee: Medtronic, Inc.
    Inventors: Gonzalo Martinez, Timothy G. Laske, Mark T. Stewart
  • Publication number: 20230226361
    Abstract: A computer-implemented method includes accessing electrophysiological data and generating an electroanatomic map for a surface of interest based on the electrophysiological data acquired during or after application of a first intervention to temporarily perturb electrical properties of a region of interest on or within the patient’s heart. The method also includes determining changes in the map or information derived from the map responsive to application of a first intervention. The first intervention can include including applying a non-lethal energy and/or a bioactive agent to induce or inhibit conduction of electrical activity for the region of interest. The method also includes controlling a second intervention to permanently alter the electrical properties of the region of interest based on the determination indicating a desired change in cardiac electrical activity responsive to the first intervention.
    Type: Application
    Filed: November 21, 2022
    Publication date: July 20, 2023
    Inventors: Qing LOU, Qingguo ZENG, TIMOTHY G. LASKE
  • Patent number: 11691018
    Abstract: An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: July 4, 2023
    Assignee: CARDIOINSIGHT TECHNOLOGIES INC.
    Inventors: William Rowland, Timothy G. Laske, Qing Lou, Qingguo Zeng
  • Publication number: 20230190104
    Abstract: A computer-implemented method includes identifying respective heartbeat intervals based on electrophysiological data representative of cardiac electrophysiological signals measured over a time interval. The method includes analyzing the cardiac electrophysiological signals over at least a portion of the time interval. The method also includes generating a map on a surface of interest and/or performing automated signal processing based on the cardiac electrophysiological signals for heartbeat intervals, in which the map is generated and/or the automated signal processing is performed automatically responsive to the analysis of the cardiac electrophysiological signals.
    Type: Application
    Filed: November 10, 2022
    Publication date: June 22, 2023
    Inventors: QINGGUO ZENG, QING LOU, RAHSEAN K. ELLIS, TIMOTHY G. LASKE
  • Publication number: 20230148936
    Abstract: The present disclosure provides a system that includes an arrangement of body surface electrodes on one or more patches adapted to be placed an outer surface of a patient's body. A computing apparatus includes non-transitory memory to store data and instructions executable by a processor thereof. The data includes anatomical geometry data, electrode geometry data and electrical data. The instructions can be programmed to register the anatomical geometry data and the electrode geometry data to provide co-registered geometry data representing the anatomy of the patient and the locations of the body surface electrodes in a common three-dimensional space. Electrophysiological signals can be reconstructed on a cardiac envelope of the heart based on the co-registered geometry data and the electrical data.
    Type: Application
    Filed: September 29, 2022
    Publication date: May 18, 2023
    Inventors: Timothy G. LASKE, Kevin D. GOLLON, Qingguo ZENG, Qing LOU
  • Publication number: 20230138492
    Abstract: A computer-implemented method includes storing location data for at least one invasive electrode that is movable within a patient’s body. The method also includes storing electrophysiological measurement data representing the electrophysiological signals measured at the outer surface of a patient’s body by body surface electrodes and within the patient’s body by the at least one invasive electrode. The method also includes storing geometry data representing anatomy of the patient spatially, and locations of the respective body surface electrodes and the at least one invasive electrode in three-dimensional space. The geometry data for the at least one invasive electrode can vary based on movement of the at least one invasive electrode within the patient’s body. The method also includes reconstructing electrophysiological signals on a surface of interest within the patient’s body based on the electrophysiological measurement data and the geometry data.
    Type: Application
    Filed: September 28, 2022
    Publication date: May 4, 2023
    Inventors: TIMOTHY G. LASKE, QINGGUO ZENG, QING LOU
  • Publication number: 20230107234
    Abstract: A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.
    Type: Application
    Filed: December 8, 2022
    Publication date: April 6, 2023
    Inventors: Thierry Mesana, Timothy G. Laske, Alexander Hill, Timothy Ryan, Allen Tower
  • Publication number: 20230036977
    Abstract: In an example, a signal segment evaluator can be programmed to evaluate a morphology of at least one electrophysiological signal to identify a signal segment of interest. The morphology of the signal segment of interest can be indicative of an electrophysiological event of a patient during a respective time interval. A reconstruction engine can be programmed to reconstruct electrophysiological signals on a surface of interest within a body of the patient based on the electrophysiological signals measured from an outer surface of the patient and geometry data representing an anatomy of the patient. A map generator can be programmed to generate a map representing the reconstructed electrophysiological signals on the surface of interest for the respective time interval of the signal segment of interest. A target generator can be programmed to identify a target site within the patient's body based on the map for the electrophysiological event.
    Type: Application
    Filed: June 14, 2022
    Publication date: February 2, 2023
    Inventors: Qingguo Zeng, Timothy G. Laske, Qing Lou
  • Patent number: 11534295
    Abstract: A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: December 27, 2022
    Assignee: MEDTRONIC, INC.
    Inventors: Thierry Mesana, Timothy G. Laske, Alexander Hill, Timothy Ryan, Allen Tower
  • Publication number: 20220395237
    Abstract: A system coupled to a non-human subject comprising communication circuitry configured to communicatively couple to a medical device coupled to the subject and a remote computing system, the medical device configured to monitor physiological data of the non-human subject and the remote computing system configured to store historical data for the non-human subject; processing circuitry; and a memory comprising instructions that, when executed by the processing circuitry, cause the processing circuitry to: receive the monitored physiological data from the medical device; determine whether the medical device indicates that the monitored physiological data is in satisfaction of at least one condition triggering an upload of at least a portion of the monitored physiological data; and in response to the determination, generate, for communication to the remote computing system, output data comprising the at least a portion of the monitored physiological data.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 15, 2022
    Inventors: Paul A. Iaizzo, Timothy G. Laske, Paul G. Krause, Kevin T O'Brien, Alex E. Kelner
  • Publication number: 20220296295
    Abstract: A medical device including an elongate body having a proximal portion and a distal portion. A plurality of active electrodes is coupled to the distal portion of the elongate body and being configured to electrically couple to a source of pulsed electric field energy. At least one passive electrode is coupled to the elongate body and is not configured to electrically couple to the source of pulsed electric field energy, the at least one passive electrode being configured to passively extend or focus an electric field generated by the plurality of active electrodes.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 22, 2022
    Inventors: Brian T. Howard, Timothy G. Laske, Kenneth C. Gardeski, Gonzalo Martinez, Mark T. Stewart, Lars M. Mattison
  • Publication number: 20220287615
    Abstract: In a described example, a method includes identifying, by a processor, negative deflections of at least one unipolar signal representing cardiac electrical activity on a surface of interest during a respective interval of the at least one signal. The method also includes determining, by a processor, an activation time for a last identified negative deflection in the respective interval. The method also includes detecting, by the processor, an instance of late activation based on comparing the activation time to a temporal threshold.
    Type: Application
    Filed: February 11, 2022
    Publication date: September 15, 2022
    Inventors: QING LOU, TIMOTHY G. LASKE, QINGGUO ZENG, RYAN M. BOKAN, KOONLAWEE NADEMANEE