Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A method of separating plastic material from battery materials can include: a) receiving battery materials in an immersion comminuting apparatus; b) by carrying out at least a first size reduction of the battery materials under immersion to create a primary-reduced metal material, primary-reduced plastic material and liberating a first amount of a black mass material; c) extracting at least a primary plastics slurry from the primary comminuting apparatus, wherein the primary plastics slurry comprises a mixture of the primary-reduced plastic material, a portion of the primary-reduced metal material and a portion of the black mass material liberated by the immersion comminuting apparatus; and d) carrying out a further, second size reduction of the plastic slurry using a non-immersion comminuting apparatus that is downstream from the immersion comminuting apparatus.

Abstract: In some illustrative embodiments, a system suitable for treating a tissue site may include a dressing, a low-profile conduit, a conduit interface, and a reduced-pressure source. The dressing may be adapted for positioning at the tissue site. The low-profile conduit may be adapted for fluidly coupling to the dressing. The low-profile conduit may include a manifold and a sealing member encapsulating the manifold. The conduit interface may be adapted for fluidly coupling to the low-profile conduit. The conduit interface may be in fluid communication with the dressing through the low-profile conduit. The reduced-pressure source may be adapted for fluid communication with the conduit interface. Other systems, devices, and methods are disclosed.

Abstract: A system comprising a computer-readable storage medium storing at least one program, and a computer-implemented method for enhancing and personalizing an interactive marketplace. The systems and methods provided herein may allow a user to receive search results that are tailored to the user's personal preferences based on social and purchasing information known about the user. In addition, the systems and methods provided herein may provide shipping updates to a buyer that include a personalized message based on location information provided by the package being shipped. In addition, the systems and methods provided herein allow merchants to provide incentives and rewards for shoppers by participating in interactive shopping games.

Abstract: Connected computing enables the use of highly diverse environments that support operating frameworks for contemporary civilization. But computing productivity and trustworthiness are undermined by such environments' largely inchoate organization. These environments and their identity infrastructures are fragmented, and unnecessarily unreliable, insecure, and insufficiently informative due to current computing entity (e.g., resource) identification infrastructure design, which lacks root identification reliability. Such reliability is enabled herein by a fundamentally accurate and authenticity ensuring, near-existential or existential quality, biometrically and liveness based, portable identification and provenance infrastructure. Such an infrastructure provides ubiquitously available identification information that can be used universally for identification processes.

Abstract: The present disclosure is directed methods and apparatus of a V-Bank filtration system capable of maintaining desired air flow rates while effectively filtering the air. These methods and apparatus charge particles and then capture those particles in a filter medium. Once captured in the filter medium, micro-organisms are exposed to high energy electric fields that may degrade and ultimately destroy the captured micro-organisms. Electric fields generated within portions of the V-Bank filter apparatus may also be contained within the portions of the filter apparatus based on exterior parts of these portions being grounded at Earth ground potential. Magnetic fields (or electro-magnetic fields) associated with the generated electric fields may also be contained within the portions of the apparatus based on the exterior parts of these portions being grounded.

Abstract: A method of manufacturing an electrical conductor assembly includes attaching a substrate and at least one electrical conductor to a cable assembly machine, tensioning the substrate, and holding the substrate stationary while wrapping the at least one electrical conductor around the substrate. The at least one electrical conductor is wrapped around the substrate independent of the tension on the substrate.

Abstract: A method and apparatus for reducing jitter in a phase-locked loop (PLL). Clock signals provided to the PLL are resampled into the voltage domain of the VCO in the PLL rather than being merely level shifted into that voltage domain or input directly from digital domain clock dividers as in the prior art. The resampling is done with flip-flops in the analog domain using a faster synchronous clock in each case, and results in cleaner clock edges being presented to the PLL than those provided by the digital circuitry alone. A divided input clock signal is resampled using the undivided input clock, while a divided feedback clock signal is resampled using the feedback clock signal itself, i.e., the output of the VCO in the PLL. This removes jitter caused by the processing of clock signals in the digital voltage domain and thus reduces the jitter in the output signal.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.

Abstract: A user equipment (UE) can connect to an evolved universal terrestrial radio access network (E-UTRAN) new radio (NR) dual-connectivity (EN-DC) network using both a Long Term Evolution (LTE) anchor link and a 5G NR non-anchor link. The UE shares RF chain components (e.g., antennas) between the LTE and NR links. The UE uses various techniques for controlling or modifying NR sounding reference signal (SRS) transmissions and/or LTE operations to avoid interruption on LTE operations due to NR SRS transmissions.

Abstract: A method of separating plastic material from battery materials can include: a) receiving battery materials in an immersion comminuting apparatus; b) by carrying out at least a first size reduction of the battery materials under immersion to create a primary-reduced metal material, primary-reduced plastic material and liberating a first amount of a black mass material; c) extracting at least a primary plastics slurry from the primary comminuting apparatus, wherein the primary plastics slurry comprises a mixture of the primary-reduced plastic material, a portion of the primary-reduced metal material and a portion of the black mass material liberated by the immersion comminuting apparatus; and d) carrying out a further, second size reduction of the plastic slurry using a non-immersion comminuting apparatus that is downstream from the immersion comminuting apparatus.

Abstract: A pharmaceutical container may include a cylindrical hollow container body (100) defining a hollow chamber (111) to receive a pharmaceutical liquid, the container body (100) including a portion on a sidewall (121) of the container body (100), wherein the portion has a longitudinal extension along the longitudinal axis of the container body (100) and a circumferential extension along the circumference of the container body (100), thereby forming a window (122) through the sidewall (121) of the container body (100) into the hollow chamber (111), the window (122) comprising two long edges (124) and two short edges (125), and a Near Field Communication (NFC) antenna (110) arranged on the outer surface (120) of the sidewall (121) of the container, the antenna (110) including one or a plurality of nested antenna windings (150), each of them surrounding an interior periphery (140) including a substantially longitudinal portion (141) arranged along the two long edges (124) of the window (122), and a substantially cir

Abstract: A multi-layer, lithium anode assembly for use in a lithium-based battery can include a substrate region having a current collector comprising a continuous copper foil that is between 4 and 10 microns thick and has a lithium compatible support surface. A lithium hosting region may overlie the support surface and may include a lithium material film deposited directly onto the support surface via thermal evaporation and having a thickness that is between 1 microns and 10 microns. A cover region may be located outboard of the lithium hosting region and may have a cover film comprising a lithiophilic material deposited directly onto an exposed surface of the lithium material film via physical vapour deposition, thereby enhancing mobility of lithium ions travelling through the cover region and between an electrolyte and the lithium hosting region so that dendrite formation is inhibited when lithium is deposited in the lithium hosting.

Abstract: A flotation separator apparatus can include a tank for receiving an incoming feed stream comprising plastic material and metal material liberated from battery materials. A separator liquid can be within the tank and at least a first submersion agitator may be located downstream from an inlet and may have at least a first engagement member that is movable and configured to urge the engaged metal and plastic materials downwardly to submerge them in the separator liquid thereby dislodging at least a first portion of metal material from the plastic material and allowing the dislodged first portion of the metal material to precipitate toward the lower end of the tank.

Abstract: A vibratory flowmeter (5) for meter verification is provided, including meter electronics (20) coupled to the first and second pickoff sensors (170L, 170R) and coupled to a driver (180), with the meter electronics (20) configured to: vibrate the flowmeter assembly (10) in a single mode using the driver (180), determine a single mode current (230) of the driver (180) and determine first and second response voltages (231) generated by the first and second pickoff sensors (170L, 170R), respectively, compute frequency response functions for the determined first and second response voltages (231) from the determined single mode current (230), fit the generated frequency response functions to a pole-residue model, and verify proper operation of the vibratory flowmeter (5) using the meter stiffness value (216), residual flexibility (218), and the meter mass (240) in embodiments.

Abstract: Implementations described and claimed herein provide an underwater vehicle includes a vehicle body having a frame enclosed by a fairing. The vehicle body extends between a proximal end and a distal end and defining an interior. A nose is disposed at the proximal end of the vehicle body. The nose has a tow system configured to move between a tow position and a stow position. A propulsion system is disposed at the distal end of the vehicle body. The propulsion system includes a plurality of control fins and a thruster. A power distribution system is housed in the interior of the vehicle body. The power distribution system includes a first power system housed in a first pressure vessel and a second power system housed in a second pressure vessel. The first pressure vessel is isolated from the second pressure vessel.

Abstract: A method of precipitating copper sulphide from an incoming feed stream comprising copper liberated from within battery materials can includes the steps of: a) receiving an incoming feed stream comprising copper entrained in a carrier liquid in a precipitation apparatus; b) introducing a sulphide reductant to the feed stream to precipitate copper sulphide solids out of the feed stream during a precipitation residence time that is less than 24 hours to produce a copper sulphide slurry; and processing the copper sulphide slurry to separate the precipitated copper sulphide solids and provide a copper-depleted stream.

Abstract: A laser system provides a system output signal and a monitor signal with a predetermined phase and/or frequency relationship to the system output signal. The monitor signal is combined with a reference frequency to yield an optical beat-note. A telecom optical transceiver (e.g., an SFP or an SFP+ module) is used to convert the optical beat-note to an analog electrical beat-note. The transceiver can extract received-power information from the analog electrical beat-note and digitize the analog electrical beat-note to yield a digital electrical beat-note. The digital electrical beat-note can be used to stabilize the laser and the system output signal by phase or offset locking.

Abstract: A method of controlling deposition of material from at least one plasma transferred wire arc (PTWA) torch within at least one bore includes: directing a fluid through a duct; and directing the fluid through a number of cannons N disposed adjacent and downstream from the duct. The fluid is directed through the duct and N cannons and past the PTWA torch while the PTWA torch is spraying downstream from N?1 cannons.

Abstract: A system includes an array of connected disinfecting filter assembly modules arranged in a plane to filter air that passes through the array as the air flows along an airflow pathway through the array. Each module includes a housing that defines a first slot and a second slot, and a power control unit. A pre-filter can be slid in its operating position along the first slot of the housing, and an electrically enhanced filter can be slid in its operating position along the second slot. The electrically enhanced filter includes a high voltage wire and a ground grid to create an electric field the high voltage wire and the ground grid and an electrical contact pad that electrically connects the power control unit to the high voltage wire when the electrically enhanced filter is located in its operating position in the second slot of the housing.