Abstract: A computer implemented method for identifying a condition is disclosed. The method includes receiving movement data associated with the movement of a subject over a configurable period of time. The method also includes associating the received movement data with a profile of the subject, the profile comprising anatomical data of the subject. The method additionally includes applying a machine learning algorithm to the received movement data and the profile. The method further includes determining, via the machine learning algorithm and based at least in part on the received movement data and the anatomical data of the subject, a likelihood of a mobility disorder.

Abstract: An apparatus includes a first wall and a second wall extending from a planar surface of a substrate to a wall height, and a plurality of electrodes disposed on the first wall and the second wall. The first wall and the second wall can be spaced apart from one another along a first axis on the planar surface. The plurality of electrodes can be configured to generate an electric field to trap an ion at a trapping position located between the first wall and the second wall. A vertical distance between the trapping position and the planar surface of the substrate can be smaller than the wall height.

Abstract: Methods and systems for fabricating 3D electronic devices, such as multielectrode arrays, including metalized, 3D printed structures using integrated 3D printing and photolithography techniques are disclosed. As one embodiment, a multielectrode array comprises a flexible substrate, a plurality of photopatterned electrical traces spaced apart and insulated from one another on the substrate, and a plurality of 3D printed electrodes. Each 3D printed electrode comprises a photopolymer coated in metal and has a 3D structure that extends outward from the substrate, and each 3D printed electrode is electrically connected to a corresponding electrical trace of the plurality of photopatterned electrical traces.

Abstract: A charging system for installation into a block wall includes a docking unit, a cover unit and a charging unit. The docking unit includes a docking unit hollow body with an open front face, and a back plate closing the rear face and an electrical connector positioned within the docking unit hollow body. The cover unit includes a cover unit hollow body for insertion into the docking unit hollow body. The charging unit has a charging unit hollow body for insertion into the docking unit hollow body; and a charger module is located in the charger housing and the charging module includes contacts for connecting to the docking unit electrical connector, and a cable connector for connecting a charging cable.

Abstract: Methods and systems for fabricating 3D electronic devices, such as multielectrode arrays, including metalized, 3D printed structures using integrated 3D printing and photolithography techniques are disclosed. As one embodiment, a multielectrode array comprises a flexible substrate, a plurality of photopatterned electrical traces spaced apart and insulated from one another on the substrate, and a plurality of 3D printed electrodes. Each 3D printed electrode comprises a photopolymer coated in metal and has a 3D structure that extends outward from the substrate, and each 3D printed electrode is electrically connected to a corresponding electrical trace of the plurality of photopatterned electrical traces.

Abstract: Encapsulation devices are provided that comprise an outer wall defining an inner volume, the outer wall comprising a plurality of pores and a plurality of vasculature holes; and a plurality of channels traversing the inner volume, wherein each channel extends from one of the plurality of vasculature holes to another of the plurality of vasculature holes. The device is used for the implantation or delivery of cells, proteins, or other therapeutic molecules. Also provided are methods of treating a disorder in a subject using an encapsulation device described herein. The disclosed encapsulation devices have a porous surface and an internal network of channels passing through the device and connecting with the outside of the device.

Abstract: Implantable nerve cuffs and methods for constructing or manufacturing the same are provided. Also provided is a method for installing a nerve into a nerve passage in the nerve cuff and a system using the nerve cuff. The nerve cuff is configured to retain one or more signal carrying elements such as electrodes proximal to a peripheral nerve in a human or animal subject. The nerve cuff may be constructed using a 3D printing method.

Abstract: A system includes an engine having multiple cylinders and an exhaust manifold. A fuel delivery device and an igniter are disposed in the exhaust manifold. The fuel delivery device injects a fuel into the exhaust manifold. The system also includes an exhaust aftertreatment setup in fluid communication with the exhaust manifold, and a controller in communication with the multiple cylinders, the fuel delivery device and the igniter. The controller is configured to deactivate at least one cylinder to provide air to the exhaust manifold, and control the fuel delivery device to provide the fuel within the exhaust manifold such that the fuel and the air from the at least one deactivated cylinder forms a mixture within the exhaust manifold. The controller is configured to control the igniter to ignite the mixture to generate combustion products within the exhaust manifold for heating the exhaust aftertreatment setup.

Abstract: An exhaust system for an engine having a plurality of combustion chambers includes a housing containing a first array of parallel positioned emission treatment devices and a second array of parallel positioned emission treatment devices axially spaced apart from one another. A first exhaust passageway is in fluid communication with the combustion chambers and contains the first array of emission treatment devices. A second and separate exhaust passageway is in fluid communication with the combustion chambers and contains the second array of emission treatment devices. A first valve restricts the exhaust flow through the first exhaust passageway. A second valve restricts the exhaust flow through the second exhaust passageway.

Abstract: The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

Abstract: An exhaust system for an engine having a plurality of combustion chambers includes a housing containing a first array of parallel positioned emission treatment devices and a second array of parallel positioned emission treatment devices axially spaced apart from one another. A first exhaust passageway is in fluid communication with the combustion chambers and contains the first array of emission treatment devices. A second and separate exhaust passageway is in fluid communication with the combustion chambers and contains the second array of emission treatment devices. A first valve restricts the exhaust flow through the first exhaust passageway. A second valve restricts the exhaust flow through the second exhaust passageway.

Abstract: A vehicle exhaust system for an engine having a plurality of combustion chambers includes a first emission treatment device, a second emission treatment device and a housing defining a first exhaust passageway in fluid communication with the combustion chambers and containing the first emission treatment device. A second parallel exhaust passageway is in fluid communication with the combustion chambers and contains the second emission treatment device. The first and second passageways share a common wall having a serpentine shape such that the cross-sectional area of the passageways varies along a direction of exhaust flow. The first emission treatment device is positioned at a location of increased cross-sectional area in the first passageway and the second emission treatment device is positioned at an axially offset location of increased cross-sectional area in the second passageway.

Abstract: A diesel exhaust gas aftertreatment system (10) is provided to treat the exhaust (12) from a diesel combustion process (14), such as a diesel compression engine (16). The system (10) includes a burner (18) that selectively supplies the exhaust (12) at an elevated temperature to the rest of the system (10), a diesel particulate filter (20) connected downstream from the burner (18) to receive the exhaust (12) therefrom, and a NOx reducing device (22) connected downstream from the filter (20) to receive the exhaust therefrom.

Abstract: The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

Abstract: The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

Abstract: An apparatus for head mounting gear for hands free operation includes a headband and adjustable mounting structure wherein gear such as binoculars and range finders may be selectively mounted, and such gear once mounted may be conveniently raised to a storage position or placed in a use position. The structure includes a quick release mechanism which enables quick and easy interchange between various gear. The headband is preferably comprised of an encircling band and a band that goes over the top of the head. The mounting support structure has adjustments for length from the eyes and height. It is further adjustable into multiple use positions and vertical angle line of sight adjustment.

Abstract: Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant genetic toggle switches which contain a first constitutive promoter-regulatory gene operon and a second constitutive promoter-regulatory gene operon. Expression of the regulatory gene from the first operon inhibits expression from the promoter in the second operon, and expression of the regulatory gene from the second operon inhibits expression from the promoter in the first operon. By use of the toggle switch and various switching agents it is possible to reversibly switch the expression of a gene of interest between a stable “on” state and stable “off” state or vice versa via transient exposure to a switching agent.

Abstract: Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant adjustable-threshold switches which contain a first inducible promoter-regulatory gene operon and a second constitutive promoter-regulatory gene operon. A threshold amount of activating agent is required to switch the inducible promoter “on” and the constitutive promoter “off”. An adjustable-threshold switch is useful to reversibly switch the expression of a gene of interest between a stable “on” state and stable “off” state in response to an activating agent at or above a threshold concentration.

Abstract: Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant multi-state genetic oscillators containing an adjustable-threshold genetic switch that is periodically activated by an oscillating amount of an activator agent. The activating agent is a gene product expressed from a promoter regulated by the adjustable-threshold switch and thus forms a feedback loop that causes periodic switching of the adjustable-threshold switch between an “on” state and an “off” state. Multi-state genetic oscillators are useful to express one or more genes of interest in a periodic manner without requiring a periodic application of an external activating agent.

Abstract: Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant genetic toggle switches which contain a first constitutive promoter-regulatory gene operon and a second constitutive promoter-regulatory gene operon. Expression of the regulatory gene from the first operon inhibits expression from the promoter in the second operon, and expression of the regulatory gene from the second operon inhibits expression from the promoter in the first operon. By use of the toggle switch and various switching agents it is possible to reversibly switch the expression of a gene of interest between a stable “on” state and stable “off” state or vice versa via transient exposure to a switching agent.