Abstract: A road overlay product for protecting a repaired road portion including repaired potholes and utility cuts. A pothole or utility cut is preliminarily repaired with asphalt fill and compacted per current standard practice. Thereafter, the overlay is placed upon the compacted top surface of the asphalt fill, overlapping onto the adjacent road surface and compressed. The overlay forms a water proof seal preventing water from seeping into the repaired area. The overlay also resists crack propagation and minimizes the potential of asphalt chipping and the breaking down of the asphalt fill and surrounding roadway.

Abstract: The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 11, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 11, or at positions corresponding to positions 11 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.

Abstract: A road overlay product for protecting a repaired road portion including repaired potholes and utility cuts. A pothole or utility cut is preliminarily repaired with asphalt fill and compacted per current standard practice. Thereafter, the overlay is placed upon the compacted top surface of the asphalt fill, overlapping onto the adjacent road surface and compressed. The overlay forms a water proof seal preventing water from seeping into the repaired area. The overlay also resists crack propagation and minimizes the potential of asphalt chipping and the breaking down of the asphalt fill and surrounding roadway.

Abstract: A road patch for repair of potholes is disclosed. A pothole is preliminarily repaired with asphalt fill and compacted per current standard practice. Thereafter, a road patch is placed upon the compacted top surface of the asphalt fill, overlapping onto the adjacent road surface and compressed. The road patch forms a water proof seal over the surface area of the patch preventing water from seeping into the repaired pothole. The patch also resists crack propagation and minimizes the potential of asphalt chipping and the breaking down of the asphalt fill.

Abstract: A road patch for repair of potholes is disclosed. A pothole is preliminarily repaired with asphalt fill and compacted per current standard practice. Thereafter, a road patch is placed upon the compacted top surface of the asphalt fill, overlapping onto the adjacent road surface and compressed. The road patch forms a water proof seal over the surface area of the patch preventing water from seeping into the repaired pothole. The patch also resists crack propagation and minimizes the potential of asphalt chipping and the breaking down of the asphalt fill.

Abstract: The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 1 1, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 1 1, or at positions corresponding to positions 1 1 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.

Abstract: The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

Abstract: This invention describes novel methods for the identification of compounds useful as inhibitors of enzymes. The methods involve obtaining a target gene-complemented microorganism which is dependent on the expression of the target gene for survival in test conditions. By measuring the viability of the complemented microorganism after exposure to a compound, compounds that inhibit growth in test conditions are identified. These compounds that inhibit growth are further tested in conditions where the expression of the target gene is not required for growth in order to identify compounds that specifically inhibit the target gene but do not effect the viability of the host.